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Just Say No…to the Nocebo Effect
Biosimilars are highly similar products of an innovator biologic used to decrease costs. The nocebo effect is an increase in symptoms resulting from a patient’s negative perceptions about a biosimilar. Multistep notification, organized transition, and opt-out ability constitute a framework for switching patients from a reference product to a biosimilar.
Leah, Rossmann, Raymond K, Cross
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Improving the Understanding and Measurement of the Nocebo Effect [PDF]
Unexplained adverse reactions are a common result of medical treatments and interventions. These responses are often suggestive of the nocebo effect but to date little research has examined the underlying environment of real-life health events that ...
MacKrill, Kate Madeleine
core
The exacerbation of a clinical condition or the occurrence of negative symptoms after an inert substance dispensation or a sham treatment is known as “nocebo effect.” Nocebo is the psychobiological effect due to the negative psychosocial context that ...
Martina Amanzio +3 more
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Background: Conditioning is a key mechanism of placebo and nocebo effects in adults. Little is known about the underlying mechanisms of placebo and nocebo effects in youth and how they might be influenced by conscious awareness and cognitive abilities ...
Regula Neuenschwander +5 more
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Background: Positive expectations (i.e., placebo effect) can improve postural control during quiet standing. This raises an important question: if postural control is susceptible to positive expectations, is it possible to elicit the opposite, a decline ...
Katherine Russell +5 more
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Placebo and the law of identification
Thousands of essays and studies have been published on placebo and nocebo. Yet, despite this plethora of information, we are not much closer to a comprehensive understanding of the fundamental mechanism producing placebo and nocebo effects than we were ...
Steve F. Bierman +2 more
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The Nocebo Effect in Childbirth Classes [PDF]
Patients are well-known to experience a placebo response to medications or treatments. It is less well-known that they can also experience a nocebo response where they have negative effects from something that should be ineffective. In recent literature, the words of medical providers have been demonstrated to create illness responses without physical ...
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Abstract Objectives Adalimumab biosimilars are as safe and effective compared to the originator. Adult patients with inflammatory bowel disease (IBD) who switched to a biosimilar have comparable outcomes, but pediatric data are limited. This study evaluates clinical outcomes of children and young adults with IBD following a nonmedical, insurance‐driven
Daniel Himelstein +5 more
wiley +1 more source
Underappreciated power. Placebo and nocebo in medicine
The term placebo is defined as a substance with no therapeutic effect that improves health by convincing the patient that the substance is effective. The term comes from the Latin “placere”, meaning “I will delight” or “do good”.
A. O. Bueverov
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ObjectiveTo estimate the magnitude of the nocebo response and explore its influencing factors in irritable bowel syndrome (IBS).MethodsThe PubMed, Embase, and Cochrane Library databases were searched up to March 2021.
Ruijie Li +9 more
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