Results 1 to 10 of about 7,248 (168)

Temporal structure of brain oscillations predicts learned nocebo responses to pain [PDF]

Scientific Reports, 2021
This study aimed to identify electrophysiological correlates of nocebo-augmented pain. Nocebo hyperalgesia (i.e., increases in perceived pain resulting from negative expectations) has been found to impact how healthy and patient populations experience ...
Mia A. Thomaidou, Joseph S. Blythe, Simon J. Houtman, Dieuwke S. Veldhuijzen, Antoinette I. M. van Laarhoven, Andrea W. M. Evers   +5 more
doaj   +2 more sources

Cholecystokinin input from the anterior cingulate cortex to the lateral periaqueductal gray mediates nocebo pain behavior in mice [PDF]

Nature Communications
The nocebo effect, opposite of the better-known placebo effect, in which anticipation of harm worsens pain and other symptoms, is increasingly thought to be responsible for poor clinical outcomes.
Sandra J. Poulson, Aleksandrina Skvortsova, Fatama Tuz Zahra, Damien C. Boorman, Seyed Asaad Karimi, Lisiê V. Paz, Wanning Cui, Antonietta Mandatori, Jacob Burek, Zahra Siddiqi, Maryam I. Fazili, Shivani R. Gami, Oakley B. Morgan, Mélanie Di Maria, Anton Dinh, Lianfang Liang, Robert Contofalsky, Jeffrey S. Mogil, Loren J. Martin   +18 more
doaj   +2 more sources

Minimizing Drug Adverse Events by Informing About the Nocebo Effect—An Experimental Study

Frontiers in Psychiatry, 2019
Relevance: Informing patients about potential adverse events as part of the informed consent may facilitate the development of nocebo-driven drug adverse events (nocebo side effects).Objective: To investigate whether informing about the nocebo effect ...
Yiqi Pan, Yvonne Nestoriuc
exaly   +3 more sources

Nocebo effects are stronger and more persistent than placebo effects in healthy individuals [PDF]

eLife
Placebo and nocebo effects illustrate the profound influence of cognitive-affective processes on symptom perception and treatment outcomes, with the potential to significantly alter responses to medical interventions.
Angelika Kunkel, Katharina Schmidt, Helena Hartmann, Torben Strietzel, Jens-Lennart Sperzel, Katja Wiech, Ulrike Bingel   +6 more
doaj   +2 more sources

Risk Factors Associated With Nocebo Effects: A Review of Reviews

Brain, Behavior, & Immunity - Health
Objective: This meta-review aims to identify and categorize the risk factors that are associated with nocebo effects. The nocebo effect can exert a negative impact on treatment outcomes and have detrimental outcomes on health.
Cesare Cavalera, Francesca Grosso
exaly   +3 more sources

Placebo and nocebo in clinical practice: An online cross-sectional survey of healthcare professionals from European countries on views, practices and training needs. [PDF]

PLoS ONE
BackgroundPlacebo and nocebo effects significantly influence health outcomes, yet healthcare professionals receive limited training and guidance on their mechanisms and clinical application, creating a gap in education and practical understanding ...
Mary O'Keeffe, Nathan Skidmore, Arianna Bagnis, Przemysław Bąbel, Elżbieta A Bajcar, Alessandra De Palma, Andrea W M Evers, Eveliina Glogan, Julia W Haas, Stefanie H Meeuwis, Marek Oleszczyk, Antonio Portolés, Johan W S Vlaeyen, Katia Mattarozzi, PANACEA Consortium   +14 more
doaj   +2 more sources

A randomized pharmacological fMRI trial investigating d-cycloserine and brain plasticity mechanisms in learned pain responses

Scientific Reports, 2022
Learning and negative outcome expectations can increase pain sensitivity, a phenomenon known as nocebo hyperalgesia. Here, we examined how a targeted pharmacological manipulation of learning would impact nocebo responses and their brain correlates ...
Mia A. Thomaidou, Joseph S. Blythe, Dieuwke S. Veldhuijzen, Kaya J. Peerdeman, Johan (Hans) P. A. van Lennep, Erik J. Giltay, Henk R. Cremers, Andrea W. M. Evers   +7 more
doaj   +1 more source

How Negative Experience Influences the Brain: A Comprehensive Review of the Neurobiological Underpinnings of Nocebo Hyperalgesia

Frontiers in Neuroscience, 2021
This comprehensive review summarizes and interprets the neurobiological correlates of nocebo hyperalgesia in healthy humans. Nocebo hyperalgesia refers to increased pain sensitivity resulting from negative experiences and is thought to be an important ...
Mia A. Thomaidou, Mia A. Thomaidou, Kaya J. Peerdeman, Kaya J. Peerdeman, Melissa I. Koppeschaar, Andrea W. M. Evers, Andrea W. M. Evers, Andrea W. M. Evers, Andrea W. M. Evers, Dieuwke S. Veldhuijzen, Dieuwke S. Veldhuijzen   +10 more
doaj   +1 more source

No evidence that attentional bias towards pain-related words is associated with verbally induced nocebo hyperalgesia: a dot-probe study

PAIN Reports, 2021
. Introduction:. Placebo and nocebo effects in pain are well documented. One leading explanation is that instructions indicating that pain will either increase or decrease after receipt of a treatment give rise to expectations for increased or decreased ...
Matthew James Coleshill, Louise Sharpe, Ben Colagiuri   +2 more
doaj   +1 more source

Counterconditioning as Treatment to Reduce Nocebo Effects in Persistent Physical Symptoms: Treatment Protocol and Study Design

Frontiers in Psychology, 2022
Persistent physical symptoms have a high prevalence and a large impact for patients and society. To date, treatment effects for these symptoms are often limited.
Simone Meijer, Simone Meijer, Henriët van Middendorp, Henriët van Middendorp, Kaya J. Peerdeman, Kaya J. Peerdeman, Andrea W. M. Evers, Andrea W. M. Evers, Andrea W. M. Evers, Andrea W. M. Evers   +9 more
doaj   +1 more source