Results 51 to 60 of about 2,969,604 (339)

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

SmoothGrad: removing noise by adding noise

, 2017
Explaining the output of a deep network remains a challenge. In the case of an image classifier, one type of explanation is to identify pixels that strongly influence the final decision. A starting point for this strategy is the gradient of the class score function with respect to the input image.
Smilkov, Daniel, Thorat, Nikhil, Kim, Been, Viégas, Fernanda, Wattenberg, Martin   +4 more
openaire   +2 more sources

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Multi-Class Diagnosis of Neurodegenerative Diseases Using Effective Deep Learning Models With Modified DenseNet-169 and Enhanced DeepLabV 3+

IEEE Access
Early detection lowers the death rate and allows for prompt treatment of the exhausted individual with neurodegenerative diseases. Most existing classification studies can either not generate probabilistic predictions or consider uncertainty, or do not ...
Srinivas Katkam, V. Prema Tulasi, B. Dhanalaxmi, J. Harikiran   +3 more
doaj   +1 more source

Algorithms of statistical anomalies clearing for data science applications

Sistemnì Doslìdženâ ta Informacìjnì Tehnologìï, 2023
The paper considers the nature of input data used by Data Science algorithms of modern-day application domains. It then proposes three algorithms designed to remove statistical anomalies from datasets as a part of the Data Science pipeline.
Oleksii Pysarchuk, Danylo Baran, Yurii Mironov, Illya Pysarchuk   +3 more
doaj   +1 more source

Hybrid Noise Removal in Hyperspectral Imagery With a Spatial–Spectral Gradient Network [PDF]

IEEE Transactions on Geoscience and Remote Sensing, 2018
The existence of hybrid noise in hyperspectral images (HSIs) severely degrades the data quality, reduces the interpretation accuracy of HSIs, and restricts the subsequent HSI applications.
Qiang Zhang, Qiangqiang Yuan, Jie Li, Xinxin Liu, Huanfeng Shen, Liangpei Zhang   +5 more
semanticscholar   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

MACROECONOMIC NOISE REMOVAL ALGORITHM (MARINER)

Technological and Economic Development of Economy, 2017
Standard econometric filters fail to extract explicit trend component from macroeconomic data series. Isolated cycles provide no economic interpretation of the extracted component. Adding new data to the sample (filtering) period results in instability of extracted components.
openaire   +4 more sources

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source