Results 51 to 60 of about 4,003 (171)

Peripheral Inflammation and Sleep Loss Induce Coordinated Motivational Changes: An Experimental Two‐Hit Stress Model

open access: yesJournal of Sleep Research, EarlyView.
ABSTRACT Sleep loss and low‐grade inflammation are common stressors that affect behaviour and recovery needs. To examine their separate and combined effects on motivation for everyday behaviours, we developed a two‐hit experimental model. Participants (N = 56, 31 women) completed three experimental visits: sleep saturation (two nights, 9 h in bed/night)
John Axelsson   +6 more
wiley   +1 more source

Placebo Analgesia, Nocebo Hyperalgesia, and the Cardiovascular System: A Qualitative Systematic Review

open access: yesFrontiers in Physiology, 2020
Background: Placebo/nocebo effects involve the autonomic nervous system, including cardiac activity, but studies have reported inconsistent findings on how cardiac activity is modulated following a placebo/nocebo effect. However, no systematic review has
Hojjat Daniali, Magne Arve Flaten
doaj   +1 more source

Ischaemic pre‐conditioning improves workload, fatigue and recovery in team sport: A randomized, double‐blind, placebo‐controlled crossover trial

open access: yesExperimental Physiology, EarlyView.
Abstract Ischaemic preconditioning (IPC) is reported to improve performance, fatigue and recovery, yet evidence in team‐sport settings remains limited. We examined the effects of repeated IPC on external workload, perceptual strain and recovery during ecologically valid Gaelic football training.
Lorcan Daly   +2 more
wiley   +1 more source

Nocebo and pain: an overview of the psychoneurobiological mechanisms

open access: yesPAIN Reports, 2017
. Introduction:. Nocebo effects are defined as adverse events related to negative expectations and learning processes that are involved in the modulation of the descending pain pathways.
Maxie Blasini   +3 more
doaj   +1 more source

Differential Impact of Pharmacokinetic and Pharmacodynamic Variability on Response to Combination Therapy

open access: yesPharmacology Research &Perspectives, Volume 14, Issue 4, August 2026.
ABSTRACT Interindividual variability (IIV) in drug response complicates both fixed‐dose design and individualized therapy. Understanding how pharmacokinetic (PK) and pharmacodynamic (PD) processes jointly shape this variability is essential, particularly in combination therapy, where multiple interacting pathways influence outcomes. This study employed
Kuteesa R. Bisaso   +3 more
wiley   +1 more source

Financial Toxicity Associated with Biological Medicines: A Scoping Review

open access: yesClinical Pharmacology &Therapeutics, Volume 120, Issue 1, Page 81-93, July 2026.
Financial toxicity, defined as the economic burden experienced by patients due to medication and other healthcare costs and their consequences, such as material, psychosocial and behavioral effects, represents a significant concern for individuals receiving biological medicines.
Laura Sara Maria Saarukka   +4 more
wiley   +1 more source

Unraveling Inflammatory Pain: A Narrative Review of Molecular Pathways and Multidisciplinary Treatments

open access: yesHealth Science Reports, Volume 9, Issue 6, June 2026.
ABSTRACT Background Inflammatory pain is a widespread global health concern arising from complex molecular pathways triggered by a consequence of tissue damage and immune activation. It significantly impacts quality of life and functional outcomes, necessitating a comprehensive understanding of underlying mechanisms and multidisciplinary approaches for
Fatma Mohamed Elmansy   +6 more
wiley   +1 more source

Nocebo Effect in patients with Adverse Drug Reactions: The Role of Emotion Regulation

open access: yesMediterranean Journal of Clinical Psychology, 2019
Patients who have experienced adverse drug reactions (ADRs) can show some psychological problems both pre-existing than consequently the reactions.
Mara Donatella Fiaschi   +3 more
doaj   +1 more source

Diagnostic Features of Discogenic Low Back Pain: A Narrative Review and Suggested Areas for Future Research and Clinical Practice

open access: yesJOR SPINE, Volume 9, Issue 2, June 2026.
ABSTRACT Background Chronic low back pain is a leading cause of global disability, with discogenic low back pain (DLBP), mechanically stimulated pain arising from the intervertebral disc, representing an important but often under‐recognized subtype. DLBP arises from chronic structural and metabolic changes within the intervertebral disc, leading to ...
William Roger Peters   +2 more
wiley   +1 more source

Placebo and nocebo effects in the neurological practice

open access: yesArquivos de Neuro-Psiquiatria, 2015
Knowledge of placebo and nocebo effects is essential to identify their influence on the results in clinical practice and clinical trials, and thereby properly interpret their results.
Caroline Bittar, Osvaldo J.M. Nascimento
doaj   +1 more source

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