Results 181 to 190 of about 146,160 (249)

Unraveling the Crystal Structures of Picolinic Acid Derivatives: Synthesis, Packing, Interactions, and Conformational Flexibility

open access: yesChemistryOpen, EarlyView.
Subtle changes transform crystal structures: synthesis, interactions, and flexibility of novel picolinic acid derivatives with promising biomedical applications, detailed through X‐ray diffraction and conformational modeling. Picolinic acid and its derivatives are widely used as pendant arms in ligands for metal ion complexation, with possible ...
Sara Camorali   +3 more
wiley   +1 more source

Harnessing Molecular and Bioactivity Network Analysis to Prioritize Antibacterial Compound Isolation From Ant‐Associated Fungi

open access: yesPhytochemical Analysis, EarlyView.
ABSTRACT Introduction Antimicrobial resistance is a global public health problem that requires the development of new bioactive compounds. In this context, metabolomic analyses can expedite the research of fungal metabolites as a valuable resource. Objectives To investigate the metabolic profiles and isolate antibacterial compounds from micromycetes ...
Ángel S. Aguilar‐Colorado   +2 more
wiley   +1 more source

Targeted Isolation of Coumarins From Sideritis Species Based on Antiviral Screening and Untargeted Metabolomics

open access: yesPhytochemical Analysis, EarlyView.
ABSTRACT Introduction The SARS‐CoV‐2 pandemic has revealed a deficiency in antiviral agents. Plants, traditionally used for respiratory infections, are valuable sources of antiviral compounds. Such a plant is the Sideritis L. taxa (mountain tea), traditionally used against cold and cough.
Ekaterina‐Michaela Tomou   +5 more
wiley   +1 more source

Metabolite Screening From Pinus pinea Needles Reveals (+)‐Isocupressic Acid as a Key Phytotoxin for Weed Management

open access: yesPhytochemical Analysis, EarlyView.
This study explores the phytotoxicity of Pinus pinea needle extracts and metabolites to evaluate their potential for controlling dicotyledonous weeds. A strategy based on GC–MS, NMR, and optical methods revealed an array of aromatic compounds which are of crucial interest for phytochemical research. Hence, a bio‐guided purification led to the isolation
Hajer Hlaili   +11 more
wiley   +1 more source

PyINETA: Open-Source Platform for INADEQUATE-JRES Integration in NMR Metabolomics. [PDF]

open access: yesAnal Chem
Taujale R   +5 more
europepmc   +1 more source

The Actin‐Binding Prolyl‐Isomerase Par17 Sustains Its Substrate Selectivity by Interdomain Allostery

open access: yesProteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT The human peptidyl‐prolyl‐cis/trans isomerases (PPIases), Parvulin 14 and Parvulin 17, accelerate the cis/trans isomerization of Xaa‐Pro moieties within protein sequences. By modulating the respective binding interfaces of their target proteins, they play a crucial role in determining the fate of their substrates within the cell. Although both
Anna Sternberg   +9 more
wiley   +1 more source

Development of an Automated Workflow for Screening the Assembly and Host-Guest Behavior of Metal-Organic Cages Towards Accelerated Discovery. [PDF]

open access: yesAngew Chem Int Ed Engl
Basford AR   +8 more
europepmc   +1 more source

Structural and Functional Characterization of the 28 kDa Structured Core of BmSA1, the Major Surface Antigen of Babesia Microti

open access: yesProteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Babesiosis is a tick‐borne disease that poses a significant threat to animal health worldwide. In addition, climate change and the risk of human‐to‐human transmission through blood transfusion have made babesiosis an emerging disease in humans.
Assia Mouhand   +4 more
wiley   +1 more source

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