Results 141 to 150 of about 184,133 (253)

From accidents to assets—The value pathways of patents for serendipitous inventions

Strategic Management Journal, EarlyView.
Abstract Research Summary Firms often celebrate accidental inventions that lead to major breakthroughs, yet little is known about how the value of serendipitous inventions materializes. Using data from 8530 patented inventions across 23 countries, our research shows that these inventions differ from planned R&D outcomes.
Christoph Grimpe, Karin Hoisl, Myriam Mariani, Wolfgang Sofka   +3 more
wiley   +1 more source

Regulatory T cells: the 2025 Nobel prize in physiology or medicine. [PDF]

Ups J Med Sci
Singh K.
europepmc   +1 more source

The 2022 Nobel Prize in Chemistry-sweet! [PDF]

Glycobiology, 2023
Boyce M, Malaker SA, Riley NM, Kohler JJ.   +3 more
europepmc   +1 more source

Ultrasensitive MicroRNA Detection Combining Reduced Graphene Oxide Electrolyte‐Gated Transistors and Machine Learning

Small, EarlyView.
We developed an ultrasensitive and highly selective biosensor by integrating bio‐functionalized reduced graphene oxide (rGO) electrolyte‐gated transistors (EGTs) and machine learning (ML) to detect miRNAs (miR‐34a, miR‐34b, and miR‐34c) associated with cancer and neurological disorders.
Ana Vitória Ferreira Deleigo, Gabrielle Coelho Lelis, Maria Luisa Braunger, Stefano Casalini, Yasmin Watanabe, Gabriel Ravanhani Schleder, Wilson Tiago Fonseca, Rafael Furlan de Oliveira   +7 more
wiley   +1 more source

Why Did Treg and Immune Tolerance Win Nobel Prize This Year? [PDF]

Genomics Proteomics Bioinformatics
Zheng 郑颂国 SG.
europepmc   +1 more source

Seeded Growth of Plasmonic Core‐Shell NU‐1000 NanoMOFs With Intracellular Optical Readout

Small, EarlyView.
Seed‐mediated growth yields plasmonic core‐shell nanocomposites by encapsulating gold nanoparticles within NU‐1000 nanoMOFs, preserving morphology and optical response. The materials exhibit tunable photoluminescence quenching, efficient photothermal heating, and SERS activity.
Manuel Ceballos, Oleg Semyonov, Enrica Soprano, Ethan Kensett, José Manuel Vila‐Fungueiriño, Timothy M. Craig, Sara Bals, Ester Polo, Beatriz Pelaz, Pablo del Pino   +9 more
wiley   +1 more source

The 2025 Nobel Prize in Physiology or Medicine - a bridge to peripheral immune tolerance. [PDF]

J Clin Invest
Bluestone JA.
europepmc   +1 more source

Design, synthesis and activity evaluation of tetrahydroisoquinoline‐based programmed cell death ligand 1 inhibitors

Smart Molecules, EarlyView.
Based on a 3D‐quantitative structure‐activity relationship pharmacophore model, structural optimization of Y6 yielded Y7f. Mechanistic studies revealed that Y7f acted as a programmed death receptor 1/programmed cell death ligand 1 (PD‐L1) interaction inhibitor by inducing PD‐L1 dimerization. Y7f restored T‐cell function.
Menglin Yu, Sen Cai, Yanyan Pan, Heshuang Wang, Fengwu Zhang, Aiyu Ma, Shixuan Lv, Xiuhan Guo, Shisheng Wang, Qiling Song, Chunyan Ma, Shuai Wang, Li Zhang, Jian Wang, Qingwei Meng, Yueqing Li   +15 more
wiley   +1 more source

An education in tolerance: the 2025 Nobel Prize in Physiology or Medicine. [PDF]

Dis Model Mech
Liston A.
europepmc   +1 more source

The Nobel Prize awarded to pioneers of mRNA vaccines. [PDF]

Mol Ther, 2023
Herzog RW, Giangrande PH.
europepmc   +1 more source