Results 61 to 70 of about 2,194,885 (334)

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Lipophilic components of diesel exhaust particles induce pro-inflammatory responses in human endothelial cells through AhR dependent pathway(s)

Particle and Fibre Toxicology, 2018
Background Exposure to traffic-derived particulate matter (PM), such as diesel exhaust particles (DEP), is a leading environmental cause of cardiovascular disease (CVD), and may contribute to endothelial dysfunction and development of atherosclerosis. It
Bendik C. Brinchmann, Tonje Skuland, Mia H. Rambøl, Krisztina Szoke, Jan E. Brinchmann, Arno C. Gutleb, Elisa Moschini, Alena Kubátová, Klara Kukowski, Eric Le Ferrec, Dominique Lagadic-Gossmann, Per E. Schwarze, Marit Låg, Magne Refsnes, Johan Øvrevik, Jørn A. Holme   +15 more
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Experimental study of the flow around two finite square cylinders

Archives of Mechanics, 2018
An experimental investigation is conducted on the air flow past two wallmounted finite length side-by-side square cylinders, each of the aspect ratio AR = 7. The cylinder center-to-center spacing ratio T/d is varied from 2 to 6, where d is the side-width
A. Sohankar, M. Abbasi, M. Nili-Ahmadabadi, MD. Mahbud Alam, F. Zafar   +4 more
doaj   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Prediction for Outlet Noise of Rolling Piston Comperssor

MATEC Web of Conferences, 2015
An acoustic wave equation with considering small perturbation is presented first by use of the fluidic mechanics and aerodynamics, then a theoretical model for predicting the outlet noise of rolling piston compressors is investigated, and the sound ...
Zhang Tieshan
doaj   +1 more source

Optimal control of the signal to noise ratio per unit time for a spin 1/2 particle

, 2014
We investigate the maximum signal to noise ratio per unit time that can be achieved for a spin 1/2 particle subjected to a periodic pulse sequence. Optimal control techniques are applied to design the control field and the position of the steady state ...
Assémat, E., Glaser, S. J., Lapert, M., Sugny, D.   +3 more
core   +1 more source

Network Localization of Fatigue in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Fatigue is among the most common symptoms and one of the main factors determining the quality of life in multiple sclerosis (MS). However, the neurobiological mechanisms underlying fatigue are not fully understood. Here we studied lesion locations and their connections in individuals with MS, aiming to identify brain networks ...
Olli Likitalo, Jaakko Kungshamn, Albert Bellmunt‐Gil, Silvia Tommasin, Abhineet Ojha, Matias Viitala, Juho Aaltonen, Jyrki Lötjönen, Juha Koikkalainen, Pauli Ylikotila, Patrizia Pantano, Merja Soilu‐Hänninen, Juho Joutsa   +12 more
wiley   +1 more source

Semi-Automated Classification of Side-Scan Sonar Data for Mapping Sabellaria spinulosa Reefs in the Brown Bank, Dutch Continental Shelf

Journal of Marine Science and Engineering
Biogenic reefs support marine biodiversity and play a key role in a healthy marine environment. Protecting and enhancing reef-building species, such as Sabellaria spinulosa, require mapping and monitoring strategies.
Timo Constantin Gaida, Bas Binnerts, Oscar Bos   +2 more
doaj   +1 more source