Results 121 to 130 of about 219,811 (315)
Advanced Science, EarlyView.An m6A‐modified circRNA, circPSMB1, is identified as a tumor suppressor in chordoma. METTL3‐dependent m6A promotes circPSMB1 interaction with HNRNPA2B1, limiting c‐MYC expression and malignant progression. An injectable HMnO2‐based nanohydrogel enables local circPSMB1 delivery and tumor microenvironment‐responsive therapy, offering a promising strategy
Yingchuang Tang +7 more
wiley +1 more source
Viruses of Nitrogen-Fixing Mesorhizobium Bacteria in Globally Distributed Chickpea Root Nodules
Phytobiomes JournalLegume nodules are specialized environments on plant roots that are induced and dominated by nitrogen-fixing bacteria. Bacteriophages (phages) in these nodules could potentially provide top-down controls on the population size and, therefore, the ...
Brandon L. Matsumoto +7 more
doaj +1 more source
Advanced Science, EarlyView.Tumor‐associated inflammation retains antibody‐targeted or non‐specific antibody conjugated nanoparticles within the tumor microenvironment. Magnetic Particle Imaging (MPI) enables non‐invasive detection and differentiation of tumors from other organs, owing to higher nanoparticle retention by inflammatory cells in the tumor periphery.
Preethi Korangath +9 more
wiley +1 more source
An unusual presentation revealing pancreatic carcinoma: Sister Mary Joseph Nodule
, 2019 Sister Mary Joseph Nodule (SMJN) is a cutaneous nodule resulting from metastasis of malignant tumors affecting the umbilicus; it had been reported in 0.7e10.4% of patients.This case report describes an 82-year-old male diagnosed with metastatic ...
Zouhour Samlani +10 more
core +1 more source
Advanced Science, EarlyView.BNC2 exhibits context‐dependent opposing functions across multiple cancer types. This study reveals BNC2 as an oncogenic driver of melanoma proliferation and metastasis through transcriptional activation of PIK3CA. The natural compound TSN simultaneously degrades BNC2 and its oncogenic partner SMAD3 via CRBN‐dependent ubiquitination.
Hui Dai +7 more
wiley +1 more source
FNAC of cutaneous metastatic nodules; a clinicopathologic study with review of literature [PDF]
Al Ameen Journal of Medical Sciences, 2013 Background: Cutaneous metastasis (CM) from an underlying carcinoma is not an uncommon event. The incidence epidemiology and prognosis of these patients is poorly known.
Suprio Ray Chaudhury +4 more
doaj
Advanced Science, EarlyView.AARS1 drives PI3K–AKT–mTOR‐dependent glycolysis in bladder cancer, promoting lactate accumulation, increased lactylation, H3K27la enrichment at the HK2 promoter, and HK2 transcription. HK2 reinforces glycolysis, sustaining a metabolic–epigenetic program associated with tumor progression, recurrence, and metastasis.
Qin Yuan +13 more
wiley +1 more source
Advanced Science, EarlyView.To model a nutrient‐restricted tumor microenvironment, breast cancer cells were adapted to low glucose and glutamine levels. In the adapted cells, BRD4‐driven enhancer activation increases pro‐invasive EDN1 expression, facilitated by ATF3/c‐JUN and reinforced by enhancer RNA.
Poshan Yugal Bhattarai +4 more
wiley +1 more source
Immunoglobulin Light Chain Amyloidosis
Clinical Case ReportsSymmetric, purpuric hand nodules and macroglossia prompted skin biopsy revealing immunoglobulin light chain amyloidosis, leading to the diagnosis of multiple myeloma.
Justin Lyon +3 more
doaj +1 more source
Incidental hypervascular thyroid nodule in a 72-year-old female.
, 2016 (a) CE-MR angiography shows hypervascular thyroid nodule (arrow) in the right lobe. (b) Transverse US images reveal 1.15 cm size, well-defined hypoechogenic solid nodule with smooth margin and ovoid shape (arrows).
Hongil Ha (2504473) +3 more
core +1 more source