Results 231 to 240 of about 1,583,705 (314)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Case Report: donor cell-derived leukemia after allogeneic stem cell transplantation for metastatic renal cell carcinoma. [PDF]

Front Immunol
Monaco F, Tran DT, Sandmaier BM, Tykodi SS.   +3 more
europepmc   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Long-term outcomes of lung transplantation in the elderly: an analysis using the UNOS database. [PDF]

J Thorac Dis
Shtraichman O, Meyer JS, Zur A, Leor G, Aravot D, Peysakhovich Y, Shostak Y, Kramer MR, Barac YD.   +8 more
europepmc   +1 more source

Optimising transfusion practices in preterm neonates using gestational age and birth weight-based prediction model: a retrospective cohort study from India. [PDF]

BMJ Paediatr Open
Krishnakumar M, Ajith A, Gutjahr G, Biju S, Shenoy V, A D, Bendapudi P.   +6 more
europepmc   +1 more source

From laparoscopy to robotics in living donor hepatectomy: a systematic review and meta-analysis of comparative outcomes. [PDF]

J Robot Surg
Al Sayed M, Albashier M, Altabbaa H, Omar Saleh A, Hadhoud AM, Hussein MA, Aljarrah AY, Abdelrazek MM, Bakhiet M.   +8 more
europepmc   +1 more source

Association of PIRCHE scores and allograft injury in kidney transplant recipients. [PDF]

Front Immunol
Molnar MZ, Holdaway KJ, Raghavan D, Marineci S, Oygen S, Toth F, Fornadi K.   +6 more
europepmc   +1 more source

Association Between Sex and Kidney Transplant Referral, Living Donor Contacts, Waitlisting and Kidney Transplant: A Population-Based Cohort Study. [PDF]

Can J Kidney Health Dis
Naylor KL, Zitoun N, Smith G, Romain J, Garg AX, Roberston-Hogg K, Knoll G, Kim SJ, Yoahnna S, Weir M.   +9 more
europepmc   +1 more source