Results 271 to 280 of about 87,919 (361)

Quercetin Alleviates Osteoarthritis Pain by Inhibiting Vascular Endothelial Growth Factor A Through Regulating cGAS/STING Pathway

Journal of Cellular and Molecular Medicine, Volume 30, Issue 1, January 2026.
ABSTRACT Knee osteoarthritis (KOA), a common degenerative joint disease marked by pain, inflammation and cartilage degradation, has been increasingly associated with dysregulated innate immune signalling. Among the implicated molecular pathways, cGAS/STING has emerged as a key modulator in both disease pathogenesis and therapeutic intervention ...
Enrui Hu, Yibao Wei, Taiyang Liao, Deren Liu, Zijian Gong, Jun Mao, Peimin Wang, Nongshan Zhang   +7 more
wiley   +1 more source

Pharmacokinetics and pharmacodynamics of cannabigerol (CBG) in the C57BL/6Crl mouse. [PDF]

Front Pharmacol
Zagzoog A, Halter K, Ha N, Jones AM, Andres R, Kim A, Michel D, Alcorn J, Laprairie RB.   +8 more
europepmc   +1 more source

Comparisons of electroencephalographically derived measures of hypnosis and antinociception during propofol-remifentanil anesthesia [PDF]

, 2015
Absalom, Anthony R, Kalmar, Alain, Liley, DTJ, Sahinovic, Marco M, Shoushtarian, M, Struys, Michel, VEREECKE, HUGO   +6 more
core  

Tuina Inhibits Synaptic Plasticity Through the Astrocytic NDRG2/GLT‐1 Pathway to Alleviate Neuropathic Pain

Journal of Cellular and Molecular Medicine, Volume 30, Issue 1, January 2026.
ABSTRACT While Tuina has demonstrated clinical efficacy in alleviating neuropathic pain (NP) induced by peripheral nerve injury, the underlying molecular mechanisms remain unclear. Synaptic plasticity in the spinal dorsal horn (SDH) is a key regulator of pain processing, wherein astrocytes play a central role.
Huanzhen Zhang, Lechun Chen, Jingjing Jiang, Limei Huang, Hongye Huang, Lanting Huang, Shuijin Chen, Zhigang Lin   +7 more
wiley   +1 more source

Neurexin regulates mechanical nociceptive sensitization by central inhibition in <i>Drosophila</i>. [PDF]

Sci Adv
Meng Z, Geng J, Sun Y, Xu L, Zhao Y, Ou M, Wang Y, Han J, Gu P, Xie W.   +9 more
europepmc   +1 more source

The Functional Anatomy of Nociception: Effective Connectivity in Chronic Pain and Placebo Response

Sanjeev Nara, Marwan N. Baliki, Karl Friston, Dipanjan Ray   +3 more
openalex   +2 more sources

A Review of the Mechanisms of Action of the Herbal Medicine, STW 5‐II, Underlying Its Efficacy in Disorders of Gut–Brain Interaction

Neurogastroenterology &Motility, Volume 38, Issue 1, January 2026.
The pathophysiology of functional dyspepsia and irritable bowel syndrome includes altered motility, secretion, sensitivity to sensory signals, impaired epithelial barrier function, inflammation, and gut dysbiosis. The phytomedicine, STW 5‐II, represents a multi‐targeted approach, addressing these pathophysiologies.
Anita Annaházi, Rudolf Bauer, Thomas Efferth, Mohamed T. Khayyal, Michael Schemann, Gudrun Ulrich‐Merzenich, Christine Feinle‐Bisset   +6 more
wiley   +1 more source

Alcohol use disorder-associated pain: clinical and preclinical evidence. [PDF]

Alcohol
Dong Y, Buczynski MW, Gregus AM.
europepmc   +1 more source

TRPA1 Contributes to Cold, Mechanical, and Chemical Nociception but Is Not Essential for Hair-Cell Transduction

Neuron, 2006
Kelvin Y. Kwan, A. Allchorne, Melissa A. Vollrath, Adam P. Christensen, Duan-Sun Zhang, C. Woolf, D. Corey   +6 more
semanticscholar   +1 more source

The Implementation of Persistent Spinal Pain Syndrome (PSPS): Mechanism‐Based Recommendations

Pain Practice, Volume 26, Issue 1, January 2026.
ABSTRACT Background In 2021, the term persistent spinal pain syndrome (PSPS) was introduced. PSPS type 2 (PSPS‐T2) replaced the unsatisfactory term failed back surgery syndrome (FBSS). PSPS type 1 (PSPS‐T1) is a clinical picture of signs and symptoms of FBSS but without prior surgery. PSPS applies to any spinal level.
Simon Thomson, Brian Simpson, Frank J. Huygen, Michael Stanton‐Hicks, Richard B. North, Giancarlo Barolat, Harriet Scott, Rui V. Duarte   +7 more
wiley   +1 more source