Results 91 to 100 of about 5,709,684 (288)

Fzd7 Restrains Pink1‐Dependent Mitophagy in Suture Stem Cells to Maintain Cranial Suture Patency

open access: yesAdvanced Science, EarlyView.
How suture stem cells fail to preserve cranial suture patency remains incompletely understood. Integrated single‐cell and high‐resolution spatial transcriptomic analyses identify reduced Fzd7 expression in Prrx1+ suture stem cells as an early feature of craniosynostosis.
Xinyan Chen   +10 more
wiley   +1 more source

The National Global Change Research Plan 2012-2021: A Triennial Update

open access: yes, 2017
This report is the third triennial update of the National Global Change Research Plan based on scientific research from 13 Federal agencies. The purpose of each update is to "advance science, inform decisions, conduct...assessments" and communicate ...
U.S. Global Change Research Program
core  

Race: a call to change nomenclature [PDF]

open access: yesKidney International, 2009
Ritz, Eberhard, Naicker, Sarala
openaire   +2 more sources

α‐Synuclein Forms Distinct Micelle‐Like Assemblies at Low Ionic Strengths

open access: yesAdvanced Science, EarlyView.
At high ionic strength, α‐synuclein forms diverse assemblies, including oligomers, fibrils, and condensates. Here, we show that at low ionic strength, α‐synuclein adopts a distinct, low‐abundance assembly state. These assemblies maintain a constant size above a critical concentration and do not coalesce, suggesting a micelle‐like organization ...
Sophie Hertel   +10 more
wiley   +1 more source

Nomenclatural databases [PDF]

open access: yes, 1998
The definition of nomenclature differs from dictionary to dictionary but suffice to say a nomenclatural database will deal with the name of an organism and the specimens that bring information regarding the name. There are a number of databases that will
Cowan, R.A.
core  

Dual pKa Lipid Nanoparticles for Lung‐tropic mRNA Delivery and pH‐Programmed Endosomal Escape

open access: yesAdvanced Science, EarlyView.
Lipid nanoparticles’ bottleneck lies in low endosomal escape efficiency and liver‐dominant delivery after intravenous administration. To overcome these limitations, we present a stepwise pH‐programmed lipid nanoparticle system enabled by our newly synthesized ionizable lipid.
Seong Gi Lim   +12 more
wiley   +1 more source

14‐3‐3γ Protects Against Postoperative Cognitive Dysfunction by Regulating Tau Thr205 Phosphorylation and Synaptic Integrity

open access: yesAdvanced Science, EarlyView.
Integrative multi‐cohort analyses identify 14‐3‐3γ as a biomarker and regulator of cognitive vulnerability. Experimental studies show that 14‐3‐3γ loss is associated with Tau Thr205 phosphorylation, synaptic dysfunction, and cognitive impairment, while genetic overexpression or pharmacological stabilization of 14‐3‐3γ confers protective effects in ...
Shouqiang Zhu   +5 more
wiley   +1 more source

Preface

open access: yes, 2008
This is an excerpt of a report series produced by the U.S. Climate Change Science Program (CCSP) aimed at providing current assessments of climate change science to inform public debate, policy, and operational decisions.
Subcommittee on Global Change Research   +1 more
core  

A State‐Gated Metallo‐DNAzyme Framework Programs Tumor Stress Vulnerability Through Metabolic Licensing

open access: yesAdvanced Science, EarlyView.
A tumor‐state‐gated metallo‐DNAzyme framework integrates miR‐21/APE1‐responsive GLUT1 silencing with Ca/Cu‐partitioned metal–nucleic acid assembly and cystine loading. The framework first weakens glucose‐dependent metabolic buffering and then amplifies copper‐ and disulfide‐associated stress, converting tumor metabolic adaptation into programmable ...
Xiaodong Ma   +8 more
wiley   +1 more source

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