Results 41 to 50 of about 2,172 (309)

A Surprising Closeness in Latin American Academia: Luther and Certain Neurosciences

open access: yesOpen Theology, 2018
The purpose of this paper is to show a surprising coincidence between Lutheran Protestantism and physicalist neurosciences regarding the negation of free will and how this issue can begin to be studied in Latin American academia.
Martínez-Barrera Jorge
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Assumptions Concerning the Social Sciences

open access: yesAmerican Journal of Islam and Society, 1993
This paper comprises three major sections. The first section discusses modem social assumptions concerning the existence of human beings and their societies. It also explains the impact of these assumptions on organizational theory.
Ebtihaj Al-A‘ali
doaj   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

open access: yesFEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim   +4 more
wiley   +1 more source

U zródeł współczesnego nominalizmu w filozofii matematyki

open access: yesZagadnienia Filozoficzne w Nauce, 2006
Nominalism is one of the most important positions in the contemporary philosophy of mathematics. The goal of this article is to point out various factors that have effected the rapid development of nominalism.
Anna Frąckowiak–Ciesielska
doaj  

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

open access: yesAging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss   +12 more
wiley   +1 more source

Fictionalism and the problem of universals in the philosophy of mathematics [PDF]

open access: yesFilozofija i Društvo, 2018
Many long-standing problems pertaining to contemporary philosophy of mathematics can be traced back to different approaches in determining the nature of mathematical entities which have been dominated by the debate between realists and ...
Đorđević Strahinja
doaj   +1 more source

E. Durkheim’s concept of sacredness

open access: yesRUDN journal of Sociology, 2022
E. Durkheim’s concept of sacredness as formulated in The Elementary Forms of the Religious Life aims at explaining why and how an aggregate of people becomes ‘a single whole’ and reproduces itself.
A. E. Kapishin
doaj   +1 more source

Nominal rewriting

open access: yesInformation and Computation, 2007
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Maribel Fernández, Murdoch Gabbay
openaire   +2 more sources

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling   +16 more
wiley   +1 more source

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