Results 111 to 120 of about 206,767 (279)

Single‐Cell Dissection of Tumor‐Infiltrating Lymphocytes Reveals Cellular Architecture Predictive of Therapeutic Efficacy in Acral Melanoma

Advanced Science, EarlyView.
Autologous tumor‐infiltrating lymphocyte (TIL) therapy shows promising efficacy in acral melanoma, yet determinants of durable response remain unclear. By integrating single‐cell transcriptomics and TCR sequencing, this study reveals that TIL products enriched for T follicular helper and intermediate exhausted T cells establish persistent clonal ...
Chao Zhang, Wanyi Xiao, Hongru Shen, Fenge Li, Ting Li, Weihong Zhang, Haotian Liu, Ziwei Gao, Hongyu Wang, Xiubao Ren, Kexin Chen, Xiangchun Li, Jilong Yang   +12 more
wiley   +1 more source

Room‐Temperature Magnetic Skyrmions and Intrinsic Anomalous Hall Effect in a Nodal‐Line Kagomé Ferromagnet MnRhP

Advanced Science, EarlyView.
MnRhP has been identified as a novel kagomé magnet that hosts magnetic skyrmions above room temperature and exhibits a large intrinsic anomalous Hall effect. The latter originates from Berry curvature associated with gapped nodal lines, establishing MnRhP as a promising platform for exploring high‐temperature topological phenomena in both real and ...
Kosuke Karube, Ming‐Chun Jiang, Lukas Keller, Jonathan S. White, Yi Ling Chiew, Xiuzhen Yu, Guang Yu Guo, Ryotaro Arita, Yoshinori Tokura, Yasujiro Taguchi   +9 more
wiley   +1 more source

A Janus‐Like Bio‐Inspired Strategy for 3D‐Printed Bimetallic Metamaterials with Excellent Thermal‐Protection and Load Bearing Capacity

Advanced Science, EarlyView.
A Janus‐like bio‐inspired strategy is proposed for integrally 3D‐printed bimetallic metamaterials. Inspired by shell bilayers, a heat‐resistant AlSiFeMnNiMg alloy and a SiC‐reinforced AlSi10Mg with different SiC volume fractions are arranged as an architected pair.
Zhicheng Dong, Wei Cheng, Yu He, Ben Jia, Xiaopeng Wan, Heyuan Huang   +5 more
wiley   +1 more source

Semi-Dirac Fermions in a Topological Metal

Physical Review X
Topological semimetals with massless Dirac and Weyl fermions represent the forefront of quantum materials research. In two dimensions, a peculiar class of fermions that are massless in one direction and massive in the perpendicular direction was ...
Yinming Shao, Seongphill Moon, A. N. Rudenko, Jie Wang, Jonah Herzog-Arbeitman, Mykhaylo Ozerov, David Graf, Zhiyuan Sun, Raquel Queiroz, Seng Huat Lee, Yanglin Zhu, Zhiqiang Mao, M. I. Katsnelson, B. Andrei Bernevig, Dmitry Smirnov, Andrew J. Millis, D. N. Basov   +16 more
doaj   +1 more source

Dual‐Strategy Design of Heterojunction‐Enhanced Piezoelectric Hydrogels for Periodontitis Treatment

Advanced Science, EarlyView.
This study developed a piezoelectric hydrogel integrating heterojunction enhancement and dual‐salt synergy, combining robust electrical performance with mechanical stability and bioactivity to better match the periodontal microenvironment. Under ultrasound activation, the hydrogel markedly promotes macrophage M2 polarization, thereby reducing the ...
Qiangqiang Zhou, Shaojun Fang, Changyi Li, Mengqi Zhou, Xin Sui, Chen Hu, Huaxing Xu, Shiyi Yang, Bing‐Qiang Lu, Rongjun Zhang, Xiaoling Wei   +10 more
wiley   +1 more source

Pressure‐Induced Structural and Magnetic Evolution in Layered Antiferromagnet YbMn2Sb2

Advanced Electronic Materials, EarlyView.
Pressure tunes the delicate balance between structure, magnetism, and electronic states in quantum materials. In YbMn2Sb2, high‐pressure X‐ray and neutron diffraction reveal a trigonal‐to‐monoclinic transition near 3.5 GPa, accompanied by unconventional magnetic ordering.
Mingyu Xu, Matt Boswell, Aya Rutherford, Cheng Peng, Ying Zhou, Shuyang Wang, Zhaorong Yang, Antonio M. dos Santos, Haidong Zhou, Weiwei Xie   +9 more
wiley   +1 more source

Conversion Therapy for cT4b and M1 Esophageal Squamous Cell Carcinoma: A Comprehensive Systematic Review

Annals of Gastroenterological Surgery, EarlyView.
We systematically reviewed conversion therapy for esophageal squamous cell carcinoma and propose a response‐based treatment strategy for cT4b and M1 disease. For cT4b, we emphasize definitive chemoradiotherapy with timed re‐evaluation and selective salvage or chemoselection to surgery; for M1, conversion is reserved for limited‐burden responders with ...
Eisuke Booka, Hiroya Takeuchi
wiley   +1 more source

European guidelines from the EHTG and ESCP for Lynch syndrome: an updated third edition of the Mallorca guidelines based on gene and gender

BJS (British Journal of Surgery), EarlyView., 2020
Recommendations for clinical and molecular identification of LS, surgical and endoscopic management of LS‐associated colorectal cancer and preventive measures for cancer were produced. The emphasis was on surgical and gastroenterological aspects of the cancer spectrum.
T. T. Seppälä, A. Latchford, I. Negoi, A. Sampaio Soares, R. Jimenez‐Rodriguez, L. Sánchez‐Guillén, D. G. Evans, N. Ryan, E. J. Crosbie, M. Dominguez‐Valentin, J. Burn, M. Kloor, M. von Knebel Doeberitz, F. J. B. van Duijnhoven, P. Quirke, J. R. Sampson, P. Møller, G. Möslein, on behalf of the European Hereditary Tumour Group (EHTG) and European Society of Coloproctology (ESCP)   +18 more
wiley   +1 more source

Laparoscopic and Endoscopic Cooperative Surgery for Gastric Cancer as an Alternative Treatment in Elderly Patients: A Prospective Observational Study

Annals of Gastroenterological Surgery, EarlyView.
In a prospective study of 20 elderly gastric cancer patients who declined gastrectomy, laparoscopic and endoscopic cooperative surgery (LECS) was technically safe and preserved postoperative function. However, as oncological curability cannot be assured in advanced cases, careful selection and informed consent are essential.
Marie Washio, Keishi Yamashita, Takuya Wada, Mikiko Sakuraya, Hiroki Harada, Tadashi Higuchi, Koshi Kumagai, Yasushi Orihashi, Chika Kusano, Naoki Hiki   +9 more
wiley   +1 more source

Long‐term prognosis is associated with residual disease after neoadjuvant systemic therapy but not with initial nodal status

BJS (British Journal of Surgery), EarlyView., 2020
This long‐term follow‐up study determined survival rates in a Swedish national cohort of 417 patients with breast cancer who all had neoadjuvant systemic therapy (NAST). Sentinel lymph node biopsy (SLNB) was performed before NAST in clinically node‐negative and after NAST in clinically node‐positive patients.
L. Zetterlund, F. Celebioglu, T. Hatschek, J. Frisell, J. de Boniface   +4 more
wiley   +1 more source