Results 71 to 80 of about 1,434,331 (312)

Multifunctional Gold Nanocluster‐Based PROTAC System for Targeted Degradation of Phosphorylated Tau and Modulation of Neuroinflammation in Alzheimer's Disease

Advanced Functional Materials, EarlyView.
We present a novel proteolysis‐targeting chimera (PROTAC) system conjugated to lipoic acid gold nanoclusters (PLANC), designed to degrade pTau, regulate inflammatory signaling, and effectively traverse the blood‐brain barrier (BBB). PLANC degraded pTau at various phosphorylation sites, with mechanistic studies confirming proteasome‐mediated degradation
Sarah Nevins, Callan D. McLoughlin, Wan‐Kyu Ko, Hye Kyu Choi, Brandon Conklin, Joshua B. Stein, Yannan Hou, Hongwon Kim, Rohan Khulbe, Ki‐Bum Lee   +9 more
wiley   +1 more source

Dynamic Nuclear Polarization NMR Spectroscopy: Revealing Multiple Conformations in Lipid-Anchored Peptide Vaccines

, 2013
Sensitivity is the key: Dynamic nuclear polarization NMR spectroscopy provides structural information on liposomal vaccines targeting Alzheimer's disease. DMPC/DMPG/Cholesterol mainly stabilizes extended structures of the lipid-anchored peptide, while in
Koers, E.J., López-Deber, M.P., Muhs, A., Reis, P., Nand, D., Sub NMR Spectroscopy, Granet, A., NMR Spectroscopy, Baldus, M., Mlaki Ndao, D., Weingarth, M.H., Pfeifer, A., Hickman, D.T.   +12 more
core   +1 more source

Anion‐Exchange‐Enabled Hydrogel Electrolytes With High Zn2+ Transference for Dendrite‐Free Flexible Zinc‐Ion Batteries

Advanced Functional Materials, EarlyView.
A high‐Zn2+‐transference hydrogel electrolyte of ex‐PDADAM is developed via anion exchange at quaternary ammonium sites, achieving high Zn2+ transference number (0.86), ionic conductivity (8.10 mS cm−1), and toughness (51.25 MJ m−3). Symmetric cells are operated stably for over 2000 h, while flexible pouch cells retain 90.9% capacity after 300 cycles ...
Jung Woo Hong, Yeon Su Kim, Zuyang Hu, Hyungyu Cho, Gun Jang, Minjun Hwang, Hye Rin Park, Jun Su Kim, Ho Seok Park   +8 more
wiley   +1 more source

Diagnostic performance of a multi-shell DTI protocol and its subsets with B-matrix spatial distribution correction in differentiating early multiple sclerosis patients from healthy controls

Frontiers in Neurology
IntroductionThis study investigates whether a multi-shell diffusion tensor imaging (DTI) protocol and its subsets can reliably distinguish healthy controls (HC) from patients with multiple sclerosis (MS) presenting with low Expanded Disability Status ...
Artur Tadeusz Krzyzak, Artur Tadeusz Krzyzak, Julia Lasek, Julia Lasek, Agnieszka Slowik   +4 more
doaj   +1 more source

Synthesis and physical-chemical properties of 8-aminoderivatives of 7-m-bromobenzyl-3-methylxanthine

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2020
The current stage of scientific and technological progress in pharmaceutical science is associated with the development of the targeted synthesis of biologically active compounds and the creation of new highly effective and low-toxic drugs on their basis
M. I. Romanenko , D. H. Ivanchenko, K. V. Aleksandrova, O. B. Makoid   +3 more
doaj   +1 more source

Solid-state NMR on complex biomolecules: Methods and applications [PDF]

, 2018
Solid-state NMR (ssNMR) can provide structural information at the most detailed level and, at the same time, is applicable in highly heterogeneous and complex molecular environments, largely irrespective of solubility or crystallinity.
Baldus, Marc, NMR Spectroscopy, Sub NMR Spectroscopy, Weingarth, Markus, Mance, Deni, Webb, Graham A., Marc Baldus, Markus Weingarth, Deni Mance   +8 more
core   +1 more source

Surprising Water Slipping Performance on Highly Hydrophilic PEG‐Derived Monolayer‐Covered Surfaces: Preparation, Mechanism, and Application

Advanced Functional Materials, EarlyView.
Highly hydrophilic surfaces (water contact angle, ≈17.7°) exhibiting surprising water slipping performance (sliding angle, ≈7.3°) are successfully prepared via simple chemisorption of polyethylene glycol (PEG) organosilane and subsequent alkali‐treatment.
Hyeonjin Kim, Kouki Akaike, Jerred Wassgren, Hiroshi Kakiuchida, Masahisa Okada, Atsushi Hozumi   +5 more
wiley   +1 more source

Selective Membrane Transport Systems studied by Solid-State NMR Spectroscopy

, 2009
Membranes border cells from their environment. Thus, they belong to the basic prerequisites for life as we know it. Within cells, membranes are used to establish compartments dedicated to specific tasks such as providing local proximity of components ...
Ader, C., NMR Spectroscopy, NMR-spectroscopie, Sub NMR Spectroscopy   +3 more
core  

An Efficient Labelling Approach to Harness Backbone and Side-Chain Protons in 1H-Detected Solid-State NMR Spectroscopy [PDF]

, 2015
1H-detection can greatly improve spectral sensitivity in biological solid-state NMR (ssNMR), thus allowing the study of larger and more complex proteins.
Sinnige, Tessa, Daniëls, Mark, Baldus, Marc, NMR Spectroscopy, Sub NMR Spectroscopy, Narasimhan, Siddarth, Weingarth, Markus, Mance, Deni, Kaplan, M., Houben, Klaartje   +9 more
core   +1 more source

Coupling Anodic Activity and Stability at Ni‐Based Non‐Oxide Catalysts via Coordinating Alcohol Oxidation and Oxygen Evolution

Advanced Functional Materials, EarlyView.
A cooperative and competitive interrelationship between alcohol oxidation (AOR) and water oxidation (OER) was observed on a typical anode catalyst of Ni2P. In situ Raman spectroscopy and electrochemical analyses revealed a specific complementary mechanism between them, in which OER and AOR critically contribute to the activity and stability of anodic ...
Yong Yan, Xinyu Liu, Yuguo Zhao, Hanwen Jian, Huan Zhou, Riyi Zhang, Dong Wang, Peter Schaaf, Lihua Wang, Guangsheng Guo, Xiayan Wang   +10 more
wiley   +1 more source