Results 61 to 70 of about 305,947 (290)
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Quantization Noise Shaping on Arbitrary Frame Expansions
EURASIP Journal on Advances in Signal Processing, 2006 Quantization noise shaping is commonly used in oversampled A/D and D/A converters with uniform sampling. This paper considers quantization noise shaping for arbitrary finite frame expansions based on generalizing the view of first-order classical ...
Boufounos Petros T, Oppenheim Alan V
doaj +1 more source
Discrimination of Gain Increments in Speech-Shaped Noises [PDF]
Trends in Hearing, 2019 Frequency-dependent gain adjustments are routine in hearing-aid fittings, whether in matching to real-ear targets or fine-tuning to patient feedback. Patient feedback may be unreliable and fittings inefficient if adjustments are not discriminable. To examine what gain adjustments are discriminable, we measured the just-noticeable differences (JNDs ...
Benjamin Caswell-Midwinter +1 more
openaire +4 more sources
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Effect of disorder and noise in shaping the dynamics of power grids
, 2018 The aim of this paper is to investigate complex dynamic networks which can model high-voltage power grids with renewable, fluctuating energy sources.
Olmi, Simona +2 more
core +2 more sources
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
JPhys PhotonicsInterferometry often serves as an essential building block of wavefront shaping systems to obtain optimal wavefront solutions. In this tutorial, we provide a Monte Carlo simulation tool to calculate the accuracy of interferometric measurements and its ...
Chunghyeong Lee +3 more
doaj +1 more source
CMOS time-to-digital converters for mixed-mode signal processing
The Journal of Engineering, 2014 This study provides an in-depth review of the principles, architectures and design techniques of CMOS time-to-digital converters (TDCs). The classification of TDCs is introduced.
Fei Yuan
doaj +1 more source
FEBS Open Bio, EarlyView.Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley +1 more source