Results 21 to 30 of about 643,840 (294)

Placebo-controlled pharmacological trials in child and adolescents with bipolar disorder manic episode (BPD-ME): Systematic review, meta-analysis and a meta-regression on placebo response (eng)

Klinik Psikiyatri Dergisi, 2020
Objective: Randomized placebo controlled trials (RCT) are very important for testing efficacy and safety of a medical treatment. There is no too much RCT`s in childhood bipolar disorder manic episode.
Remzi Oğulcan Çıray, Pelin Hançer, Mustafa Tunçtürk, Neslihan İnal Emiroğlu   +3 more
doaj   +1 more source

Objective response rate of placebo in randomized controlled trials of anticancer medicinesResearch in context

EClinicalMedicine, 2023
Summary: Background: Spontaneous regression of advanced solid tumors is infrequent but may occur. Quantifying response rates from placebo in cancer drug trials may provide important information for physicians, patients, and regulators.
Arushi Sachdev, Isobel Sharpe, Meghan Bowman, Christopher M. Booth, Bishal Gyawali   +4 more
doaj   +1 more source

Placebo response in trichotillomania [PDF]

International Clinical Psychopharmacology, 2017
Background: Trichotillomania is a functionally impairing, often overlooked disorder with no FDA-approved medications indicated for its treatment. The ability of clinical trials to detect beneficial effects of pharmacologic treatment in trichotillomania has been hampered by the high placebo response rate.
Grant, Jon E., Chamberlain, Samuel R., Redden, Sarah A., Odlaug, Brian L., Van Ameringen, Michael, Dougherty, Darin D., Keuthen, Nancy J., Kim, Suck W.   +7 more
openaire   +4 more sources

Impact of onabotulinumtoxinA on quality of life and practical aspects of daily living : a pooled analysis of two randomized controlled trials [PDF]

, 2015
Objective: To evaluate the impact of onabotulinumtoxinA on individual domains of the quality of life questionnaires in a pooled analysis of two phase 3 trials in overactive bladder patients with urinary incontinence who were inadequately managed by >= 1 ...
Egerdie, Russell B, Everaert, Karel, Greunenfelder, Jennifer, Joshi, Manher, Khalaf, Kristin, Ni, Quanhong, Schulte-Baukloh, Heinrich, Sussman, David   +7 more
core   +2 more sources

Placebo Effects in Psychotherapy: A Framework

Frontiers in Psychiatry, 2019
The issue of placebo response and the extent of its effect on psychotherapy is complex for two specific reasons: i) Current standards for drug trials, e.g., true placebo interventions, double-blinding, cannot be applied to most psychotherapy techniques ...
Paul Enck, Stephan Zipfel
doaj   +1 more source

Comparison of indirect treatment methods in migraine prevention to address differences in mode of administration

Journal of Comparative Effectiveness Research, 2023
Aim: Indirect treatment comparisons (ITCs) are anchored on a placebo comparator, and the placebo response may vary according to drug administration route.
Howard Thom, Stephane A Regnier, Xin Ying Lee, Steven Kymes, Lene Vase   +4 more
doaj   +1 more source

Catechol-O-Methyltransferase val158met Polymorphism Predicts Placebo Effect in Irritable Bowel Syndrome [PDF]

, 2012
Identifying patients who are potential placebo responders has major implications for clinical practice and trial design. Catechol-O-methyltransferase (COMT), an important enzyme in dopamine catabolism plays a key role in processes associated with the ...
Conboy, Lisa Ann, Douaiher, Jeffrey, Hall, Kathryn Tayo, Jensen, Karin, Kaptchuk, Ted Jack, Kelley, John Michael, Kirsch, Irving, Kokkotou, Efi G., Lembo, Anthony J., Ziogas, Dimitrios C.   +9 more
core   +6 more sources

Influence on study outcomes of an inpatient study by the behavior of the study staff (PINgPOng): study protocol for a randomized clinical trial

Trials, 2022
Background The placebo effect as the symptom improvement following inert treatments is a fixed component of RCTs to differentiate between specific effects of the tested pharmacological substance from other unspecific effects.
Martin Coenen, Ulrike Bingel, Matthias Zunhammer, Maria Soledad Berdaguer, Christine Fuhrmann, Rolf Fimmers, Jens Rengelshausen, Gunther Hartmann, Manfred Schedlowski, Christoph Coch   +9 more
doaj   +1 more source

Placebo response and effect in randomized clinical trials: meta-research with focus on contextual effects

Trials, 2021
Background Contextual effects (i.e., placebo response) refer to all health changes resulting from administering an apparently inactive treatment. In a randomized clinical trial (RCT), the overall treatment effect (i.e., the post-treatment effect in the ...
Sigurlaug H. Hafliðadóttir, Carsten B. Juhl, Sabrina M. Nielsen, Marius Henriksen, Ian A. Harris, Henning Bliddal, Robin Christensen   +6 more
doaj   +1 more source

Efficacy and tolerability of adjunctive brivaracetam in patients with prior antiepileptic drug exposure: A post-hoc study. [PDF]

, 2017
Brivaracetam (BRV), a selective, high-affinity ligand for synaptic vesicle protein 2A, is a new antiepileptic drug (AED) for adjunctive treatment of focal (partial-onset) seizures in adults with epilepsy.
Asadi-Pooya, Ali A., Chung, Steve, Diaz, Anyzeila, Elmoufti, Sami, Klein, Pavel, Schiemann, Jimmy, Sperling, Michael R., Whitesides, John   +7 more
core   +2 more sources