Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
Analysis and Design of Inductorless Wideband Low-Noise Amplifier With Noise Cancellation Technique
This paper deals with the fabrication of an inductorless wideband low-noise amplifier (LNA). The LNA includes two branches in parallel: a common-source (CS) path and a common-gate (CG) path.
Yiming Yu +7 more
doaj +1 more source
Hysteresis and Noise in Stripe and Clump Forming Systems
We use simulations to examine hysteresis and noise in a model system that produces heterogeneous orderings including stripe and clump phases. In the presence of a disordered substrate, these heterogeneous phases exhibit 1/f$^\alpha$ noise and hysteresis ...
A. R Bishop +4 more
core +1 more source
A wideband high-linearity RF receiver front-end in CMOS [PDF]
This paper presents a wideband high-linearity RF receiver-front-end, implemented in standard 0.18 /spl mu/m CMOS technology. The design employs a noise-canceling LNA in combination with two passive mixers, followed by lowpass-filtering and amplification ...
Arkesteijn, Vincent J. +2 more
core +2 more sources
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source
Pareto Optimal Characterization of a Microwave Transistor
Herein, noise, gain and port mismatchings of a microwave small-signal transistor are expressed as all the set of acceptable Pareto optimal solutions and trade-off relations within the device operation (VDS, IDS,f) domain without any need of expert ...
Filiz Gunes +2 more
doaj +1 more source
Fundamental noise limitations to supercontinuum generation in microstructure fiber
Broadband noise on supercontinuum spectra generated in microstructure fiber is shown to lead to amplitude fluctuations as large as 50 % for certain input laser pulse parameters.
Coen, S. +6 more
core +2 more sources
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
Design and Simulation of a Low-Noise Amplifier (LNA) with low power consumption and high gain in 2.4GHz frequency for wireless systems [PDF]
This paper presents the design and simulation of low-noise amplifier (LNA) with .18CMOS technology in 2.4GHz frequency addressed, the process HSPICE RF simulation software has been done.
Esmaeel Karimi, Ebrahim Borzabadi
doaj
Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee +3 more
wiley +1 more source

