Results 51 to 60 of about 801,940 (314)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Quantitative Evaluation of Environmental Loading Induced Displacement Products for Correcting GNSS Time Series in CMONOC

Remote Sensing, 2020
Mass redistribution within the Earth system deforms the surface elastically. Loading theory allows us to predict loading induced displacement anywhere on the Earth’s surface using environmental loading models, e.g., Global Land Data Assimilation ...
Chenfeng Li, Shengxiang Huang, Qiang Chen, Tonie van Dam, Hok Sum Fok, Qian Zhao, Weiwei Wu, Xinpeng Wang   +7 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Advancing Structural Health Monitoring with Deep Belief Network-Based Classification

Mathematics
Structural health monitoring (SHM) plays a critical role in ensuring the safety and longevity of civil infrastructure by enabling the early detection of structural changes and supporting preventive maintenance strategies.
Álvaro Presno Vélez, Zulima Fernández Muñiz, Juan Luis Fernández Martínez   +2 more
doaj   +1 more source

A Novel Approach for Modeling and Digital Generation of RF Signals Distorted by Bandlimited Phase Noise

IEEE Journal of Microwaves, 2022
In radar and communication systems, phase noise is one of the main causes of performance degradation. Phase noise increases the uncertainty in radar measurements and limits the achievable data rates in communication systems.
Peter Tschapek, Georg Korner, Patrick Fenske, Christian Carlowitz, Martin Vossiek   +4 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Analysis of Vibration and Noise in a Permanent Magnet Synchronous Motor Based on Temperature-Dependent Characteristics of Permanent Magnet

Energies, 2023
Interior permanent magnet synchronous motors (IPMSMs) are widely utilized due to their high power density. However, noise and vibration issues are often encountered in these motors.
Changhwan Kim, Gyeonghwan Yun, Sangjin Lee, Yongha Choo, Grace Firsta Lukman, Cheewoo Lee   +5 more
doaj   +1 more source

An experimental analysis of Noise-Contrastive Estimation: the noise distribution matters [PDF]

Proceedings of the 15th Conference of the European Chapter of the Association for Computational Linguistics: Volume 2, Short Papers, 2017
Noise Contrastive Estimation (NCE) is a learning procedure that is regularly used to train neural language models, since it avoids the computational bottleneck caused by the output softmax. In this paper, we attempt to explain some of the weaknesses of this objective function, and to draw directions for further developments. Experiments on a small task
Labeau, Matthieu, Allauzen, Alexandre
openaire   +2 more sources

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source