Results 41 to 50 of about 1,135,563 (256)

Single‐Cell Dissection of Microglial Dysfunction in Diabetes‐Associated Neurodegenerative Vulnerability

Advanced Science, EarlyView.
Using single‐cell transcriptomic and epigenomic profiling, researchers mapped microglial dysfunction across the lifespan of db/db mice. The authors uncovered a nonlinear microglial remodeling featuring early inflammatory priming, a mid‐stage transcriptional inflection, and late dysfunction.
Jizhou Zhang, Tsz Kwan Yau, Joyce Tse, Tsz Ho Li, Dongjie Hu, Yong Juan Zhao, Ting‐Fung Chan   +6 more
wiley   +1 more source

Nomination - Benjamin Civiletti - Votes in Committee

, 1978
Printed card recording the votes of the U.S. Senate, Committee on the Judiciary on Civilett\u27s nomination to be Attorney General of the United States. Signed by Senator James D.

core   +1 more source

BEST PRACTICES REGARDING THE ORGANIZATION AND FUNCTIONING OF AUDIT COMMITTEES [PDF]

Annals of the University of Petrosani: Economics, 2012
The article intends to identify best practices regarding the organization and functioning of audit committees in the corporate governance codes, listing requirements of stock exchanges and views of practitioners.
ADRIAN POPA, DRAGOȘ LAURENȚIU ZAHARIA, ANI DUMITRACHE   +2 more
doaj  

Photobiomodulation‑Engineered Extracellular Vesicles Enhance Neural Differentiation via UFL1‑Mediated UFMylation in Spinal Cord Injury

Advanced Science, EarlyView.
Photobiomodulated microglia release engineered extracellular vesicles that deliver UFL1 to the injured spinal cord. UFL1 competitively binds p53 with MDM2, inhibiting p53 ubiquitination and stabilizing p53 signaling. This dual mechanism simultaneously promotes anti‐inflammatory microglial polarization and directs neural stem cell differentiation toward
Yunxiao Fang, Zuomeng Wu, Ruocheng Guo, Cancan Wang, Yue Qin, Yixiang Dong, Aoyun Li, Ao Liu, Chongyu Jia, Tianyu Han, Peiwen Song, Lei Chen, Cailiang Shen   +12 more
wiley   +1 more source

Minutes: Civil Service Consultative Committee: November 18, 2021

, 2021
Resolution Concerning Caste-Based Discrimination; Vote: Approve Duluth Civil Service Senator Nomination; Office of Human Resources Updates; PACC Updates; Chairs ReportUniversity of Minnesota: Civil Service Consultative Committee. (2021).
University of Minnesota: Civil Service Consultative Committee
core  

A Biofabricated Human Acinus‐on‐a‐Chip Unveils Mechanotransductive Drivers of Ventilator‐Induced Lung Injury via Decoupling Volutrauma and Barotrauma

Advanced Science, EarlyView.
This bioinspired acinus‐on‐a‐chip recapitulates VILI pathology, revealing that volutrauma drives P53/NF‐κB pathways while barotrauma triggers mitochondrial‐Wnt dysregulation. A fibrotic transitional cell cluster was identified. Pharmacological interventions targeting these pathways significantly ameliorated injury, establishing a mechanobiological ...
Heng Lu, Liansheng Liu, Zengyong Hu, Shuxian Fang, Ruohan Ren, Sidi Liu, Meng Zhao, Zhiting Luo, Ziyue Zhang, Wenlong Shao, Qian Liu   +10 more
wiley   +1 more source

The roles of the SCAB Nominations and Activities systems in the ATLAS-CERN speakers selection [PDF]

EPJ Web of Conferences
Considering CERN’s prosperous environment, developing groundbreaking research in physics, and pushing technology’s barriers, CERN members participate in many talks and conferences every year.
Niklaus Moreira da Rocha Rodrigues Carolina, Loureiro Cruz Ana Clara, Lemos Lúcidi Pinhão Gabriela, Mira Marins Leonardo, Goes Afonso Pedro Henrique, Lenzi Romano Rafaella, Coura Torres Rodrigo, Nunes de Moura Junior Natanael, Seixas José Manoel   +8 more
doaj   +1 more source

The enactment of physician-authors in Nobel Prize nominations.

PLoS ONE, 2020
Several physicians have been nominated for the Nobel Prize in literature, but so far none of them have received it. Because physicians as women and men of letters have been a major topic of feuilletons, seminars and books for many years, questions arise ...
Nils Hansson, Peter M Nilsson, Heiner Fangerau, Jonatan Wistrand   +3 more
doaj   +1 more source

Committee meeting before Senate Judiciary Committee - Nomination interview of Christopher J. Daggett to be the commissioner of the New Jersey Department of Environmental Protection

, 1989
Transcript of hearing held before the NJ Senate Judiciary Committee on January 5, 1989 concerning the nomination of Christopher J.

core   +1 more source

Uncoupling Type I Interferon Benefits From Inflammatory Toxicity: Transformer‐Prioritized Precision Agonists for Potent and Safer Cancer Immunotherapy

Advanced Science, EarlyView.
A Transformer‐based AI framework, DLINP, screens millions of compounds to identify Co68, a cobalt‐pincer organometallic complex that biases TLR4‐MD2 signaling toward antitumor interferon activation while suppressing inflammatory toxicity through an early TLR4‐SYK‐STAT1 axis.
Xuefei Guo, Yang Zhao, Xianle Rong, Xingyu Chen, Xiao Wang, Tianyi Liu, Yunfei Xie, Yushu Zou, Pingsen Zhao, Qiang Liu, Fuping You   +10 more
wiley   +1 more source