Results 51 to 60 of about 4,332,931 (306)
Molecular action of NZ2114, a superior plectasin derivative
npj Antimicrobials and ResistanceNZ2114 is a triple-mutant of the natural peptide antibiotic plectasin that targets the peptidoglycan precursor molecule Lipid II using a supramolecular action, involving assembly of plectasin-Lipid II complexes in a large oligomeric structure, that is ...
Maik G. N. Derks +11 more
doaj +1 more source
Early Stage Diagnosis of Oral Cancer Using 1H NMR–Based Metabolomics
Neoplasia: An International Journal for Oncology Research, 2009 Oral cancer is the eighth most common cancer worldwide and represents a significant disease burden. If detected at an early stage, survival from oral cancer is better than 90% at 5 years, whereas late stage disease survival is only 30%.
Stefano Tiziani +2 more
doaj +1 more source
Nature Communications, 2020 Microtubule (MT) organization is regulated by many microtubule-associated proteins (MAPs) that contain intrinsically disordered regions. Here authors produce [13C, 15N] labeled, functional microtubules from human cells for solid-state NMR which allows ...
Yanzhang Luo +8 more
doaj +1 more source
Nuclear Magnetic Resonance (NMR) Spectroscopy in Food Science: A Comprehensive Review.
Comprehensive Reviews in Food Science and Food Safety, 2018 Nuclear magnetic resonance (NMR) spectroscopy is a robust method, which can rapidly analyze mixtures at the molecular level without requiring separation and/or purification steps, making it ideal for applications in food science.
E. Hatzakis
semanticscholar +1 more source
Detection of Metabolites by Proton Ex Vivo NMR, in Vivo MR Spectroscopy Peaks and Tissue Content Analysis: Biochemical-Magnetic Resonance Correlation: Preliminary Results [PDF]
, 2009 *Aim*: Metabolite concentrations by in vivo magnetic resonance spectroscopy and ex vivo NMR spectroscopy were compared with excised normal human tissue relaxation times and tissue homogenate contents. *Hypothesis*: Biochemical analysis
Madan Rehani +2 more
core
FEBS Letters, EarlyView.Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley +1 more source
How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome
FEBS Letters, EarlyView.In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini +3 more
wiley +1 more source
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Nuclear magnetic resonance spectroscopy and computational methods for the characterization of materials in solution and the solid state [PDF]
, 2010 Nuclear Magnetic Resonance (NMR) and computational methods increasingly play a predominant and indispensable role in modern chemical research. The insights into the local nuclear environment that NMR can provide is unique information which allows the ...
Carnevale, Diego
core +2 more sources
31P NMR Studies of Phospholipids [PDF]
, 2015 31P nuclear magnetic resonance (NMR) can provide information on the composition of phospholipid (PL) membranes, lipid headgroup orientation relative to the bilayers normal, and the phase state of PL systems.
Munavirov, Bulat, +5 more
core +2 more sources