Results 61 to 70 of about 1,135,563 (256)

KLF5 Downregulation Links Impaired BNIP3‐Mediated Mitophagy to Inflammatory Valve Remodeling in Calcific Aortic Valve Disease

Advanced Science, EarlyView.
In human CAVD, KLF5 is reduced in VIC‐rich regions and remodeling/stress‐associated VIC states. In VICs, KLF5 sustains BNIP3 promoter activity and BNIP3‐mediated mitophagy, thereby limiting cytosolic mtDNA accumulation. KLF5 loss weakens mitochondrial quality control and enhances mtDNA‐sensitive STING/NF‐κB/NLRP3 inflammatory signaling under osteogenic
Jin‐Hui Bian, Jia‐Xi Gu, Zhang Yue, Chun‐Ze Yuan, Hai‐Bin Ji, Ao Li, Yu Zhong, Xiu‐Fan Xu, Yu‐Qiu He, Ye‐Fan Jiang, Hong‐Shan Chen, Xiang Chen, Meng‐Lin Chao, Yong‐Feng Shao   +13 more
wiley   +1 more source

Multi‐Technique Integration Identifies O‐GlcNAc Transferase in Fibroblast‐Like Synoviocytes as a Therapeutic Target for Rheumatoid Arthritis

Advanced Science, EarlyView.
AI‑guided single‑cell transcriptomics identifies OGT as a key regulator enriched in rheumatoid arthritis fibroblast‑like synoviocytes (RA‐FLSs). Inflammatory stimuli activate the OGT–SAP130 axis, which modulates the H3K27ac/H3K27me3 balance and epigenetically silences BTG2, promoting aggressive transformation of RA‑FLSs.
Duoli Xie, Jie Huang, Chunhao Cao, Zhenchao Tang, Xingchen Li, Jianmin Guo, Xinxin Chen, Fang Wang, Dongyi He, Jie Li, Yu Du, Bing He, Jianhua Yao, Aiping Lu, Chao Liang   +14 more
wiley   +1 more source

[Letter from Sue Gibson to the Extra Mile Awards Committee, February 6, 1990]

, 1990
Letter from Sue Gibson to the Extra Mile Awards Committee discussing Gibson's nomination of Christine M.
Gibson, Sue
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حوكمة لجان مجلس إدارة شركة المساهمة المدرجة في السوق المالية السعودية (دراسة تحليلية) / Governance of the Board of Directors committees of joint stock companies listed on the Saudi Stock Exchange (Analytical study) [PDF]

مجلة البحوث الفقهیة والقانونیة
تناول هذا البحث دراسة وتحليل موضوع حوكمة لجان مجلس إدارة شركة المساهمة المدرجة في السوق المالية السعودية "دراسة تحليلية"، حيث سعى البحث إلى الوقوف على ماهية حوكمة شركة المساهمة وكيفية تشكيل اللجان المنبثقة عن مجلس إدارة شركة المساهمة المدرجة في السوق ...
سليمان الجهني
doaj   +1 more source

AARS1‐Mediated H3K27 Lactylation Rewires Glycolysis to Sustain Aggressive and Recurrent Bladder Cancer

Advanced Science, EarlyView.
AARS1 drives PI3K–AKT–mTOR‐dependent glycolysis in bladder cancer, promoting lactate accumulation, increased lactylation, H3K27la enrichment at the HK2 promoter, and HK2 transcription. HK2 reinforces glycolysis, sustaining a metabolic–epigenetic program associated with tumor progression, recurrence, and metastasis.
Qin Yuan, Tianbao Song, Yipeng He, Sihan Xia, Yaoqiu Huang, Wenlin He, Qin Yi, Zefeng Wang, Peihan Wang, Chenbo Huang, Linzhi Li, Zhen Yin, Fan Cheng, Weimin Yu   +13 more
wiley   +1 more source

Oligosaccharides With Defined Glycosidic Bonds Shape Gut Microbial Succession and Metabolism Via Bond‐Specific Microbial Responders

Advanced Science, EarlyView.
Oligosaccharides with defined glycosidic bonds drive divergent gut microbial succession and shape unique metabolic profiles. Absolute time‐series profiling with Bayesian generalized Lotka–Volterra modeling identifies bond‐specific microbial responders, while monoculture validation and metaproteomics reveal linkage‐matched transport and cleavage modules.
Xiaoxuan Lu, Jiaqi Zou, Geng Han, Mengyao Zhao, Ting Luo, Xiangru Feng, Liangliang Zhu, Yijia Chen, Xiaoguo Ji, Jiayang Jin, Liming Zhao   +10 more
wiley   +1 more source

Discovery and Optimization of AMT‐676, a CDH17‐Targeting ADC for the Treatment of Advanced Gastrointestinal Cancers

Advanced Science, EarlyView.
AMT‐676 is a novel antibody‐drug conjugate targeting CDH17, an adhesion molecule uniquely exposed on gastrointestinal tumor surfaces. Engineered with an optimized exatecan payload, it demonstrates profound tumor regression and a robust bystander effect across diverse preclinical models.
Ying‐nan Wang, Dan‐yun Ruan, Jing Shi, Yue Huang, Hui Sheng, Ya‐ling Huang, Linjie Ma, Lijun Wang, Caiwei Chen, Yixuan Wang, Yue Zhang, Yi Shen, Qing Zhang, Jianjian Zhang, Yanfang Tang, Jin‐ling Zhang, Jia‐jia Hu, Chen‐yi Wu, Jia‐ying Chen, Xun Meng, Shu‐Hui Liu, Feng Wang   +21 more
wiley   +1 more source

The Significance of Good Corporate Governance Principles in The Company Law of 2007

Mimbar, 2017
The purpose of this research was to identified the principles of Good Corporate Governance (GCG) which have not been significantly regulated in the Act Number 40 of 2007 on Limited Company. The research characteristic was qualitative descriptive.
Irwan Sugiarto
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Minutes: Faculty Consultative Committee: December 4, 2008

, 2008
In these minutes: (1) athletic committees; (2) legislative matters; (3) nomination for Faculty Athletics Representative; (4) committee businessUniversity of Minnesota: Faculty Consultative Committee. (2008).
University of Minnesota: Faculty Consultative Committee
core  

Committee meeting before Senate Judiciary Committee [on] nomination of Robert N. Guido, to be a member of the Board of Public Utilities, to succeed himself, for the term prescribed by law

, 1987
Transcript of the committee meeting before Senate Judiciary Committee on the nomination of Robert N. Guido, to be a member of the Board of Public Utilities, to succeed himself, for the term prescribed by law: December 14, 1987, Room 424, State House ...

core   +1 more source