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Nocebo effects are stronger and more persistent than placebo effects in healthy individuals [PDF]
eLifePlacebo and nocebo effects illustrate the profound influence of cognitive-affective processes on symptom perception and treatment outcomes, with the potential to significantly alter responses to medical interventions.
Angelika Kunkel +6 more
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Pharmacology Research and Perspectives, 2016 AbstractWhile the placebo effect has been studied for a long time, much less is known about its negative counterpart, named the nocebo effect. However, it may be of particular importance because of its impact on the treatment outcomes and public health. We conducted a review on the nocebo effect using PubMed and other databases up to July 2014.
Planès, Sara +2 more
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Implications of nocebo in anaesthesia care [PDF]
Anaesthesia, 2022 Summary Nocebo refers to non‐pharmacological adverse effects of an intervention. Well‐intended procedural warnings frequently function as a nocebo. Both nocebo and placebo are integral to the generation of ‘real’ treatment effects and their associated ‘real’ side‐effects.
Allan Cyna, Laura Burgoyne
exaly +3 more sources
Placebo and nocebo in clinical practice: An online cross-sectional survey of healthcare professionals from European countries on views, practices and training needs. [PDF]
PLoS ONEBackgroundPlacebo and nocebo effects significantly influence health outcomes, yet healthcare professionals receive limited training and guidance on their mechanisms and clinical application, creating a gap in education and practical understanding ...
Mary O'Keeffe +14 more
doaj +2 more sources
A systematic review of sex differences in the placebo and the nocebo effect
Journal of Pain Research, 2017 Sara M Vambheim,1 Magne Arve Flaten2 1Department of Psychology, UiT, The Arctic University of Norway, Tromsø, 2Department of Psychology, Norwegian University of Science and Technology (NTNU), Trondheim, Norway Objectives: The present review ...
Magne Arve Flaten +1 more
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Risk factors associated with nocebo effects: A review of reviews
Brain, Behavior, & Immunity - HealthObjective: This meta-review aims to identify and categorize the risk factors that are associated with nocebo effects. The nocebo effect can exert a negative impact on treatment outcomes and have detrimental outcomes on health.
Cesare Cavalera +2 more
exaly +3 more sources
Temporal structure of brain oscillations predicts learned nocebo responses to pain
Scientific Reports, 2021 This study aimed to identify electrophysiological correlates of nocebo-augmented pain. Nocebo hyperalgesia (i.e., increases in perceived pain resulting from negative expectations) has been found to impact how healthy and patient populations experience ...
Mia A. Thomaidou +5 more
doaj +1 more source
Scientific Reports, 2022 Learning and negative outcome expectations can increase pain sensitivity, a phenomenon known as nocebo hyperalgesia. Here, we examined how a targeted pharmacological manipulation of learning would impact nocebo responses and their brain correlates ...
Mia A. Thomaidou +7 more
doaj +1 more source
Frontiers in Neuroscience, 2021 This comprehensive review summarizes and interprets the neurobiological correlates of nocebo hyperalgesia in healthy humans. Nocebo hyperalgesia refers to increased pain sensitivity resulting from negative experiences and is thought to be an important ...
Mia A. Thomaidou +10 more
doaj +1 more source
PAIN Reports, 2021 . Introduction:. Placebo and nocebo effects in pain are well documented. One leading explanation is that instructions indicating that pain will either increase or decrease after receipt of a treatment give rise to expectations for increased or decreased ...
Matthew James Coleshill +2 more
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