Minimizing Drug Adverse Events by Informing About the Nocebo Effect—An Experimental Study [PDF]
Frontiers in Psychiatry, 2019 Relevance: Informing patients about potential adverse events as part of the informed consent may facilitate the development of nocebo-driven drug adverse events (nocebo side effects).Objective: To investigate whether informing about the nocebo effect ...
Yiqi Pan +4 more
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The nocebo effect of drugs. [PDF]
Pharmacol Res Perspect, 2016 AbstractWhile the placebo effect has been studied for a long time, much less is known about its negative counterpart, named the nocebo effect. However, it may be of particular importance because of its impact on the treatment outcomes and public health. We conducted a review on the nocebo effect using PubMed and other databases up to July 2014.
Planès S, Villier C, Mallaret M.
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Minimizing nocebo effect: Pragmatic approach
Avicenna Journal of Medicine, 2017 The nocebo effect, the inverse of the placebo effect, is a well-established phenomenon, yet under-appreciated. It refers to nonpharmacological, harmful, or undesirable effects occurring after active or inactive therapy.
Majed Chamsi Pasha +2 more
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Psychological distress, perceived stress and nocebo effect (multifood adverse reaction) in irritable bowel syndrome patients [PDF]
Journal of Education and Health Promotion, 2023 BACKGROUND: Psychological distress and perceived stress may complicate the clinical presentation, course, and treatment of patients with functional gastrointestinal disorders.
Hamid Nasiri-Dehsorkhi +3 more
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Informing About the Nocebo Effect Affects Patients’ Need for Information About Antidepressants—An Experimental Online Study [PDF]
Frontiers in Psychiatry, 2021 Relevance: Understanding patients’ informational needs and adapting drug-related information are the prerequisites for a contextualized informed consent. Current information practices might rather harm by inducing nocebo effects.Objective: To investigate
Yvonne Nestoriuc +6 more
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Annu Rev Pharmacol ToxicolAdverse nocebo responses can cause harm to patients and interfere with treatment adherence and effects in both clinic practice and clinical trials. Nocebo responses refer to negative outcomes to active medical treatments in clinical trials or practice that cannot be explained by the treatment's pharmacologic effects.
Colloca L.
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The nocebo effect as a source of bias in the assessment of treatment effects [version 2; peer review: 1 approved, 2 approved with reservations] [PDF]
F1000Research, 2019 The term nocebo effect refers to the harmful outcomes that result from people’s negative beliefs, anticipations, or experiences related to the treatment rather than the pharmacological properties of the treatment.
Karolina Wartolowska
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Nonmedical Switching From Originators to Biosimilars: Does the Nocebo Effect Explain Treatment Failures and Adverse Events in Rheumatology and Gastroenterology? [PDF]
Rheumatology and Therapy, 2020 The act of nonmedical switching, defined as switching stable patients who are generally doing well with their current therapy from an originator biologic to its biosimilar, has been endorsed as a reasonable treatment strategy.
Roy Fleischmann +4 more
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Preventing adverse events of chemotherapy for gastrointestinal cancer by educating patients about the nocebo effect: a randomized-controlled trial [PDF]
BMC Cancer, 2022 Background Adverse events of chemotherapy may be caused by pharmacodynamics or psychological factors such as negative expectations, which constitute nocebo effects. In a randomized controlled trial, we examined whether educating patients about the nocebo
T. Michnevich +5 more
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Differential Classical Conditioning of the Nocebo Effect: Increasing Heat-Pain Perception without Verbal Suggestions [PDF]
Frontiers in Psychology, 2017 Background: Nocebo effects, including nocebo hyperalgesia, are a common phenomenon in clinical routine with manifold negative consequences. Both explicit expectations and learning by conditioning are known to induce nocebo effects, but the specific role ...
Anne-Kathrin Bräscher +7 more
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