Results 21 to 30 of about 569,184 (264)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Numerical modeling techniques for noise emission of free railway wheels

Railway Engineering Science
In this article, we consider the numerical prediction of the noise emission from a wheelset in laboratory conditions. We focus on the fluid–structure interaction leading to sound emission in the fluid domain by analyzing three different methods to ...
Linus Taenzer, Urs Pachale, Bart Van Damme, Andrea Bergamini, Domenico Tallarico   +4 more
doaj   +1 more source

A Method for Determining the Optimal Location of a Distributed Sensor/Actuator

Shock and Vibration, 1994
The optimal location problem of distributed sensor/actuator for observation and control of a flexible structure is investigated. Using a property of controllability and observability grammian matrices, this approach employs a nonlinear optimization ...
Byeongsik Ko, Benson H. Tongue, Andrew Packard   +2 more
doaj   +1 more source

Adjusting Phenotypes by Noise Control

PLoS Computational Biology, 2012
Genetically identical cells can show phenotypic variability. This is often caused by stochastic events that originate from randomness in biochemical processes involving in gene expression and other extrinsic cellular processes. From an engineering perspective, there have been efforts focused on theory and experiments to control noise levels by ...
Kyung Hyuk Kim, Herbert M. Sauro
openaire   +4 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Effects of Background Sounds on Annoyance Reaction to Foreground Sounds in Psychoacoustic Experiments in the Laboratory: Limits and Consequences

Applied Sciences, 2019
In a variety of applications, e.g., psychoacoustic experiments, virtual sound propagation demonstration, or synthesized noise production, noise samples are played back in laboratories.
Armin Taghipour, Eduardo Pelizzari
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Study on the impact of Gurney flap parameters on rotor performance improvement

Hangkong gongcheng jinzhan
At present, most of the research on installing Gurney flaps is focused on two-dimensional airfoils. The three-dimensional blade model is established to investigate the influence of different Gurney flap parameters on rotor aerodynamic performance ...
LIU Shaoteng, LIU Xiangnan, SHAO Tianshuang, WANG Puyuan   +3 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source