Results 241 to 250 of about 87,919 (361)

Efficacy and safety of a selective partial agonist for nociception/orphanin‐FQ peptide (NOP) receptors in patients with insomnia disorder

open access: yesBritish Journal of Clinical Pharmacology, Volume 92, Issue 1, Page 172-185, January 2026.
Aims Insomnia is a common sleep disorder, affecting up to 20% of the world population and adversely impacting productivity, health, and overall well‐being. Although pharmacologic options exist to treat insomnia, the health‐related quality of life for patients who are prescribed hypnotics is no higher than for those who are not, revealing a significant ...
Garth T. Whiteside   +5 more
wiley   +1 more source

Gangliosides and nociception

open access: yesFolia Pharmacologica Japonica, 2015
Shun, Watanabe, Mitsuo, Tanabe
openaire   +3 more sources

Effects of Aging on Pain Tolerance: A Comparative Study of Heat Pain Thresholds and Tonic Heat and Cold Stimuli

open access: yesEuropean Journal of Pain, Volume 30, Issue 1, January 2026.
ABSTRACT Introduction Aging is known to impact both pain perception and modulation. While sensory thresholds have been extensively studied, age‐related changes in pain tolerance remain less conclusive. Additionally, limited research has explored whether thermal modality differentially affects pain tolerance in older adults.
Julia Devanne, Louise Trocmet
wiley   +1 more source

Nociception-specific blink reflex: pharmacology in healthy volunteers [PDF]

open access: gold, 2015
Juana Marin   +4 more
openalex   +1 more source

Reliable Biomarkers of Descending Pain Inhibition: A Laser‐Evoked Potential and Behavioural Study

open access: yesEuropean Journal of Pain, Volume 30, Issue 1, January 2026.
ABSTRACT Background Conditioned pain modulation (CPM) assesses descending pain inhibition, but behavioural approaches are limited by subjectivity and variable reproducibility. We tested a CPM protocol combining nociceptive‐selective laser‐evoked potentials (LEPs) with a repeated‐trial design to determine whether neurophysiological markers complement ...
Dan Wang   +8 more
wiley   +1 more source

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