Results 21 to 30 of about 338,657 (254)

Objective response rate of placebo in randomized controlled trials of anticancer medicinesResearch in context

EClinicalMedicine, 2023
Summary: Background: Spontaneous regression of advanced solid tumors is infrequent but may occur. Quantifying response rates from placebo in cancer drug trials may provide important information for physicians, patients, and regulators.
Arushi Sachdev, Isobel Sharpe, Meghan Bowman, Christopher M. Booth, Bishal Gyawali   +4 more
doaj   +1 more source

Placebo Effects in Psychotherapy: A Framework

Frontiers in Psychiatry, 2019
The issue of placebo response and the extent of its effect on psychotherapy is complex for two specific reasons: i) Current standards for drug trials, e.g., true placebo interventions, double-blinding, cannot be applied to most psychotherapy techniques ...
Paul Enck, Stephan Zipfel
doaj   +1 more source

Comparison of indirect treatment methods in migraine prevention to address differences in mode of administration

Journal of Comparative Effectiveness Research, 2023
Aim: Indirect treatment comparisons (ITCs) are anchored on a placebo comparator, and the placebo response may vary according to drug administration route.
Howard Thom, Stephane A Regnier, Xin Ying Lee, Steven Kymes, Lene Vase   +4 more
doaj   +1 more source

Influence on study outcomes of an inpatient study by the behavior of the study staff (PINgPOng): study protocol for a randomized clinical trial

Trials, 2022
Background The placebo effect as the symptom improvement following inert treatments is a fixed component of RCTs to differentiate between specific effects of the tested pharmacological substance from other unspecific effects.
Martin Coenen, Ulrike Bingel, Matthias Zunhammer, Maria Soledad Berdaguer, Christine Fuhrmann, Rolf Fimmers, Jens Rengelshausen, Gunther Hartmann, Manfred Schedlowski, Christoph Coch   +9 more
doaj   +1 more source

Pharmacogenomics and the Placebo Response [PDF]

ACS Chemical Neuroscience, 2018
There is perhaps no more important time in the history of placebos to consider their role in clinical trials and in medicine. Increasingly well-designed pharmaceutical and academic clinical trials testing promising and established drug and surgical interventions have failed to "beat" the placebo response.
Kathryn T, Hall, Joseph, Loscalzo, Ted, Kaptchuk   +2 more
openaire   +2 more sources

Placebo Economics: A Systematic Review About the Economic Potential of Utilizing the Placebo Effect

Frontiers in Psychiatry, 2019
Background: Recent research shows that placebo mechanisms can be utilized in ethical and legal ways such as in open-label conditions, when patients know that they receive placebos, and through psychological interventions aiming to optimize patients ...
Jens Hamberger, Jens Hamberger, Karin Meissner, Karin Meissner, Thilo Hinterberger, Thomas Loew, Katja Weimer   +6 more
doaj   +1 more source

Placebo response and effect in randomized clinical trials: meta-research with focus on contextual effects

Trials, 2021
Background Contextual effects (i.e., placebo response) refer to all health changes resulting from administering an apparently inactive treatment. In a randomized clinical trial (RCT), the overall treatment effect (i.e., the post-treatment effect in the ...
Sigurlaug H. Hafliðadóttir, Carsten B. Juhl, Sabrina M. Nielsen, Marius Henriksen, Ian A. Harris, Henning Bliddal, Robin Christensen   +6 more
doaj   +1 more source

Placebo and the law of identification

Frontiers in Psychiatry
Thousands of essays and studies have been published on placebo and nocebo. Yet, despite this plethora of information, we are not much closer to a comprehensive understanding of the fundamental mechanism producing placebo and nocebo effects than we were ...
Steve F. Bierman, Andrew Weil, Stephen Dahmer   +2 more
doaj   +1 more source

Placebo response in depression

Dialogues in Clinical Neuroscience, 2002
With its naturally fluctuating course, depression is a highly placebo-responsive condition: mean placebo response rates in antidepressant clinical trials are 30% to 40%. We review the history and terminology of placebo and the proposed mechanisms underlying the placebo response, including the physician-patient relationship and biological, sociocultural,
Shamsah B, Sonawalla, Jerrold F, Rosenbaum   +1 more
openaire   +3 more sources

When Your Doctor “Gets It” and “Gets You”: The Critical Role of Competence and Warmth in the Patient–Provider Interaction

Frontiers in Psychiatry, 2019
Background: Research demonstrates that the placebo effect can influence the effectiveness of medical treatments and accounts for a significant proportion of healing in many conditions. However, providers may differ in the degree to which they consciously
Lauren C. Howe, Kari A. Leibowitz, Alia J. Crum   +2 more
doaj   +1 more source