Results 81 to 90 of about 213,145 (308)

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

Varieties of Noise: Analogical Reasoning in Synthetic Biology [PDF]

open access: yes, 2013
The picture of synthetic biology as a kind of engineering science has largely created the public understanding of this novel field, covering both its promises and risks.
Knuuttila, Tarja, Loettgers, Andrea
core  

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

open access: yesFEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee   +3 more
wiley   +1 more source

A case study of recording soundwalk of Fushimi Inari shrine in Kyoto, Japan using smartphone

open access: yesNoise Mapping, 2019
We present soundwalk of Fushimi Inari Shrine in Kyoto, Japan from the main gate facing the Inari railway station to the summit. The soundwalk was captured from Samsung Galaxy S8 running NoiseExplorer: an app we have developed for Android and iOS. Fushimi
Lee Heow Pueh   +2 more
doaj   +1 more source

Spatial Interpolation contribution to noise maps uncertainty

open access: yes, 2010
Noise maps results are usually presented as contour graphs or isophone curves, which describe the sound levels as functions of spatial location. These maps are added to Geographic Information Systems (GIS), allowing sound level evaluation as a function
Ausejo Prieto, Miguel   +4 more
core  

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

open access: yesFEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour   +2 more
wiley   +1 more source

A note on the acoustic environment in a usually quiet residential area after the ‘state of emergency’ declaration due to COVID-19 pandemic in Japan was lifted: supplementary survey results in post-emergency situations

open access: yesNoise Mapping, 2020
In a preceding report (UCL Open: Environment, 2020;1;6), an example of results on changes in the acoustic environment from a local-scale survey in a quiet residential area during and after the ‘state of emergency’ due to COVID-19 pandemic in Japan is ...
Sakagami Kimihiro
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

open access: yesFEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova   +2 more
wiley   +1 more source

Global noise score indicator for classroom evaluation of acoustic performances in LIFE GIOCONDA project

open access: yesNoise Mapping, 2016
The LIFE GIOCONDA is an ongoing project that aims to provide an innovative methodology to the authorities for supporting the environment & health policies by involving the young people in the decision-making processes. The project suggests a web platform
Chetoni Marco   +5 more
doaj   +1 more source

Clustering Algorithm Reveals Dopamine‐Motor Mismatch in Cognitively Preserved Parkinson's Disease

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore the relationship between dopaminergic denervation and motor impairment in two de novo Parkinson's disease (PD) cohorts. Methods n = 249 PD patients from Parkinson's Progression Markers Initiative (PPMI) and n = 84 from an external clinical cohort.
Rachele Malito   +14 more
wiley   +1 more source

Home - About - Disclaimer - Privacy