Minimizing nocebo effect: Pragmatic approach [PDF]
Avicenna Journal of Medicine, 2017 The nocebo effect, the inverse of the placebo effect, is a well-established phenomenon, yet under-appreciated. It refers to nonpharmacological, harmful, or undesirable effects occurring after active or inactive therapy.
Majed Chamsi Pasha +2 more
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The nocebo effect as a source of bias in the assessment of treatment effects [version 2; peer review: 1 approved, 2 approved with reservations] [PDF]
F1000Research, 2019 The term nocebo effect refers to the harmful outcomes that result from people’s negative beliefs, anticipations, or experiences related to the treatment rather than the pharmacological properties of the treatment.
Karolina Wartolowska
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Psychological distress, perceived stress and nocebo effect (multifood adverse reaction) in irritable bowel syndrome patients [PDF]
Journal of Education and Health Promotion, 2023 BACKGROUND: Psychological distress and perceived stress may complicate the clinical presentation, course, and treatment of patients with functional gastrointestinal disorders.
Hamid Nasiri-Dehsorkhi +3 more
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What is the nocebo effect and does it apply to dentistry? : A narrative review [PDF]
J Oral Rehabil, 2022 Evidence for the nocebo effect, a phenomenon characterised by suboptimal treatment efficacy, worsening of symptoms, or the occurrence of adverse events caused by an individual's negative treatment expectations, is growing across a multitude of medical ...
Watanabe, Takeshi, +21 more
core +2 more sources
Minimizing Drug Adverse Events by Informing About the Nocebo Effect—An Experimental Study [PDF]
Frontiers in Psychiatry, 2019 Relevance: Informing patients about potential adverse events as part of the informed consent may facilitate the development of nocebo-driven drug adverse events (nocebo side effects).Objective: To investigate whether informing about the nocebo effect ...
Yiqi Pan +4 more
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Annual Review of Pharmacology and ToxicologyAdverse nocebo responses can cause harm to patients and interfere with treatment adherence and effects in both clinic practice and clinical trials. Nocebo responses refer to negative outcomes to active medical treatments in clinical trials or practice that cannot be explained by the treatment's pharmacologic effects.
Colloca L.
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Nonmedical Switching From Originators to Biosimilars: Does the Nocebo Effect Explain Treatment Failures and Adverse Events in Rheumatology and Gastroenterology? [PDF]
Rheumatology and Therapy, 2020 The act of nonmedical switching, defined as switching stable patients who are generally doing well with their current therapy from an originator biologic to its biosimilar, has been endorsed as a reasonable treatment strategy.
Roy Fleischmann +4 more
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Preventing adverse events of chemotherapy for gastrointestinal cancer by educating patients about the nocebo effect: a randomized-controlled trial [PDF]
BMC Cancer, 2022 Background Adverse events of chemotherapy may be caused by pharmacodynamics or psychological factors such as negative expectations, which constitute nocebo effects. In a randomized controlled trial, we examined whether educating patients about the nocebo
T. Michnevich +5 more
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Fear of pain potentiates nocebo hyperalgesia [PDF]
Journal of Pain Research, 2015 Per M Aslaksen,1 Peter S Lyby2 1Department of Psychology, Research Group for Cognitive Neuroscience, The Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø, Norway; 2Catosenteret Rehabilitation Center,
Aslaksen PM, Lyby PS
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Placebo and nocebo effects on pain through the lens of the predictive brain: Neurobiological mechanisms and translational implications [PDF]
Experimental Physiology, EarlyView.Abstract Placebo and nocebo effects on pain provide a model for investigating how cognitive and contextual factors modulate the physiological processes underlying nociception and its regulation. However, existing accounts remain fragmented and lack a unifying mechanistic framework linking brain, behaviour and autonomic responses.
Denisa Adina Zamfira +4 more
wiley +2 more sources