Nocebo response intensity and influencing factors in the randomized clinical trials of irritable bowel syndrome: A systematic review and meta-analysis [PDF]
Frontiers in Medicine, 2022 ObjectiveTo estimate the magnitude of the nocebo response and explore its influencing factors in irritable bowel syndrome (IBS).MethodsThe PubMed, Embase, and Cochrane Library databases were searched up to March 2021.
Ruijie Li +9 more
doaj +4 more sources
The Placebo and Nocebo Responses in Clinical Trials in Inflammatory Bowel Diseases [PDF]
Frontiers in Pharmacology, 2021 Placebo and nocebo responses are mostly discussed in clinical trials with functional bowel disorders. Much less has been investigated and is known in gastrointestinal diseases beyond irritable bowel syndrome (IBS), especially in inflammatory bowel ...
Paul Enck, Sibylle Klosterhalfen
doaj +3 more sources
Nocebo hyperalgesia and the startle response [PDF]
Neuroscience, 2016 The literature on the effects of nocebo on pain is sparse. The present experimental study investigated whether suggestions of nocebo hyperalgesia modified the startle response and whether increased startle contributed to the nocebo hyperalgesic effect.A design with four groups was employed; the participants were randomized into either a placebo group ...
Per M Aslaksen, Espen Bjørkedal
exaly +4 more sources
The influence of personality traits on the placebo/nocebo response [PDF]
Journal of Psychosomatic Research, 2020 Objective: Some people might be more prone to placebo and nocebo responses than others depending on their personality traits. We aimed to provide a systematic review on the influence of personality traits on placebo and nocebo responses in controlled and uncontrolled studies. Methods: We conducted a systematic literature search in the databases CINAHL,
Alexandra Kern +2 more
exaly +2 more sources
No Reason to Feel Sick? Nocebo Responses in the Placebo Arms of Experimental Endotoxemia Studies [PDF]
Frontiers in Psychiatry, 2019 Adverse side effects are reported by a large proportion of patients undergoing medical treatment in clinical practice or clinical trials. Nocebo effects, induced by negative treatment expectancies, can contribute to negative patient-reported outcomes but
Sven Benson, Sigrid Elsenbruch
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Bad Is More Powerful than Good: The Nocebo Response in Medical Consultations [PDF]
American Journal of Medicine, 2015 Although there has been a lot of research looking at the placebo response, nocebo responses in the healthcare setting have been largely overlooked. This article explores the potential role of negative patient-doctor communication in facilitating nocebo responses in the medical consultation. We suggest that invalidation, that is, communicating a lack of
Maddy Greville-Harris, Paul Dieppe
exaly +5 more sources
The concept of placebo/nocebo response and effect
EULAR Rheumatology Open: The placebo response is different from the placebo effect. Whereas the placebo response is the global response to a placebo, including spontaneous remission, regression to the mean, patients’ and experimenters’ biases, possible effects of ...
Fabrizio Benedetti
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Effect of enhanced support for coping with side effects during medication counselling on the nocebo effect in patients with advanced lung cancer receiving initial chemotherapy: protocol for a multicentre exploratory open-label randomised controlled trial [PDF]
BMJ OpenIntroduction Chemotherapy-induced nausea and vomiting (CINV) is a common symptom in cancer, and it is one of the distressing symptoms in patients with cancer receiving chemotherapy.
Yoshinobu Matsuda +6 more
doaj +2 more sources
Nocebo in Biosimilars and Generics in Neurology: A Systematic Review
Frontiers in Pharmacology, 2019 Background: Nocebo refers to adverse events related to patients’ negative expectations and previous experiences, mediated by several neurobiological pathways within the brain.
Ioanna Spanou +2 more
doaj +3 more sources
The High-Risk Model of Threat Perception Modulates Learning of Placebo and Nocebo Effects and Functional Somatic Disorders [PDF]
Brain SciencesThreat activation or deactivation in the brain–body is associated with learned nocebo or placebo somatic effects induced by fake invasive medical–surgical procedures.
Ian Wickramasekera
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