Results 51 to 60 of about 5,256,367 (214)

Risk of Retinopathy Associated with Long‐Term Use of Hydroxychloroquine in Patients with Rheumatic Diseases: A Systematic Review and Meta‐Analysis

Arthritis Care &Research, EarlyView.
Objective We aimed to estimate the prevalence and cumulative incidence of hydroxychloroquine retinopathy (HCQ‐R) and its risk factors among patients receiving long‐term HCQ with rheumatic diseases through a systematic review and meta‐analysis of observational studies that used spectral‐domain optical coherence tomography (SD‐OCT) for screening ...
Narsis Daftarian, Chloe Yue, Steve D Levasseur, Hui Xie, J. Antonio Avina‐Zubieta   +4 more
wiley   +1 more source

Identification of pain categories associated with change in pain in patients receiving placebo: data from two phase 3 randomized clinical trials in symptomatic knee osteoarthritis

BMC Musculoskeletal Disorders, 2018
Background Pain is the principal clinical symptom of osteoarthritis (OA), and development of safe and effective analgesics for OA pain is needed. Drug development of new analgesics for OA pain is impaired by substantial change in pain in patients ...
Asger Reinstrup Bihlet, Inger Byrjalsen, Anne-Christine Bay-Jensen, Jeppe Ragnar Andersen, Claus Christiansen, Bente Juel Riis, Ivo Valter, Morten A. Karsdal, Marc C. Hochberg   +8 more
doaj   +1 more source

Safety of Prescription Nonsteroidal Anti‐inflammatory Drugs in Adults With Inflammatory Bowel Disease: Data From a Large Administrative Claims Cohort

Arthritis Care &Research, EarlyView.
Objective The concern that nonsteroidal anti‐inflammatory drugs (NSAIDs) may precipitate flares of inflammatory bowel disease (IBD) has limited their use in managing musculoskeletal symptoms in those with IBD, but safety data are mixed. Methods This retrospective cohort study included patients with IBD aged at least 18 years from Optum's deidentified ...
Adam S. Mayer, Rui Xiao, Meenakshi Bewtra, Michael D. George, Pamela F. Weiss   +4 more
wiley   +1 more source

Developing a placebo-controlled trial in surgery: issues of design, acceptability and feasibility [PDF]

, 2011
<p>Background: Surgical placebos are controversial. This in-depth study explored the design, acceptability, and feasibility issues relevant to designing a surgical placebo-controlled trial for the evaluation of the clinical and cost effectiveness ...
Campbell, MK, McDonald, AM, Skea, Z.C, Sutherland, AG, ZC Skea, Norrie, J.D, Campbell, M.K., Cuthbertson BH, Bridgman, S., McDonald, A.M, BH Cuthbertson, AM McDonald, McDonald AM, RV Carlson, McDonald, A.M., Skea, Z.C., S Bridgman, Carlson, R V, Entwistle, V.A, Sutherland, A.G, Cuthbertson, B H, JD Norrie, Norrie, J. D., Campbell, M K, Cuthbertson, B. H., Skea, Z. C., Skea, ZC, Carlson, RV, Sutherland AG, null null, MK Campbell, Carlson, R.V., Entwistle, Vikki, McDonald, A M, Norrie, JD, Skea ZC, VA Entwistle, Carlson, R.V, Skea, Z C, AG Sutherland, Entwistle, V A, Carlson RV, Entwistle, V.A., Norrie, J D, Sutherland, A.G., Bridgman, S, Norrie, J.D., Entwistle, V. A., Sutherland, A G, Campbell, M.K, Entwistle VA, McDonald, A. M., KORAL study group, Cuthbertson, B.H., Sutherland, A. G., Cuthbertson, B.H, Campbell MK, Campbell, M. K., Entwistle, VA, Cuthbertson, BH, Bridgman S, Carlson, R. V., Norrie JD   +62 more
core   +2 more sources

Development of a Disease Activity Index for the Assessment of VEXAS Syndrome (VEXAS‐DAI)

Arthritis Care &Research, EarlyView.
Objective Vacuoles, E1 enzyme, X‐linked, autoinflammatory, somatic syndrome (VEXAS) syndrome is characterized by a complex spectrum of inflammatory and hematologic manifestations. Clinical research to identify effective therapies is urgently needed but is hindered by the lack of validated outcome measures.
Kevin Byram, Heřman Mann, Danielle Hammond, Onima Chowdhury, Sinisa Savic, Yohei Kirino, Carmelo Gurnari, Maël Heiblig, Thibault Comont, Arsène Mekinian, Mrinal M. Patnaik, Lachelle D. Weeks, Gary Ho, Adam Al‐Hakim, Scott Goldberg, Marcela A. Ferrada, Sophie Georgin‐Lavialle, Peter C. Grayson, Emma M. Groarke, Bhavisha Patel, Megan Sullivan, Sarah A. Buckley, Bryan G. Harder, Raman Garcha, David B. Beck, Matthew J. Koster   +25 more
wiley   +1 more source

The placebo effect revisited – author response

Scandinavian Journal of Work, Environment & Health, 2012
Our randomized controlled trial showed a reduction of neck/shoulder pain and headache in response to 10 weeks of resistance training performed for 2 minutes a day (1, 2).
Lars L Andersen
doaj   +1 more source

Clinical Validation of Artificial Intelligence (AI)‐based Cartilage Segmentation Predicting Knee Replacement

Arthritis Care &Research, Accepted Article.
Objective For cartilage morphology to serve as a scalable endpoint in clinical trials, analyses should be performed automatically without human interaction. To clinically validate artificial intelligence (AI)‐based analysis, we studied cartilage loss from MRI prior to knee replacement.
Felix Eckstein, David J. Hunter, C. Kent Kwoh, Wolfgang Wirth   +3 more
wiley   +1 more source

Increasing effort without noticing: A randomized controlled pilot study about the ergogenic placebo effect in endurance athletes and the role of supplement salience. [PDF]

PLoS ONE, 2018
PurposePrevious research shows that endurance performance can be enhanced by placebo ergogenic aids. This study investigates the ergogenic placebo response, which we define as an increase in objective and physiological effort without an increase in ...
Ellen K Broelz, Sebastian Wolf, Patrick Schneeweiss, Andreas M Niess, Paul Enck, Katja Weimer   +5 more
doaj   +1 more source

Capitalizing on the placebo component of treatments [PDF]

, 2015
A placebo treatment is traditionally administered in a double-blind, randomized controlled trial to control for the ‘real’ effects of the treatment under investigation. In the present paper a broader view of the placebo is proposed, one in which the idea
Beedie, C., Hurst, P., Foad, A.
core   +1 more source

Beyond Visual Scoring: Computational Computed Tomography Analysis for High‐Resolution Computed Tomography–Based Quantification of Interstitial Lung Disease in Inflammatory Rheumatic Disease

Arthritis Care &Research, EarlyView.
Interstitial lung disease (ILD) is a significant cause of morbidity and mortality in patients with inflammatory rheumatic disorders (IRDs). High‐resolution computed tomography (HRCT) is widely considered the gold standard for the noninvasive assessment of ILD; however, its interpretation is constrained by substantial interobserver variability and the ...
Alexander Pfeil, Tobias Hoffmann, Ulf Teichgräber, Diane Renz, Denise Beckmann, Gunter Wolf, Nicole Schadewaldt, Bianca Lassen‐Schmidt   +7 more
wiley   +1 more source