Results 91 to 100 of about 14,315,363 (291)

Chronologic Changes of Nitric Oxide Concentration in the Cochlear Lateral Wall and Its Role in Noise-Induced Permanent Threshold Shift

, 2011
OBJECTIVE: The objective of this study was to investigate the chronologic changes of nitric oxide (NO) concentration in the cochlear lateral wall and to explore its possible role in permanent threshold shift (PTS) after intense noise exposure.
CHEN, YUH-SHYANG;TSENG, FEN-YU;LIN, KAI-NAN;YANG, TING-HUA;LIN-SHIAU, SHOEI-YN;HSU, CHUAN-JEN, 陳玉祥;曾芬郁;林凱南;楊庭華;蕭水銀;許權振   +1 more
core   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity

FEBS Open Bio, EarlyView.
Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav, Shweta Shweta, Manisha Malhotra, Vikash Maurya, Akhilesh Kumar   +4 more
wiley   +1 more source

Audiological Symptoms Experienced by Taxi Drivers at Two Taxi Ranks in Johannesburg, South Africa

Noise and Health
Background: Noise-induced hearing loss (NIHL) is among the most common occupational health conditions worldwide. In South Africa, thousands of informal taxi drivers are chronically exposed to high traffic and environmental noise; however, data on their ...
Nomfundo Moroe
doaj   +1 more source

CDK2 inhibitors as candidate therapeutics for cisplatin- and noise-induced hearing loss

Journal of Experimental Medicine, 2018
Hearing loss caused by aging, noise, cisplatin toxicity, or other insults affects 360 million people worldwide, but there are no Food and Drug Administration–approved drugs to prevent or treat it. We screened 4,385 small molecules in a cochlear cell line
T. Teitz, Jie Fang, Asli N. Goktug, Justine D. Bonga, Shi-Yong Diao, Robert A. Hazlitt, Luigi I. Iconaru, Marie Morfouace, Duane G. Currier, Yin-Mei Zhou, R. A. Umans, Michael R. Taylor, Cheng Cheng, Jaeki Min, B. Freeman, Jun-Min Peng, M. F. Roussel, R. Kriwacki, R. Guy, Tao-Sheng Chen, J. Zuo   +20 more
semanticscholar   +1 more source

Using fluorescence fluctuation spectroscopy to quantify molecular dynamics within cells

FEBS Open Bio, EarlyView.
Microscopy techniques like fluorescence correlation spectroscopy (FCS) and number and brightness analysis (N&B) allow to quantify concentrations, diffusion rates, and oligomerization of fluorescently labeled molecules in the living cell. In this protocol the principles of how to set up these types of experiments are described including calibration ...
Mark A. Hink
wiley   +1 more source

Real-Time Synchronized Measurement of Preferred Listening Levels: Effects of Ambient Noise and Music Genre in Everyday Environments

Noise and Health
Background: Portable listening devices are widely used in daily activities, exposing users to music under highly variable ambient noise, and potentially increasing the risk of music-induced hearing loss.
Gibbeum Kim, Woojae Han
doaj   +1 more source

Risk of noise-induced hearing loss due to recreational sound: Review and recommendations.

Journal of the Acoustical Society of America, 2019
This review was conducted to address three questions related to recreational sound exposure: (1) what criteria are used to determine noise exposure limits, (2) are there differences in the risk of hearing loss from occupational noise versus recreational ...
R. Neitzel, B. Fligor
semanticscholar   +1 more source

Elevated Connectivity During Language Processing Is Associated With Cognitive Performance in SeLECTS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Self‐Limited Epilepsy with Centrotemporal Spikes (SeLECTS) is associated with language impairments despite seizures originating in the motor cortex, suggesting aberrant cross‐network interactions. Here we tested whether functional connectivity in SeLECTS during language tasks predicts language performance.
Wendy Qi, Katharine Lee, Kerry C. Nix, Miguel Menchaca, Xiwei Shé, Lorelei Santa Maria, Wei Wu, Zihuai He, Fiona M. Baumer   +8 more
wiley   +1 more source

Apoptosis in the cochlear nucleus and inferior colliculus upon repeated noise exposure

Noise and Health, 2018
The time course of apoptosis and the corresponding neuronal loss was previously shown in central auditory pathway of mice after a single noise exposure. However, repeated acoustic exposure is a major risk factor for noise-induced hearing loss.
Felix Fröhlich, Moritz Gröschel, Ira Strübing, Arne Ernst, Dietmar Basta   +4 more
doaj   +1 more source