Results 11 to 20 of about 364,712 (294)

Placebo response in trichotillomania [PDF]

International Clinical Psychopharmacology, 2017
Background: Trichotillomania is a functionally impairing, often overlooked disorder with no FDA-approved medications indicated for its treatment. The ability of clinical trials to detect beneficial effects of pharmacologic treatment in trichotillomania has been hampered by the high placebo response rate.
Grant, Jon E., Chamberlain, Samuel R., Redden, Sarah A., Odlaug, Brian L., Van Ameringen, Michael, Dougherty, Darin D., Keuthen, Nancy J., Kim, Suck W.   +7 more
openaire   +6 more sources

Neural Predictors of the Antidepressant Placebo Response

Pharmaceuticals, 2019
The antidepressant placebo response remains a barrier to the development of novel therapies for depression, despite decades of efforts to identify and methodologically address its clinical correlates.
Danielle Rette, Erin McDonald, Dan V. Iosifescu, Katherine A. Collins   +3 more
doaj   +2 more sources

Brain Connectivity Predicts Placebo Response across Chronic Pain Clinical Trials. [PDF]

PLoS Biology, 2016
Placebo response in the clinical trial setting is poorly understood and alleged to be driven by statistical confounds, and its biological underpinnings are questioned.
Pascal Tétreault, Ali Mansour, Etienne Vachon-Presseau, Thomas J Schnitzer, A Vania Apkarian, Marwan N Baliki   +5 more
doaj   +2 more sources

Predictors of placebo response in peripheral neuropathic pain: insights from pregabalin clinical trials

Journal of Pain Research, 2015
Roy Freeman,1 Birol Emir,2 Bruce Parsons2 1Autonomic and Peripheral Nerve Laboratory, Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, USA; 2Pfizer Inc, New York, NY, USABackground: Greater understanding of factors associated ...
Freeman R, Emir B, Parsons B
doaj   +1 more source

Placebo response in pharmacological trials in patients with functional dyspepsia-A systematic review and meta-analysis. [PDF]

Neurogastroenterol Motil, 2023
Bosman M, Smeets F, Elsenbruch S, Tack J, Simrén M, Talley N, Winkens B, Masclee A, Keszthelyi D.   +8 more
europepmc   +2 more sources

To respond or not to respond: exploring empathy-related psychological and structural brain differences between placebo analgesia responders and non-responders

Frontiers in Psychology, 2023
IntroductionPlacebo responsiveness is highly variable across individuals. In the domain of pain, it may range from pronounced hypoalgesia to no response at all.
Helena Hartmann, Helena Hartmann, Magdalena Banwinkler, Magdalena Banwinkler, Federica Riva, Claus Lamm   +5 more
doaj   +1 more source

European Headache Federation recommendations for placebo and nocebo terminology

The Journal of Headache and Pain, 2020
Background and aim Despite recent publications, practitioners remain unfamiliar with the current terminology related to the placebo and nocebo phenomena observed in clinical trials and practice, nor with the factors that modulate them.
Dimos D. Mitsikostas, Charlotte Blease, Elisa Carlino, Luana Colloca, Andrew L. Geers, Jeremy Howick, Andrea W. M. Evers, Magne A. Flaten, John M. Kelley, Irving Kirsch, Regine Klinger, Antoinette MaassenVanDenBrink, Daniel E. Moerman, Petros P. Sfikakis, Lene Vase, Tor D. Wager, Fabrizio Benedetti, on behalf of the European Headache Federation   +17 more
doaj   +1 more source

Placebo Effects on Stress, but Not on Pain Reports. A Multi-Experiment Study

Frontiers in Psychology, 2021
BackgroundContextual factors, such as participant/experimenter sex may moderate the placebo effects. We tested whether the participant and experimenter sex modulated placebo effects on experimentally induced pain and associated stress.ObjectiveTo ...
Sara Magelssen Vambheim, Hojjat Daniali, Magne Arve Flaten   +2 more
doaj   +1 more source

Frontal alpha asymmetry: A potential biomarker of approach-withdrawal motivation towards pain

Frontiers in Pain Research, 2022
Pain-related catastrophising is a maladaptive coping strategy known to have a strong influence on clinical pain outcomes and treatment efficacy. Notwithstanding, little is known about its neurophysiological correlates.
Bárbara Silva-Passadouro, Bárbara Silva-Passadouro, Ariane Delgado-Sanchez, James Henshaw, Karen Lopez-Diaz, Nelson J. Trujillo-Barreto, Anthony K. P. Jones, Manoj Sivan, Manoj Sivan   +8 more
doaj   +1 more source

On the Relationship Between Pain Variability and Relief in Randomized Clinical Trials

Frontiers in Pain Research, 2022
Previous research reports suggest greater baseline variability is associated with greater pain relief in those who receive a placebo. However, studies that evidence this association do not control for confounding effects from regression to the mean and ...
Siddharth R. Tiwari, Siddharth R. Tiwari, Andrew D. Vigotsky, Andrew D. Vigotsky, A. Vania Apkarian, A. Vania Apkarian   +5 more
doaj   +1 more source