Results 41 to 50 of about 3,456 (197)

Preventing adverse events of chemotherapy for gastrointestinal cancer by educating patients about the nocebo effect: a randomized-controlled trial

BMC Cancer, 2022
Background Adverse events of chemotherapy may be caused by pharmacodynamics or psychological factors such as negative expectations, which constitute nocebo effects. In a randomized controlled trial, we examined whether educating patients about the nocebo
T. Michnevich, Y. Pan, A. Hendi, K. Oechsle, A. Stein, Y. Nestoriuc   +5 more
doaj   +1 more source

A neural mechanism of direct and observational conditioning for placebo and nocebo responses [PDF]

NeuroImage, 2019
Classical theories suggest placebo analgesia and nocebo hyperalgesia are based on expectation and conditioned experience. Whereas the neural mechanism of how expectation modulates placebo and nocebo effects during pain anticipation have been extensively studied, little is known about how experience may change brain networks to produce placebo and ...
Yiheng Tu, Joel Park, Seppo P. Ahlfors, Sheraz Khan 0002, Natalia Egorova, Courtney Amanda Lang, Jin Cao, Jian Kong   +7 more
openaire   +3 more sources

Nonmedical Switching From Originators to Biosimilars: Does the Nocebo Effect Explain Treatment Failures and Adverse Events in Rheumatology and Gastroenterology?

Rheumatology and Therapy, 2020
The act of nonmedical switching, defined as switching stable patients who are generally doing well with their current therapy from an originator biologic to its biosimilar, has been endorsed as a reasonable treatment strategy.
Roy Fleischmann, Vipul Jairath, Eduardo Mysler, Dave Nicholls, Paul Declerck   +4 more
doaj   +1 more source

Placebo and Nocebo Effects Are Defined by Opposite Opioid and Dopaminergic Responses [PDF]

Archives of General Psychiatry, 2008
Placebo and nocebo effects, the therapeutic and adverse effects, respectively, of inert substances or sham procedures, represent serious confounds in the evaluation of therapeutic interventions. They are also an example of cognitive processes, particularly expectations, capable of influencing physiology.To examine the contribution of 2 different ...
David J, Scott, Christian S, Stohler, Christine M, Egnatuk, Heng, Wang, Robert A, Koeppe, Jon-Kar, Zubieta   +5 more
openaire   +2 more sources

Does Sex/Gender Play a Role in Placebo and Nocebo Effects? Conflicting Evidence From Clinical Trials and Experimental Studies

Frontiers in Neuroscience, 2019
Sex has been speculated to be a predictor of the placebo and nocebo effect for many years, but whether this holds true or not has rarely been investigated.
Paul Enck, Sibylle Klosterhalfen
doaj   +1 more source

Influence of the behaviour pattern on the nocebo response of healthy volunteers. [PDF]

British Journal of Clinical Pharmacology, 1995
The occurrence of a nocebo effect after placebo administration to healthy volunteers in a Phase I trial was analysed according to their type of personality (Bortner Rating Scale). More subjects with a behaviour pattern A (competitive and aggressive) (50%) described subjective side effects of the placebo than type B subjects (17%, P = 0.03).
M D, Drici, F, Raybaud, C, De Lunardo, P, Iacono, P, Gustovic   +4 more
openaire   +2 more sources

Putting the ‘Art’ Into the ‘Art of Medicine’: The Under-Explored Role of Artifacts in Placebo Studies

Frontiers in Psychology, 2020
Research in social psychology demonstrates that physical environmental factors – or “artifacts” such as provider clothing and office décor – can influence health outcomes.
Michael H. Bernstein, Cosima Locher, Cosima Locher, Tobias Kube, Tobias Kube, Sarah Buergler, Sif Stewart-Ferrer, Charlotte Blease, Charlotte Blease   +8 more
doaj   +1 more source

Induction and generalization of nocebo effects on itch

, 2022
Nocebo effects, that is, negative treatment outcomes due to negative expectancies, can increase itch. Moreover, indirect evidence has shown that nocebo hyperknesis can generalize to another itch modality.
Evers, Andrea W. M., van Laarhoven, Antoinette I.M., Weng, Lingling, Weng, Lingling (author), Peerdeman, Kaya J. (author), Evers, A.W.M. (author), Peerdeman, Kaya J., Evers, A.W.M., van Laarhoven, Antoinette I. M., van Laarhoven, Antoinette I.M. (author)   +9 more
core   +1 more source

The Effect of Positive Therapeutic Communication on Pain (POPAIN) and Anxiety During Arterial Blood Gas Standardized Procedures in the Emergency Department Compared to Traditional Communication: Protocol for a Monocentric Randomized Controlled Trial

JMIR Research Protocols, 2023
BackgroundIn the emergency department (ED), medical procedures, such as arterial blood gas (ABG) testing, can cause pain and high stress levels.
Thomas Schmutz, Christophe Le Terrier, Vincent Ribordy, Katia Iglesias, Youcef Guechi   +4 more
doaj   +1 more source

The placebo response rate and nocebo events in obesity pharmacological trials. A systematic review and meta-analysis

EClinicalMedicine, 2022
Summary: Background: There is a growing number of trials examining the effectiveness of pharmacotherapies for obesity, however, little is known about placebo and nocebo effect in these trials. Hence, we sought to examine the effect of placebo in obesity
Yip Han Chin, Cheng Han Ng, Nicholas WS Chew, Gwyneth Kong, Wen Hui Lim, Darren Jun Hao Tan, Kai En Chan, Ansel Tang, Daniel Q Huang, Mark Y Chan, Gemma Figtree, Jiong-Wei Wang, Asim Shabbir, Chin Meng Khoo, Vincent Wai-Sun Wong, Dan Yock Young, Mohammad Shadab Siddiqui, Mazen Noureddin, Arun Sanyal, David E. Cummings, Nicholas Syn, Mark Dhinesh Muthiah   +21 more
doaj   +1 more source