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Neurotrophins, nociceptors, and pain
Microscopy Research and Technique, 1999It is now well established that neurotrophins play a crucial role in the development of the nervous system. However, there is increasing evidence that the function of neurotrophins persists throughout adulthood. The broad scope of neurotrophin action is well documented in the case of nerve growth factor (NGF) and its effect on nociceptors and ...
L M, Mendell, K M, Albers, B M, Davis
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Neurotrophins, nociceptors and pain
Current Opinion in Anaesthesiology, 2000Nerve growth factor (NGF) is known to play a key role in the development of hyperalgesia after inflammatory injury. The increased levels of NGF that accompany injury lead to hyperalgesia via peripheral and central spinal mechanisms. New evidence reviewed here indicates that NGF can directly sensitize nociceptive neurones to noxious heat stimuli through
P A, Heppenstall, G R, Lewin
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Nociceptor activation and pain
Philosophical Transactions of the Royal Society of London. B, Biological Sciences, 1985Abstract This paper reviews advances in our knowledge on the physiological properties of human nociceptors and their capacity to signal pain. Conventional microneurography was used in combination with intraneural microstimulation in subjects who estimated the magnitude of pain from nociceptor stimulation.
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Nociceptor plasticity: A closer look
Journal of Cellular Physiology, 2017Nociceptors are receptors specifically involved in detecting a tissue damage and transducing it in an electrical signal. Nociceptor activation provoked by any kind of acute lesion is related to the release of several mediators of inflammation, within the framework of a process defined as “peripheral sensitization.” This results in an exaggerated ...
PACE, Maria Caterina +10 more
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Nociceptors of the Joint with Particular Reference to Silent Nociceptors
2007This chapter summarizes recent research on mechanisms by which diseased joints become painful. Joints are supplied with sensory AΒ, Aδ and C fibers.
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Nociceptors: Their Role in Body’s Defenses, Tissue Specific Variations and Anatomical Update
Journal of Pain Research, 2022Vladimir Nikolenko +2 more
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Gut-innervating nociceptors regulate the intestinal microbiota to promote tissue protection
Cell, 2022Hiroshi Yano, Mengze Lyu, Wen Zhang
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