Results 91 to 100 of about 1,885,648 (256)

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

Risks to human and animal health related to the presence of deoxynivalenol and its acetylated and modified forms in food and feed [PDF]

, 2017
Peer reviewedPublisher ...
EFSA Panel on Contaminants in the Food Chain (CONTAM)
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

In vitro and in vivo toxicological evaluation of 6′-Sialyllactose sodium salt produced by a novel method

Toxicology Reports
6′-Sialyllactose (6′-SL) sodium salt is the sodium salt of a naturally occurring trisaccharide found in dairy products and human milk. 6′-SL sodium salt formulations produced by different methods have been the subject of other safety studies and are ...
Rit B. Gurung, Laurie C. Dolan, Benjamin G. Arceneaux, Hiroe Go, Eun Jung Park   +4 more
doaj   +1 more source

Aspirin for prophylactic use in the primary prevention of cardiovascular disease and cancer : a systematic review and overview of reviews [PDF]

, 2013
Background: Prophylactic aspirin has been considered to be beneficial in reducing the risks of heart disease and cancer. However, potential benefits must be balanced against the possible harm from side effects, such as bleeding and gastrointestinal (GI ...
Clarke, Aileen, Connock, M., Freeman, Karoline, Grove, Amy L., Gurung, B., Gurung, T., Johnson, Samantha Ann, Kandala, Ngianga-Bakwin, Morrow, S., Sutcliffe, P. (Paul)   +9 more
core   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead. [PDF]

, 2015
Lifestyle factors are responsible for a considerable portion of cancer incidence worldwide, but credible estimates from the World Health Organization and the International Agency for Research on Cancer (IARC) suggest that the fraction of cancers ...
Ab Hamid, Hasiah, Abd Hamid, Roslida, Ahmed, Nuzhat, Al-Mulla, Fahd, Al-Temaimi, Rabeah, Ali, Abdul Manaf, Amedei, Amedeo, Andrade-Vieira, Rafaela, Azqueta, Amaya, Baglole, Carolyn J., Barclay, Barry J., Bay, Sarah N., Berg, Arthur, Bisson, William H., Blanco-Aparicio, Carmen, Brooks, Samira A., Brown, Dustin G., Brunborg, Gunnar, Calaf, Gloria M., Carlin, Danielle J., Carnero, Amancio, Carpenter, David O., Casey, Stephanie C., Castellino, Robert C., Chapellier, Marion, Charles, Amelia K., Chen, Tao, Chen, Zhenbang, Cheng, Qiang (Shawn), Chiaradonna, Ferdinando, Christopher, Joseph A., Cohen-Solal, Karine A., Colacci, Annamaria, Collins, Andrew R., Corsini, Emanuela, Cruickshanks, Nichola, Curran, Colleen S., D'Abronzo, Leandro S., Darbre, Philippa, Darroudi, Firouz, de Cerain Salsamendi, Adela Lopez, Decker, William K., Dent, Paul, Di Fiore, Riccardo, Dong, Chenfang, Dormoy, Valerian, Dornetshuber-Fleiss, Rita, Eltom, Sakina, Engstrom, Wilhelm, Eriksson, Staffan, Felsher, Dean W., Fernando Martinez-Leal, Juan, Forte, Stefano, Ghosh, Paramita M., Gilbertson, Michael, Goldberg, Gary S., Gonzalez, Laetitia, Gonzalez, Michael J., Goodson, William H, Guarnieri, Tiziana, Gulliver, Linda, Harris, Shelley A., Heneberg, Petr, Hsu, Chia-Wen, Hsu, Hsue-Yin, Hu, Zhiwei, Hultman, Tove, III, Jian, Le, Karamouzis, Michalis V., Khatami, Mahin, Kirsch-Volders, Micheline, Klaunig, James E., Kleinstreuer, Nicole, Koch, Daniel C., Kondoh, Hiroshi, Koppen, Gudrun, Koturbash, Igor, Kravchenko, Julia, Krishnakumar, P. K., Krishnan, Harini, Kuemmerle, Nancy B., Laconi, Ezio, Laird, Dale W., Langie, Sabine A. S., Lasfar, Ahmed, Lee, Tae-Jin, Leung, Po Sing, Leyns, Luc, Li, Lin, Lin, Liang-Tzung, Lleonart, Matilde, Lowe, Leroy, Luanpitpong, Sudjit, Luqmani, Yunus, Lyerly, H. Kim, Maguer-Satta, Veronique, Manjili, Masoud H., Marignani, Paola A., Marongiu, Fabio, Martin, Francis L., Massfelder, Thierry, McCawley, Lisa J., Mehta, Rekha, Memeo, Lorenzo, Miousse, Isabelle R., Mondello, Chiara, Moon, Eun-Yi, Moorwood, Kim, Nahta, Rita, Nangami, Gladys, Nangia-Makker, Pratima, Narayanan, Kannan Badri, Naus, Christian C., Ochieng, Josiah, Odero-Marah, Valerie, Ogunkua, Olugbemiga, Olsen, Ann-Karin, Ostrosky-Wegman, Patricia, Otsuki, Takemi, Palorini, Roberta, Papagerakis, Silvana, Park, Hyun Ho, Pavanello, Sofia, Ponce-Cusi, Richard, Prudhomme, Kalan R., Raju, Jayadev, Rathmell, W. Kimryn, Ratovitski, Edward, Robey, R. Brooks, Rojanasakul, Yon, Rojas, Emilio, Roman, Jesse, Romano, Maria Fiammetta, Romano, Simona, Roy, Debasish, Roy, Rabindra, Ryan, Elizabeth P., Ryeom, Sandra, Sabbisetti, Venkata, Salem, Hosni K., Salzberg, Anna C., Sanderson, Thomas, Scovassi, A. Ivana, Singh, Neetu, Sinha, Ranjeet K., Sone, Hideko, Soucek, Laura, Sun, Jun, Thompson, Patricia, Vaccari, Monica, Vadgama, Pankaj, Valverde, Mahara, van Larebeke, Nik, Van Schooten, Frederik J., Vento, Renza, Vermeulen, Louis, Vondracek, Jan, Wade, Mark, Wagemaker, Gerard, Ward, Andrew, Weisz, Judith, Whitfield, Jonathan R., Williams, Graeme, Williams, Marc A., Wise, John Pierce, Sr., Wise, Sandra S., Wolf, Gregory T., Woodrick, Jordan, Xia, Menghang, Yasaei, Hemad, Yedjou, Clement, Zhang, Luoping, Zhou, Binhua P.   +173 more
core   +11 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

HTX-011 reduced pain intensity and opioid consumption versus bupivacaine HCl in bunionectomy: phase III results from the randomized EPOCH 1 study. [PDF]

, 2019
BACKGROUND AND OBJECTIVES: There is a need for local anesthetics that provide consistent analgesia through 72 hours after surgery. This study evaluates the use of HTX-011 (bupivacaine and meloxicam in Biochronomerpolymer technology), an extended-release,
Gimbel, Joseph S., Hu, Jia, Lee, Gwo-Chin, Pollack, Richard A., Viscusi, Eugene R.   +4 more
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source