Results 31 to 40 of about 364,712 (294)

Pharmacogenomics and the Placebo Response [PDF]

ACS Chemical Neuroscience, 2018
There is perhaps no more important time in the history of placebos to consider their role in clinical trials and in medicine. Increasingly well-designed pharmaceutical and academic clinical trials testing promising and established drug and surgical interventions have failed to "beat" the placebo response.
Kathryn T, Hall, Joseph, Loscalzo, Ted, Kaptchuk   +2 more
openaire   +2 more sources

Placebo Economics: A Systematic Review About the Economic Potential of Utilizing the Placebo Effect

Frontiers in Psychiatry, 2019
Background: Recent research shows that placebo mechanisms can be utilized in ethical and legal ways such as in open-label conditions, when patients know that they receive placebos, and through psychological interventions aiming to optimize patients ...
Jens Hamberger, Jens Hamberger, Karin Meissner, Karin Meissner, Thilo Hinterberger, Thomas Loew, Katja Weimer   +6 more
doaj   +1 more source

Who responds to a placebo? Factors associated with response to placebo during a double-blind randomised controlled trial [PDF]

, 2020
INTRODUCTION: The placebo effect, a desirable outcome resulting from a person’s expected and/or learned response to a treatment or situation, may significantly influence the interpretation of double-blind, randomised controlled trials (RCT). High placebo
Hurst, P., Coleman, D., Saunders, S.
core  

Mirroring everyday clinical practice in clinical trial design: a new concept to improve the external validity of randomized double-blind placebo-controlled trials in the pharmacological treatment of major depression [PDF]

, 2012
Background: Randomized, double-blind, placebo-controlled trials constitute the gold standard in clinical research when testing the efficacy of new psychopharmacological interventions in the treatment of major depression.
Berger Michael, Dittmann, Sandra, Riedel Michael, Sophia, Frangou, Emanuel Severus, Bauer Michael, Severus, Emanuel, Pfennig Andrea, Florian Seemüller, Sophia Frangou, Michael, Bauer, Michael Bauer, Michael Riedel, Berger, Michael, Michael, Obermeier, Andrea, Pfennig, Michael Obermeier, Obermeier Michael, Seemüller Florian, Andrea Pfennig, Michael Berger, Hans-Jürgen, Möller, Dittmann Sandra, Michael, Riedel, Severus Emanuel, Frangou Sophia, Seemüller, Florian, Möller Hans-Jürgen, Sandra Dittmann, Hans-Jürgen Möller   +29 more
core   +1 more source

Dietary nitrate modulates cerebral blood flow parameters and cognitive performance in humans: A double-blind, placebo-controlled, crossover investigation [PDF]

, 2015
Nitrate derived from vegetables is consumed as part of a normal diet and is reduced endogenously via nitrite to nitric oxide. It has been shown to improve endothelial function, reduce blood pressure and the oxygen cost of sub-maximal exercise, and ...
Haskell, Crystal, Winyard, Paul, Kennedy, David, Blackwell, Jamie, Blackwell, James, Thompson, Kevin, Wightman, Emma, Forster, Joanne, Jones, Andrew, Haskell-Ramsay, Crystal   +9 more
core   +1 more source

Placebo and the law of identification

Frontiers in Psychiatry
Thousands of essays and studies have been published on placebo and nocebo. Yet, despite this plethora of information, we are not much closer to a comprehensive understanding of the fundamental mechanism producing placebo and nocebo effects than we were ...
Steve F. Bierman, Andrew Weil, Stephen Dahmer   +2 more
doaj   +1 more source

Placebo response in depression

Dialogues in Clinical Neuroscience, 2002
With its naturally fluctuating course, depression is a highly placebo-responsive condition: mean placebo response rates in antidepressant clinical trials are 30% to 40%. We review the history and terminology of placebo and the proposed mechanisms underlying the placebo response, including the physician-patient relationship and biological, sociocultural,
Shamsah B, Sonawalla, Jerrold F, Rosenbaum   +1 more
openaire   +3 more sources

When Your Doctor “Gets It” and “Gets You”: The Critical Role of Competence and Warmth in the Patient–Provider Interaction

Frontiers in Psychiatry, 2019
Background: Research demonstrates that the placebo effect can influence the effectiveness of medical treatments and accounts for a significant proportion of healing in many conditions. However, providers may differ in the degree to which they consciously
Lauren C. Howe, Kari A. Leibowitz, Alia J. Crum   +2 more
doaj   +1 more source

Placebo response in migraine [PDF]

European Journal of Clinical Pharmacology, 2010
Sir I am currently in the process of revising the Guidelines for Drug Trials in Migraine of The International Headache Society. While browsing the literature for information on the placebo response in migraine randomised clinical trials (RCTs), I read with interest the extensive meta-analysis on this subject published by Macedo et al.
openaire   +3 more sources

Capitalizing on the placebo component of treatments [PDF]

, 2015
A placebo treatment is traditionally administered in a double-blind, randomized controlled trial to control for the ‘real’ effects of the treatment under investigation. In the present paper a broader view of the placebo is proposed, one in which the idea
Beedie, C., Hurst, P., Foad, A.
core   +1 more source