Results 41 to 50 of about 364,712 (294)

Twenty years after ‘Listening to Prozac but hearing placebo’. Do we hear placebo even louder?

Health Psychology Report, 2019
An active placebo is a substance that produces side effects similar to an active ingredient while not producing the same intended therapeutic effect. The aim of this study is to review the literature on the hypothesis of the active placebo response as a ...
Wojciech Oronowicz-Jaśkowiak, Przemysław Bąbel   +1 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Placebo use in the United Kingdom: results from a national survey of primary care practitioners

, 2013
Objectives: Surveys in various countries suggest 17% to 80% of doctors prescribe ‘placebos’ in routine practice, but prevalence of placebo use in UK primary care is unknown.Methods: We administered a web-based questionnaire to a representative sample of ...
Heneghan, C, Stevens, Sarah, Wolstenholme Jane, Hobbs, Richard, Stevens, S, Louhiala, Pekka, Sarah Stevens, Hemilä, Harri, Bishop, F.L, George Lewith, Hobbs F. D. Richard, Wolstenholme, Jane, Wolstenholme, J, Bishop, FL, Hobbs, F.D.R., Carl Heneghan, Stevens Sarah, Howick, Jeremy, Jeremy Howick, Lewith, George T., Felicity L Bishop, F D Richard Hobbs, Heneghan, C., Wolstenholme, J., Bishop Felicity L., Howick, J, Howick, J., Howick Jeremy, Heneghan Carl, Hobbs, FD, Lewith, G, Puustinen, Raimo, Lewith George, Jane Wolstenholme, Heneghan, Carl   +34 more
core   +1 more source

Antidepressants and the Placebo Response

Epidemiology and Psychiatric Sciences, 2009
SUMMARYAims – To evaluate new generation antidepressants in relation to the placebo response. Methods – I review meta-analyses in which response to antidepressant medication and response to placebo were calculated. Results – All but one of these meta-analyses included unpublished as well as published trials.
openaire   +2 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

AA Placebo Response Rate Supplement

, 2021
AA Placebo Response Rate ...
han, J (via Mendeley Data)
core   +1 more source

Impact of Asymptomatic Intracranial Hemorrhage on Outcome After Endovascular Stroke Treatment

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Endovascular treatment (EVT) achieves high rates of recanalization in acute large‐vessel occlusion (LVO) stroke, but functional recovery remains heterogeneous. While symptomatic intracranial hemorrhage (sICH) has been well studied, the prognostic impact of asymptomatic intracranial hemorrhage (aICH) after EVT is less certain ...
Shihai Yang, Chengsong Yue, Zhuang Li, Xiaolei Shi, Haoxuan Zhu, Jie Yang, Linyu Li, Jiaxing Song, Shitao Fan, Gaoming Li, Wenzhe Sun, Zhixian Ye, Jiacheng Huang, Dahong Yang, Jinfu Ma, Xu Xu, Zhixi Wang, Lilan Wang, Guojian Liu, Fengli Li, Changwei Guo, Li Qi, Wenjie Zi   +22 more
wiley   +1 more source

Placebo effects on the neurologic pain signature: A meta-analysis of individual participant functional magnetic resonance imaging data

, 2018
Importance Placebo effects reduce pain and contribute to clinical analgesia, but after decades of research, it remains unclear whether placebo treatments mainly affect nociceptive processes or other processes associated with pain evaluation.Objective We ...
Leknes, S., Schenk, L., Benedetti, F., Zunhammer, M., Choi, J., Büchel, C., Kaptchuk, T., Müllner-Huber, A., Wager, T., Kong, J., Wrobel, N., Ellingsen, D., Kirsch, I., Lamm, C., Lui, F., Schmid, J., Theysohn, N., Colloca, L., Tracey, I., Porro, C., Zeidan, F., Duzzi, D., Gollub, R., Kessner, S., Rütgen, M., Eippert, F. ; https://orcid.org/, Bingel, U., Elsenbruch, S., Geuter, S., Atlas, L.   +29 more
core   +1 more source

Dimethyl Fumarate, But Not Rituximab, Reduces Serum GFAP Levels and PIRMA in Relapsing–Remitting MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Serum neurofilament light chain (sNfL) and glial fibrillary acidic protein (sGFAP) levels are believed to reflect mainly acute and chronic disease processes in multiple sclerosis (MS), respectively. In this study, we investigated whether dimethyl fumarate (DMF) and rituximab (RTX) differentially affect these biomarkers.
F. Shawket, J. Lycke, J. Salzer, F. Piehl, K. Fink, N. Lange, J. Mellergård, C. Malmeström, P. Sundström, I. Erngren, A. al‐Grety, E. Freyhult, K. Kultima, J. Burman, A. Svenningsson   +14 more
wiley   +1 more source

Placebo and nocebo effects in sport [PDF]

, 2023
Placebo and nocebo effects can significantly influence sport performance. In the past two decades, research has identified various neurobiological mechanisms of its response and how an athlete’s expectation and previous experiences, can alter the ...
Hurst, P.
core