Results 71 to 80 of about 14,315,363 (291)

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Inflammation associated with noise-induced hearing loss

Journal of the Acoustical Society of America, 2019
Inflammation is a complex biological response to harmful stimuli including infection, tissue damage, and toxins. Thus, it is not surprising that cochlear damage by noise includes an inflammatory component. One mechanism by which inflammation is generated
Mitchell D. Frye, A. Ryan, A. Kurabi
semanticscholar   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Investigation of the Audiological and Histological Results of Various Noise Exposure Protocols

Noise and Health
Objective: The objective of this study is to evaluate the effects of different noise conditions on the cochlea in rats. The study focuses on understanding noise-induced hearing loss through objective audiological tests and histological evaluations ...
Caner Yatmaz, Mustafa Bülent Şerbetçioğlu, Alev Cumbul   +2 more
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Mechanisms of noise-induced tinnitus: Insights from cellular studies

Neuron, 2019
Tinnitus, sound perception in the absence of physical stimuli, occurs in 15% of the population, and is the top-reported disability for soldiers after combat.
S. Shore, Calvin Wu
semanticscholar   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Drug-Therapeutic Strategies for Noise-Induced Hearing Loss: A Narrative Review

Noise and Health
With the rapid development of industrialisation, noise exposure is becoming increasingly prevalent. The detrimental effects of noise-induced hearing loss (NIHL) have become clinically relevant.
Zehui Deng, Fei Lin, Ling Zhou, Shaojuan Wang, Jie Li, Longxi He   +5 more
doaj   +1 more source

Noise-induced Cochlear Synaptopathy with and Without Sensory Cell Loss

Neuroscience, 2019
Prior work has provided extensive documentation of threshold sensitivity and sensory hair cell losses after noise exposure. It is now clear, however, that cochlear synaptic loss precedes such losses, at least at low-moderate noise doses, silencing ...
K. Fernandez, Dan Guo, Steven B Micucci, V. DeGruttola, M. Liberman, Sharon G. Kujawa   +5 more
semanticscholar   +1 more source

Association of pigmentation and melanocortin-one receptor genotype with susceptibility to noise-induced hearing loss in college-aged music students [PDF]

, 2017
Approximately 13% of the American population between the ages of 20-69 have signs of noise-induced hearing loss. Noise exposure at least partially causes hearing loss by generating free radicals in the ear, which damage cells. Eumelanin is an antioxidant
Pudrith, Charles Brian, NC DOCKS at The University of North Carolina at Greensboro   +1 more
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