Results 31 to 40 of about 2,187,801 (282)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Numerical modeling techniques for noise emission of free railway wheels

Railway Engineering Science
In this article, we consider the numerical prediction of the noise emission from a wheelset in laboratory conditions. We focus on the fluid–structure interaction leading to sound emission in the fluid domain by analyzing three different methods to ...
Linus Taenzer, Urs Pachale, Bart Van Damme, Andrea Bergamini, Domenico Tallarico   +4 more
doaj   +1 more source

A Method for Determining the Optimal Location of a Distributed Sensor/Actuator

Shock and Vibration, 1994
The optimal location problem of distributed sensor/actuator for observation and control of a flexible structure is investigated. Using a property of controllability and observability grammian matrices, this approach employs a nonlinear optimization ...
Byeongsik Ko, Benson H. Tongue, Andrew Packard   +2 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Effects of Background Sounds on Annoyance Reaction to Foreground Sounds in Psychoacoustic Experiments in the Laboratory: Limits and Consequences

Applied Sciences, 2019
In a variety of applications, e.g., psychoacoustic experiments, virtual sound propagation demonstration, or synthesized noise production, noise samples are played back in laboratories.
Armin Taghipour, Eduardo Pelizzari
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Study on the impact of Gurney flap parameters on rotor performance improvement

Hangkong gongcheng jinzhan
At present, most of the research on installing Gurney flaps is focused on two-dimensional airfoils. The three-dimensional blade model is established to investigate the influence of different Gurney flap parameters on rotor aerodynamic performance ...
LIU Shaoteng, LIU Xiangnan, SHAO Tianshuang, WANG Puyuan   +3 more
doaj   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Nonlinear Responses and Stability of an Elastic Suspended Cable System Subjected to Parametrical External Excitations

Nonlinear Engineering, 2017
This research investigates the nonlinear behavior and stability of an elastic suspended cable system under combined parametric and external excitations, with an approach of higher accuracy and reliability.
Dai Liming, Xia Dandan, Chen Changping
doaj   +1 more source