Results 31 to 40 of about 217,808 (315)

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Firefighters' noise exposure: A literature review [PDF]

International Archives of Otorhinolaryngology, 2014
 To review the literature about the effects of environmental noise on the hearing ability of firefighters. The PubMed and Scielo databases were searched and studies from 2002 to 2012 that included the keywords firefighters, noise, and hearing loss were identified.
Taxini, Carla Linhares, Guida, Heraldo Lorena   +1 more
openaire   +8 more sources

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Noise exposure in occupational setting associated with elevated blood pressure in China

BMC Public Health, 2017
Background Hypertension is the primary out-auditory adverse outcome caused due to occupational noise exposure. This study investigated the associations of noise exposure in an occupational setting with blood pressure and risk of hypertension.
Shuchang Chen, Yaqin Ni, Lei Zhang, Liya Kong, Luying Lu, Zhangping Yang, Luoxian Yang, Xuhui Zhang, Yimin Zhu   +8 more
doaj   +1 more source

Repeated Moderate Noise Exposure in the Rat—an Early Adulthood Noise Exposure Model [PDF]

Journal of the Association for Research in Otolaryngology, 2015
In this study, we investigated the effects of varying intensity levels of repeated moderate noise exposures on hearing. The aim was to define an appropriate intensity level that could be repeated several times without giving rise to a permanent hearing loss, and thus establish a model for early adulthood moderate noise exposure in rats.
Paula Mannström, Mette Kirkegaard, Mats Ulfendahl   +2 more
openaire   +2 more sources

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Hearing in young adults. Part II: The effects of recreational noise exposure

Noise and Health, 2015
Great concern arises from recreational noise exposure, which might lead to noise-induced hearing loss in young adults. The objective of the current study was to evaluate the effects of recreational noise exposure on hearing function in young adults.
Hannah Keppler, Ingeborg Dhooge, Bart Vinck   +2 more
doaj   +1 more source

Measuring method of occupational non-Gaussian noise exposure based on kurtosis adjustment

环境与职业医学, 2022
The existing measuring methods of noise exposure on the basis of equal energy hypothesis are applicable to Gaussian noise while not fully applicable to non-Gaussian noise.
Yong HU, Zhihao SHI, Xiangjing GAO, Jiarui XIN, Lifang ZHOU, Meibian ZHANG   +5 more
doaj   +1 more source

Impact of daily noise exposure monitoring on occupational noise exposures in manufacturing workers [PDF]

International Journal of Audiology, 2013
Despite the use of hearing protection devices (HPDs), noise induced hearing loss (NIHL) remains one of the most prevalent occupational conditions. A new technology allows for daily monitoring of noise exposures under HPDs. We report on an intervention employing the voluntary use of this technology in a worksite setting.Volunteers were fitted with a ...
Michael F, McTague, Deron, Galusha, Christine, Dixon-Ernst, Sharon R, Kirsche, Martin D, Slade, Mark R, Cullen, Peter M, Rabinowitz   +6 more
openaire   +2 more sources