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Animal Models of Nociception [PDF]
Pharmacological Reviews, 2001 The study of pain in awake animals raises ethical, philosophical, and technical problems. We review the ethical standards for studying pain in animals and emphasize that there are scientific as well as moral reasons for keeping to them. Philosophically, there is the problem that pain cannot be monitored directly in animals but can only be estimated by ...
Le Bars, Daniel +2 more
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Cortical Modulation of Nociception
Neuroscience, 2021Nociception is the neuronal process of encoding noxious stimuli and could be modulated at peripheral, spinal, brainstem, and cortical levels. At cortical levels, several areas including the anterior cingulate cortex (ACC), prefrontal cortex (PFC), ventrolateral orbital cortex (VLO), insular cortex (IC), motor cortex (MC), and somatosensory cortices are
Abimael González-Hernández +3 more
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Molecular mechanisms of nociception
Nature, 2001The sensation of pain alerts us to real or impending injury and triggers appropriate protective responses. Unfortunately, pain often outlives its usefulness as a warning system and instead becomes chronic and debilitating. This transition to a chronic phase involves changes within the spinal cord and brain, but there is also remarkable modulation where
Allan I. Basbaum, David Julius
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Revue Neurologique, 2021
Understanding intracranial nociceptive innervation is essential to understand the pathophysiology of headaches. Our knowledge about human intracranial nociception comes from sparse observations during neurosurgical procedures performed in awake patients, from human anatomical studies and from experimental studies in animals.
L.-M. Terrier, D. Fontaine
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Understanding intracranial nociceptive innervation is essential to understand the pathophysiology of headaches. Our knowledge about human intracranial nociception comes from sparse observations during neurosurgical procedures performed in awake patients, from human anatomical studies and from experimental studies in animals.
L.-M. Terrier, D. Fontaine
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Photoplethysmography and nociception
Acta Anaesthesiologica Scandinavica, 2009Photoplethysmography (PPG), i.e. pulse oximetric wave, is a non‐invasive technique that is used in anaesthesia monitoring primarily to monitor blood oxygenation. The PPG waveform resembles that of the arterial blood pressure but instead of pressure it is related to the volume changes in the measurement site and hence contains information related to the
Arvi Yli-Hankala, Ilkka Korhonen
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Monitoring the nociception–anti-nociception balance
Best Practice & Research Clinical Anaesthesiology, 2013At present, short-acting drugs are used in order to achieve the three components of anaesthesia, that is, analgesia, hypnosis and immobility. Assessment of the 'analgesia' component in daily clinical routine is, in contrast to the other components, still based on very unspecific clinical 'end' points such as movement, tearing, tachycardia or ...
Matthias Gruenewald, C. Ilies
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Current Opinion in Neurobiology, 1991
In recent years, progress in the treatment of pain has been strongly influenced by new insights into the mechanisms underlying pain and nociception. The following article briefly reviews some recent reports which make a significant contribution to our knowledge of the structure and function of nocisensors, the neuropeptides involved in the nociceptive ...
Bernd Heppelmann +3 more
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In recent years, progress in the treatment of pain has been strongly influenced by new insights into the mechanisms underlying pain and nociception. The following article briefly reviews some recent reports which make a significant contribution to our knowledge of the structure and function of nocisensors, the neuropeptides involved in the nociceptive ...
Bernd Heppelmann +3 more
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Advanced Materials, 2018
AbstractThe biomimetic characteristics of the memristor as an electronic synapse and neuron have inspired the advent of new information technology in the neuromorphic computing. The application of the memristors can be extended to the artificial nerves on condition of the presence of electronic receptors which can transfer the external stimuli to the ...
Yumin Kim +10 more
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AbstractThe biomimetic characteristics of the memristor as an electronic synapse and neuron have inspired the advent of new information technology in the neuromorphic computing. The application of the memristors can be extended to the artificial nerves on condition of the presence of electronic receptors which can transfer the external stimuli to the ...
Yumin Kim +10 more
openaire +2 more sources
Depth of Anesthesia and Nociception Monitoring: Current State and Vision For 2050.
Anesthesia and AnalgesiaAnesthesia objectives have evolved into combining hypnosis, amnesia, analgesia, paralysis, and suppression of the sympathetic autonomic nervous system. Technological improvements have led to new monitoring strategies, aimed at translating a qualitative ...
Pascal Laferrière-Langlois +5 more
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1984
Publisher Summary This chapter describes the algesic peptides, opioid peptides, naloxone-sensitive nonopioid peptides, naloxone-insensitive peptides, and peptides with mixed effects. The chapter presents certain criteria that need to be fulfilled to demonstrate the involvement of an endogenous peptide in nociception.
Daniel E. Hernandez +3 more
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Publisher Summary This chapter describes the algesic peptides, opioid peptides, naloxone-sensitive nonopioid peptides, naloxone-insensitive peptides, and peptides with mixed effects. The chapter presents certain criteria that need to be fulfilled to demonstrate the involvement of an endogenous peptide in nociception.
Daniel E. Hernandez +3 more
openaire +2 more sources