Nocebo response intensity and influencing factors in the randomized clinical trials of irritable bowel syndrome: A systematic review and meta-analysis [PDF]
Frontiers in Medicine, 2022 ObjectiveTo estimate the magnitude of the nocebo response and explore its influencing factors in irritable bowel syndrome (IBS).MethodsThe PubMed, Embase, and Cochrane Library databases were searched up to March 2021.
Ruijie Li +9 more
doaj +4 more sources
Trait responsiveness to verbal suggestions predicts nocebo responding: A meta-analysis. [PDF]
Br J Health Psychol, 2023 AbstractNocebo responding involves the experience of adverse health outcomes in response to contextual cues. These deleterious responses impact numerous features of mental and physical health but are characterized by pronounced heterogeneity. Suggestion is widely recognised as a contributing factor to nocebo responding but the moderating role of trait ...
Stein MV +4 more
europepmc +4 more sources
Nocebo hyperalgesia and the startle response [PDF]
Neuroscience, 2016 The literature on the effects of nocebo on pain is sparse. The present experimental study investigated whether suggestions of nocebo hyperalgesia modified the startle response and whether increased startle contributed to the nocebo hyperalgesic effect.A design with four groups was employed; the participants were randomized into either a placebo group ...
Aslaksen, Per M. +3 more
openaire +5 more sources
The Placebo and Nocebo Responses in Clinical Trials in Inflammatory Bowel Diseases [PDF]
Frontiers in Pharmacology, 2021 Placebo and nocebo responses are mostly discussed in clinical trials with functional bowel disorders. Much less has been investigated and is known in gastrointestinal diseases beyond irritable bowel syndrome (IBS), especially in inflammatory bowel ...
Paul Enck, Sibylle Klosterhalfen
doaj +3 more sources
Can Nocebo Effects Be Reduced via Open- and Closed-Label Counterconditioning? [PDF]
Eur J PainABSTRACT Background The overwhelming evidence of nocebo effects adversely affecting the experience of physical symptoms, such as pain, puts emphasis on the study of possible strategies to reduce nocebo effects. Counterconditioning, during which a previously conditioned effect is reversed, has been shown to be a possible promising strategy in a previous
Meijer S +3 more
europepmc +2 more sources
New Insights into the Placebo and Nocebo Responses [PDF]
Neuron, 2008 In modern medicine, the placebo response or placebo effect has often been regarded as a nuisance in basic research and particularly in clinical research. The latest scientific evidence has demonstrated, however, that the placebo effect and the nocebo effect, the negative effects of placebo, stem from highly active processes in the brain that are ...
Enck P +2 more
openaire +5 more sources
Bad Is More Powerful than Good: The Nocebo Response in Medical Consultations [PDF]
The American Journal of Medicine, 2015 Although there has been a lot of research looking at the placebo response, nocebo responses in the healthcare setting have been largely overlooked. This article explores the potential role of negative patient-doctor communication in facilitating nocebo responses in the medical consultation. We suggest that invalidation, that is, communicating a lack of
Greville-Harris, M.L., Dieppe, P.
openaire +6 more sources
Effect of enhanced support for coping with side effects during medication counselling on the nocebo effect in patients with advanced lung cancer receiving initial chemotherapy: protocol for a multicentre exploratory open-label randomised controlled trial [PDF]
BMJ OpenIntroduction Chemotherapy-induced nausea and vomiting (CINV) is a common symptom in cancer, and it is one of the distressing symptoms in patients with cancer receiving chemotherapy.
Yoshinobu Matsuda +6 more
doaj +2 more sources
The High-Risk Model of Threat Perception Modulates Learning of Placebo and Nocebo Effects and Functional Somatic Disorders [PDF]
Brain SciencesThreat activation or deactivation in the brain–body is associated with learned nocebo or placebo somatic effects induced by fake invasive medical–surgical procedures.
Ian Wickramasekera
doaj +2 more sources
Factors Associated With Self-Medication to Mitigate Vaccine Reactions After COVID-19 Vaccination: A Prospective Cohort Study. [PDF]
Pharmacoepidemiol Drug SafABSTRACT Objective Management of vaccine reactions with analgesics/antipyretics can enhance acceptance and adherence to future vaccinations. However, inappropriate self‐medication may pose health risks, particularly for individuals with chronic conditions.
Blattner M +5 more
europepmc +2 more sources