Results 51 to 60 of about 4,072 (175)

Placebo and nocebo in clinical practice: An online cross-sectional survey of healthcare professionals from European countries on views, practices and training needs.

PLoS ONE
BackgroundPlacebo and nocebo effects significantly influence health outcomes, yet healthcare professionals receive limited training and guidance on their mechanisms and clinical application, creating a gap in education and practical understanding ...
Mary O'Keeffe, Nathan Skidmore, Arianna Bagnis, Przemysław Bąbel, Elżbieta A Bajcar, Alessandra De Palma, Andrea W M Evers, Eveliina Glogan, Julia W Haas, Stefanie H Meeuwis, Marek Oleszczyk, Antonio Portolés, Johan W S Vlaeyen, Katia Mattarozzi, PANACEA Consortium   +14 more
doaj   +1 more source

Placebo and nocebo phenomena from the perspective of evidence based and person centered medicine [PDF]

Hospital Pharmacology, 2017
Introduction: Placebo and nocebo phenomena in pharmacology are very important, but controversial issues from the perspective of evidence-based medicine (EBM) in many ways.
Jakovljević Miro I.
doaj   +1 more source

Resisting Contagious Hopelessness: Therapeutic Alliance and the Limits of Physician‐Assisted Death in Severe and Enduring Anorexia Nervosa

Psychiatric Research and Clinical Practice, EarlyView.
Contemporary psychiatric ethics emphasize autonomy and shared decision‐making, yet these frameworks may be strained in severe mental illnesses characterized by cognitive rigidity, fluctuating decisional capacity, and undue clinician influence. Severe and enduring anorexia nervosa serves as a case example to explore how therapeutic alliance, clinician ...
Elizabeth M. Olson, Fabian M. Saleh, Angela S. Guarda   +2 more
wiley   +1 more source

The Other Side of the Coin: Nocebo Effects and Psychotherapy

Frontiers in Psychiatry, 2019
Psychotherapy and placebo have a long history, and both have been shown to have significant and clinically meaningful effects. In the last 100 years and up to today, psychotherapy has been subject to an enduring and often heated debate about its ...
Cosima Locher, Cosima Locher, Helen Koechlin, Helen Koechlin, Jens Gaab, Heike Gerger   +5 more
doaj   +1 more source

Comparative Effectiveness Analysis of Phase 3 Clinical Trials in Moderately to Severely Active Inflammatory Bowel Disease Reveals Increased Harm From Placebo and Challenges Equipoise

JCC Plus, Volume 1, Issue 5, September 2026.
Across 47 Phase 3 trials in Crohn's disease and ulcerative colitis, placebo exposure was associated with measurable harm. Disease exacerbation events showed the greatest excess risk, with one additional exacerbation occurring for every 8–13 patients assigned to placebo rather than active therapy.
Joëlle St‐Pierre, Zachary D. Fine, Evan N. Fear, Jeremy A. Klein, Natalie K. Choi, David T. Rubin   +5 more
wiley   +1 more source

Personality Differences of Brain Networks in Placebo Analgesia and Nocebo Hyperalgesia: A Psychophysiological Interaction (PPI) Approach in fMRI

Neural Plasticity, 2020
It is generally believed that the placebo response can elicit an analgesic effect, whilst the nocebo response can elicit a hyperalgesia effect in pain. Placebo analgesia and nocebo hyperalgesia effects are increasing concerns for researchers.
Yu Shi, Shimin Huang, Hongrui Zhan, Yaping Wang, Yanyan Zeng, Guiyuan Cai, Jianming Yang, Wen Wu   +7 more
doaj   +1 more source

Lost in Translation: Why Biologic Therapies for Intervertebral Disc Degeneration and Low Back Pain Have Not Reached the Clinic (Yet)

JOR SPINE, Volume 9, Issue 3, September 2026.
From preclinical promise to clinical translation in intervertebral disc degeneration (IDD). Robust preclinical evidence supports a range of biologic therapies, with consistent improvements in imaging, extracellular matrix composition, inflammation, and behavior.
Luca Ambrosio, Jordy Schol, Clara Ruiz‐Fernandez, Vincenzo Denaro, Gianluca Vadalà, Daisuke Sakai   +5 more
wiley   +1 more source

A Qualitative Systematic Review of Effects of Provider Characteristics and Nonverbal Behavior on Pain, and Placebo and Nocebo Effects

Frontiers in Psychiatry, 2019
Background: Previous research has indicated that the sex, status, and nonverbal behaviors of experimenters or clinicians can contribute to reported pain, and placebo and nocebo effects in patients or research participants.
Hojjat Daniali, Magne Arve Flaten
doaj   +1 more source

Differential Impact of Pharmacokinetic and Pharmacodynamic Variability on Response to Combination Therapy

Pharmacology Research &Perspectives, Volume 14, Issue 4, August 2026.
ABSTRACT Interindividual variability (IIV) in drug response complicates both fixed‐dose design and individualized therapy. Understanding how pharmacokinetic (PK) and pharmacodynamic (PD) processes jointly shape this variability is essential, particularly in combination therapy, where multiple interacting pathways influence outcomes. This study employed
Kuteesa R. Bisaso, Ronald Kadada Karyaburo, Jackson K. Mukonzo, Ene I. Ette   +3 more
wiley   +1 more source

Relational Autonomy, Maternalism, and the Nocebo Effect [PDF]

The American Journal of Bioethics, 2017
In their target article, Menkes et al. suggest that the nocebo effect, in which an individual experiences an adverse effect of medical treatment due to negative expectations, occasions a dilemma between autonomy and nonmaleficence. They work to resolve the dilemma by arguing that in some cases, nonmaleficence outweighs autonomy.
Specker Sullivan, Laura, Niker, Fay
openaire   +4 more sources