Results 41 to 50 of about 299,428 (286)
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
<h2>What's Changed</h2> <ul> <li>Allow nomenclatureconfig to have region country only by @phackstock in https://github.com/IAMconsortium/nomenclature/pull/320</li> <li>Making aggregation compatible with pyam 2.1 by ...
Hackstock, Philip +3 more
core +2 more sources
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Naming the alpha-2-macroglobulin gene family across vertebrates
Human GenomicsThe HUGO Gene Nomenclature Committee (HGNC) assigns unique symbols and names to human genes and its sister project, the Vertebrate Gene Nomenclature Committee (VGNC), names genes across selected vertebrates (chimp, macaque, horse, cattle, pig, dog, cat ...
Bryony Braschi +2 more
doaj +1 more source
Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains
FEBS Open Bio, EarlyView.The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth +6 more
wiley +1 more source
IMA FungusA commentary is provided on the seven formally published proposals to modify the provisions of Chapter F of the International Code of Nomenclature for algae, fungi, and plants (ICNafp) that will be dealt with by the Fungal Nomenclature Session (FNS) of ...
Tom W. May, Konstanze Bensch
doaj +1 more source
Notes on systematics and taxonomy for the Italian vascular flora. 2.
Natural History Sciences, 2011 The present study forms part of the series of systematic and taxonomic contributions related to plant species of the Italian flora, and also other phanerogams, in light of recent biosystematic works of a molecular-genetic nature.
Enrico Banfi +2 more
doaj +1 more source