Results 71 to 80 of about 1,135,563 (256)

Sex‐ and Time‐Resolved Physiological and Gut Ecosystem Responses to a Food‐Grade Microbiome‐Targeted Intervention in Collegiate Endurance Athletes

Advanced Science, EarlyView.
In collegiate endurance athletes, a 6‐week randomized CPYE intervention yielded time‐ and sex‐dependent shifts in field‐based cardiorespiratory, metabolic, and redox indices, accompanied by changes in gut multi‐omics profiles. An exploratory extension during intensified training generates hypotheses warranting future validation.
Meng Zhang, Le Ge, Kaiyang Liu, Yanrong Liu, Guolin Zhao, Lai‐Yu Kwok, Zheng Sun, Zhihong Sun, Wenyi Zhang   +8 more
wiley   +1 more source

Nomination of the Regional Director [PDF]

, 2023
The Regional Committee is scheduled to consider the proposals for the post of Regional Director at its seventy-sixth session. The nomination of the Regional Director during the Regional Committee is articulated around two stages: apresentation by each ...
World Health Organization. Regional Office for South-East Asia
core   +1 more source

Public hearing before Senate Judiciary Committee - The nomination interview of Christopher J. Daggett to be commissioner of the New Jersey Department of Environmental Protection

, 1989
Transcript of hearing before the NJ Senate Judiciary Committee on the nomination of Christopher J. Daggett for the role of Commissioner of the New Jersey Department of Environmental Protection.

core   +1 more source

FTSJ3‐Mediated 2′‐O‐Methylation of HSPA5 mRNA Stabilizes BOP1 via SUMOylation to Drive DRP1‐Dependent Mitochondrial Fission and Fatty Acid Oxidation in Lung Squamous Cell Carcinoma

Advanced Science, EarlyView.
The RNA methyltransferase FTSJ3 drives lung squamous cell carcinoma progression by catalyzing 2′‐O‐methylation of HSPA5 mRNA, which stabilizes BOP1 through SUMOylation and activates DRP1/SREBP1‐mediated mitochondrial fission and fatty acid oxidation. Targeting this axis with liposomal siRNA potently suppresses tumor growth and metastasis ABSTRACT Lung ...
Qin Hu, Jiaheng Lin, Yifei Zhu, Ying Liu, Guoren Zhou   +4 more
wiley   +1 more source

Upadacitinib Restrains the Pathogenic Fitness of CD4+ T Cells and Aberrant B Cell Programming in Optic Neuritis

Advanced Science, EarlyView.
Single‐cell profiling and functional perturbation reveal coordinated JAK1‐pSTAT3 downstream programs in optic neuritis, including MCL1‐dependent fitness of pathogenic CD4+ Tem cells and glycolysis‐linked, cholesterol‐sensitive B‐cell responses associated with RORA. Upadacitinib disrupts this reciprocal T‐B‐cell circuit and alleviates neuroinflammation,
Gengchen Jiang, Qi Jiang, Lian Han, Yue Peng, Xingyu Liu, Tong Yang, Hao Huang, Jiaying Liu, Yuan Gao, Hui Yang, Wenjun Zou, Zhaohuai Li, Wenru Su   +12 more
wiley   +1 more source

Selection and appointment of higher education leaders in Ethiopia: An assessment of implementation

Bahir Dar Journal of Education, 2023
The Ethiopian Higher Education Proclamation (No. 650/2009) states that public higher education institutions have the autonomy to nominate top-level leaders.
Abebaw Yirga Adamu
doaj   +2 more sources

The legacy of Erich Mendelsohn – expression and context in the architecture of Modern Movement.

Ochrona Dziedzictwa Kulturowego
In 2021, the international community of architectural and art historians started the so called “Erich Mendelsohn Initiative”, with the goal of inscribing the architectural legacy of Erich Mendelsohn on the UNESCO World Heritage List.
Maria Jolanta Sołtysik
doaj   +1 more source

Board Sub-Committee Effectiveness, Director Attraction and Director Attrition: Do nomination and remuneration committees’ matter?

This study examines whether the effectiveness of board subcommittees is associated with director attrition and the attraction of new directors to boards.
Man Dang, Dessalegn Mihret, Sutharson Kanapathippillai, Premkanth Puwanenthiren   +3 more
core   +1 more source

North Dakota Citizen?s Clean Court Committee Records, 1921-1922 [PDF]

, 2015
The North Dakota Citizens Clean Court Committee Records consist of subject files dealing with the work of the committee in opposing the nomination of Andrew Miller as federal judge.
North Dakota Citizen?s Clean Court Committee
core  

DDX21 Enhances Radiosensitivity in Head and Neck Squamous Cell Carcinoma by Suppressing MK2‐Mediated DNA Damage Response

Advanced Science, EarlyView.
DDX21 suppresses MK2 activation by directly inhibiting Thr334 phosphorylation in a p38‐independent manner, thereby impairing DNA damage response. Clinically, patients with well‐differentiated tumors exhibiting high DDX21 expression are more likely to benefit from adjuvant radiotherapy, whereas those with low DDX21 levels are predisposed to ...
Tianru Yang, Ting Shen, Yanfang Qiu, Wei Zhang, Ziran Zheng, Jiayi Sun, Yuedi Yao, Mianfeng Yao, Jiang Li   +8 more
wiley   +1 more source