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Neural Predictors of the Antidepressant Placebo Response
Pharmaceuticals, 2019 The antidepressant placebo response remains a barrier to the development of novel therapies for depression, despite decades of efforts to identify and methodologically address its clinical correlates.
Danielle Rette +3 more
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Frontiers in Immunology, 2021 This study aimed to develop a placebo response model for pharmaceutical clinical trials of primary Sjogren’s syndrome,and to quantitatively analyze the distribution and related factors influencing the placebo response to further optimize the design of ...
ZHI-Zhou Wang +3 more
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Frontiers in Psychology, 2023 IntroductionPlacebo responsiveness is highly variable across individuals. In the domain of pain, it may range from pronounced hypoalgesia to no response at all.
Helena Hartmann +5 more
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Frontiers in Psychiatry, 2023 IntroductionVasomotor symptoms, or hot flashes, are among the most common complaints for menopausal and postmenopausal women. As an alternative to hormone replacement therapy, paroxetine mesylate became the only non-hormonal treatment approved by the U.S.
Joshua R. Rhodes +2 more
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European Headache Federation recommendations for placebo and nocebo terminology
The Journal of Headache and Pain, 2020 Background and aim Despite recent publications, practitioners remain unfamiliar with the current terminology related to the placebo and nocebo phenomena observed in clinical trials and practice, nor with the factors that modulate them.
Dimos D. Mitsikostas +17 more
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Frontal alpha asymmetry: A potential biomarker of approach-withdrawal motivation towards pain
Frontiers in Pain Research, 2022 Pain-related catastrophising is a maladaptive coping strategy known to have a strong influence on clinical pain outcomes and treatment efficacy. Notwithstanding, little is known about its neurophysiological correlates.
Bárbara Silva-Passadouro +8 more
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On the Relationship Between Pain Variability and Relief in Randomized Clinical Trials
Frontiers in Pain Research, 2022 Previous research reports suggest greater baseline variability is associated with greater pain relief in those who receive a placebo. However, studies that evidence this association do not control for confounding effects from regression to the mean and ...
Siddharth R. Tiwari +5 more
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Placebo Effects on Stress, but Not on Pain Reports. A Multi-Experiment Study
Frontiers in Psychology, 2021 BackgroundContextual factors, such as participant/experimenter sex may moderate the placebo effects. We tested whether the participant and experimenter sex modulated placebo effects on experimentally induced pain and associated stress.ObjectiveTo ...
Sara Magelssen Vambheim +2 more
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EClinicalMedicine, 2023 Summary: Background: Spontaneous regression of advanced solid tumors is infrequent but may occur. Quantifying response rates from placebo in cancer drug trials may provide important information for physicians, patients, and regulators.
Arushi Sachdev +4 more
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Placebo Effects in Psychotherapy: A Framework
Frontiers in Psychiatry, 2019 The issue of placebo response and the extent of its effect on psychotherapy is complex for two specific reasons: i) Current standards for drug trials, e.g., true placebo interventions, double-blinding, cannot be applied to most psychotherapy techniques ...
Paul Enck, Stephan Zipfel
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