Results 61 to 70 of about 57,334 (297)
Advanced Science, EarlyView.Our study identifies an Hnf4a‐driven super‐enhancer of hepatic Ahcy that mediates the protective effects of intermittent fasting against MASLD. Disruption of the Ahcy super‐enhancer reduces Ahcy expression and exacerbates lipid accumulation. This pathway prevents aberrant promoter hypermethylation by maintaining the SAM/SAH balance, as exemplified by ...
Huafeng Chen +6 more
wiley +1 more source
Review of the Monograph “Linguistic Tuning Forks of Meaning” by V.I. Karasik [PDF]
Актуальные проблемы филологии и педагогической лингвистикиThe monograph is devoted to the issues of linguaculturology, linguasemiotics and discourse studies. It consists of four thematic sections: linguaconceptology, narratology, discourse science and the section devoted to the study of the axiological ...
Sergey G. Vorkachev
doaj +1 more source
How Serious are Methodological Issues in Surveys? A Reexamination of the Clarence Thomas Polls^T [PDF]
Opinion polling procedures allow for reasonable inferences about attitude changes. We examined this contention using surveys about the nomination of Clarence Thomas.
F. Collopy, J. S. Armstrong
core
Systematic Multi‐Level Analyses Decode the Arthritis‐Neurodegeneration Axis With In Vivo Validation
Advanced Science, EarlyView.Arthritis and neurodegeneration are usually studied as separate disorders, but this study connects them through population evidence, genetic inference, transcriptomic mapping, and mouse models. It highlights RNF40 as a context‐dependent joint‐brain candidate, induced in inflammatory joints yet functionally linked to dopamine‐neuron vulnerability ...
Jinwen Wang +7 more
wiley +1 more source
Nomination Papers Envelope [PDF]
, 2018 1947-1948, Louis-Philippe Gagne nomination papers envelope.https://digitalcommons.usm.maine.edu/fac-lpg-nomination-papers/1000/thumbnail ...
Gagne, Louis-Philippe
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Development of a Teacher Rating Scale for Giftedness (TRSG)
Acta Educationis GeneralisIntellectual giftedness is an important student characteristic that teachers need to take into consideration when designing education programs and providing educational support to these students.
Aydın-Karaca Şeyda, Kılınç Şule
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Advanced Science, EarlyView.Rhoifolin directly targets NMNAT1, thereby activating nicotinamide salvage pathway and promoting intracellular NAD+ biosynthesis. Elevated NAD+ levels enhance SIRT1 activity, leading to FOXO1 deacetylation and nuclear translocation. Nuclear FOXO1 subsequently binds to the IL‐22 promoter, upregulating IL‐22 transcription and potentiating ILC3 effector ...
Hongqiong Yang +12 more
wiley +1 more source
Актуальні питання суспільних наук та історії медицини, 2017 Лариса Шутак. Вторичные наименования как один из способов реализации стоматологического дискурса. Рассмотрены в частности вторичные лексемы – названия инструментов, деталей инструментов; названия органов и их частей, создаваемых за внешним сходством ...
Лариса ШУТАК
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Advanced Science, EarlyView.Embryonic amoxicillin exposure disrupts multi‐organ development in zebrafish larvae through a lncRNA–metabolic enzyme regulatory axis. PCALRx associates with pyruvate carboxylase, promotes PC protein ubiquitination, and impairs mitochondrial energy metabolism, while vitamin B1 partially restores PC‐centered metabolic function and developmental outcomes.
Yixue Yao +5 more
wiley +1 more source