Results 61 to 70 of about 14,315,363 (291)

The rat animal model for noise-induced hearing loss.

Journal of the Acoustical Society of America, 2019
Rats make excellent models for the study of medical, biological, genetic, and behavioral phenomena given their adaptability, robustness, survivability, and intelligence.
Celia D Escabi, Mitchell D. Frye, Monica Trevino, E. Lobarinas   +3 more
semanticscholar   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Experimental Investigation of Cavitation-Induced Acoustic Noise from Marine Propellers

, 2018
Ship-induced acoustic noise can be treated as a measure of environmental impact of marine transportation industry, where, if present, cavitation is often the dominant noise source.
Tani G., Viviani M., Iverson D., McIntyre D. W., Rahimpour M., Miglianti F., Oshkai P, Dong Z.   +7 more
core   +1 more source

Current insights in noise-induced hearing loss: a literature review of the underlying mechanism, pathophysiology, asymmetry, and management options

Journal of Otolaryngology - Head and Neck Surgery, 2017
BackgroundNoise-induced hearing loss is one of the most common forms of sensorineural hearing loss, is a major health problem, is largely preventable and is probably more widespread than revealed by conventional pure tone threshold testing. Noise-induced
T. Le, L. Straatman, Jane Lea, B. Westerberg   +3 more
semanticscholar   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Changes in the dynamical behavior of nonlinear systems induced by noise. [PDF]

, 2000
Weak noise acting upon a nonlinear dynamical system can have far-reaching consequences. The fundamental underlying problem - that of large deviations of a nonlinear system away from a stable or metastable state, sometimes resulting in a transition to a ...
Landa, P. S., McClintock, Peter V. E.
core   +4 more sources

Assessment of Noise Exposure and Risk of Hearing Loss for Young People in Amusement Arcades

Noise and Health
Background: Amusement arcades are one of the most popular entertainment venues for young people, but excessive noise levels inside them could harm young people’s hearing.
Nengsong Zou, Hongwei Wang, Zhixuan Huang, Qiaochu Wang   +3 more
doaj   +1 more source

The impact of gender and risk factors for hearing impairment on audiogram changes in military cadets during shooting exercises [PDF]

Vojnosanitetski Pregled
Background/Aim. Military personnel are frequently exposed to high levels of noise, where hearing loss can affect their combat performance. The aim of this study was to assess the impact of impulse noise produced by firearms during shooting exercises ...
Jovanović Vanja, Vojvodić Danilo, Jovanović Dejan, Marjanović Sonja   +3 more
doaj   +1 more source

Mitochondrial Calcium Transporters Mediate Sensitivity to Noise-Induced Losses of Hair Cells and Cochlear Synapses

Frontiers in Molecular Neuroscience, 2019
Mitochondria modulate cellular calcium homeostasis by the combined action of the mitochondrial calcium uniporter (MCU), a selective calcium entry channel, and the sodium calcium exchanger (NCLX), which extrudes calcium from mitochondria.
Xian-Ren Wang, Yuan-Ping Zhu, Haishan Long, Song Pan, Hao Xiong, Qiaojun Fang, Kayla Hill, R. Lai, Hu Yuan, Su-Hua Sha   +9 more
semanticscholar   +1 more source