Results 131 to 140 of about 4,164,802 (316)

Reference Pricing Versus Co-Payment in the Pharmaceutical Industry: Firm's Pricing Strategies [PDF]

Within a horizontally differentiation model and allowing for heterogeneous qualities, we analyze the effects of reference pricing reimbursement on firms’ pricing strategies. With this analysis we find inherent incentives for firms’ pricing behaviour, and
Marisa Miraldo
core  

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Depth based: No Reference Stereoscopic Image Quality Assessment

Discover Applied Sciences
The transition from 2 to 3D imaging marks a significant technological and conceptual leap across multiple domains, offering depth perception akin to real-world vision.
S. Kiruthika, J. Joshan Athanesious, D. Rushma   +2 more
doaj   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

An experimental analysis of thick-film solid-state reference electrodes

, 2012
Thick-Film planar solid-state Silver/Silver Chloride (Ag/AgCl) reference electrodes were developed and tested for ion susceptibility and long term drift in approximately 0.04 M potassium chloride (KCl) solution.
Sophocleous, Marios, Garcia-Breijo, Eduardo, Atkinson, John Karl, Glanc-Gostkiewicz, Monika   +3 more
core  

Study Algorithms which Assessed Quality of the Blurred Images

مجلة علوم ذي قار, 2019
No-reference measurement of blurring artifacts in images is a difficult problem in image quality assessment field. In this paper, we present a no-reference blur metric to measure the quality of the images.
Radhi Sh. Hamoudi
doaj  

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Children’s knowledge of indefinite and definite reference [PDF]

, 1990
After reviewing previous theoretical and empirical investigations, the decision is made that an understanding of both "Familiarity' and 'Specificity' must be necessary for a full appreciation of indefiniteness/definiteness.
Sims, K.M, Sims, Ceri M., Sims, Kerry. M.   +2 more
core  

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source