Results 61 to 70 of about 22,944,294 (221)
Artificial Intelligence‐Guided Phenotypic Drug Repurposing Against Streptococcus pneumoniae
Advanced Science, EarlyView.Integrated artificial intelligence (AI) ensembles identify highly potent repurposed drugs against Streptococcus pneumoniae. Prospective virtual screening of 6747 drugs uncovers nine active candidates, including thiostrepton. This drug exhibits low picomolar potency and bypasses established resistance in multidrug‐resistant strains, demonstrating an ...
Joshua S. Fitch +6 more
wiley +1 more source
Medical Microbiology in Practice: past and current situations in Iran
Iranian Journal of Microbiology, 2015 No ...
Bahram Fatolahzadeh
doaj
Advanced Science, EarlyView.PTEN knockdown activates AKT phosphorylation, promoting Nrf2 nuclear translocation and STAT3 activation, which upregulates GPX4 and antioxidant enzymes HO‐1, SOD1, SOD2, and NQO1. These coordinated changes reduce lipid peroxidation and ROS, inhibit ferroptosis, and ultimately ameliorate cognitive impairment in APP/PS1 transgenic mice, highlighting a ...
Da‐Wei Wang +5 more
wiley +1 more source
Advanced Science, EarlyView.Low latency carbon budget estimates for July 2024–June 2025 combine atmospheric CO2 growth rates, fossil emissions, ocean uptake, DGVM land fluxes, and OCO‐2 inversions. The budget shows that late‐2024 land carbon losses dominate the annual anomaly, while early‐2025 recovery differs between bottom‐up models and top‐down inversions, especially in ...
Piyu Ke +32 more
wiley +1 more source
Procedimientos para la extracción de palabras clave de páginas web basados en criterios de posicionamiento en buscadores / Procedures for extracting keywords from web pages, based on search engine optimization [PDF]
, 2010 We present a research project whose main objective is the development of a tool that facilitates the assignment of keywords to web documents. We synthesize the main characteristics and features of the tool we are constructing and analyze its theoretical ...
Pedraza-Jimenez, Rafael +3 more
core +1 more source
Iranian Journal of Public Health, 2017 A Case Study of the Relationship between Basic Psychological Needs and General Health among Old ...
Azam BAZOOBAND +2 more
doaj
Spatiotemporal Multi‐Omic Mapping Reveals Liver‐Muscle Metabolic Crosstalk in Cancer Cachexia
Advanced Science, EarlyView.The interactive CCAtlas platform delineates cross‐species, spatiotemporal, and sex‐specific molecular dynamics and metabolic rewiring across organs during cancer cachexia. Hepatic Gamt downregulation curtails hepatic creatine synthesis to trigger systemic creatine insufficiency and consequent skeletal muscle atrophy in LLC tumour‐bearing mice ...
Zihan Tian +12 more
wiley +1 more source
Treatment of Cutaneous Leishmaniasis in Persian Medicine
Iranian Journal of Public Health, 2017 Treatment of Cutaneous Leishmaniasis in Persian ...
Omid MOZAFARI +3 more
doaj
New keywords a revised vocabulary of culture and society
, 2005 "What does culture mean to us today? In New Keywords, three luminaries in the field of cultural studies have assembled a volume showcasing 142 signed entries that capture the practices, institutions, and debates of contemporary society.
Bennett, Tony 1947-
core
Advanced Science, EarlyView.Non‐canonical amino acids (ncAAs) enhance peptide therapeutics but remain difficult to model computationally. SinCAA, a similarity‐enhanced pretraining framework, jointly optimizes contrastive learning guided by a novel conformational similarity metric with masked node reconstruction, capturing both functional relationships and chemical identity of ...
Chencheng Xu +8 more
wiley +1 more source