Results 131 to 140 of about 116,458 (273)

Metabolic‐immune interactions in gastric cancer T cells: A single‐cell atlas for prognostic biomarker identification

Quantitative Biology, Volume 14, Issue 2, June 2026.
Abstract Metabolic alterations and immune dysfunction within the gastric tumor microenvironment critically drive gastric cancer (GC) progression and therapeutic resistance. Although single‐cell RNA sequencing (scRNA‐seq) has unveiled cellular heterogeneity in GC, the metabolic landscapes of tumor cells and their interplay with immune components remain ...
Junjun Liu, Rui Zhao, Guodong Yao, Zhao Liu, Runze Shi, Jingshu Geng, Guanying Liang, Kexin Chen   +7 more
wiley   +1 more source

Prognostic factors and long‐term outcomes with endoscopic submucosal dissection for colorectal tumors in patients aged 75 years or older

DEN Open, Volume 6, Issue 1, April 2026.
Abstract Background Studies regarding the long‐term outcomes of endoscopic submucosal dissection (ESD) performed in older patients with colorectal tumors are limited. Therefore, in this study, we aimed to analyze the long‐term outcomes of older patients with colorectal tumors who underwent ESD and identify prognostic factors.
Takaya Miura, Satohiro Matsumoto, Azumi Sato, Shu Kojima, Goya Sasaki, Mina Morino, Keita Matsumoto, Hitomi Kashima, Yudai Koito, Takehiro Ishii, Shuhei Yoshikawa, Haruka Otake, Takeshi Uehara, Masanari Sekine, Takeharu Asano, Hiroyuki Miyatani, Hirosato Mashima   +16 more
wiley   +1 more source

Clinical Value of Pelvic Floor Ultrasound and Glazer Pelvic Floor Electromyography in Predicting Postpartum Stress Urinary Incontinence

Journal of Ultrasound in Medicine, Volume 45, Issue 4, Page 795-803, April 2026.
Objectives Based on pelvic floor ultrasound and Glazer pelvic floor surface electromyography parameters in postpartum patients with stress urinary incontinence (SUI), this study aims to establish a model and explore its clinical value in predicting the disease.
Lingyu Yang, Yan Wang, Fen Gu, Yi Ren, Jing Ning   +4 more
wiley   +1 more source

FNDC1 Competitively Binds Gβ2 to Suppress the β‐Catenin–Destruction Complex and Promote Gastric Cancer Malignancy

The FASEB Journal, Volume 40, Issue 6, 31 March 2026.
FNDC1 competitively binds Gβ2 to suppress the β‐catenin–destruction complex and promote the malignant behavior of gastric cancer (GC) by the following mechanism: elevated FNDC1 competes with Dvl for binding to Gβ2, thereby reducing Dvl–Gβ2 interaction; this reduction inhibits Dvl degradation in the cytoplasm; increased Dvl recruits Axin1, thereby ...
Wenyu Gao, Hao Chen, Fangyu Lin, Jialin Liu, Tingxuan Huang, Han Wang, Xiaojiao Weng, Xinli Wang, Xiaoyan Lin, Tao Jiang   +9 more
wiley   +1 more source

Predicting Risk of Lymph Node Metastasis in Neuroendocrine Carcinoma of Cervix: A Validated Nomogram Incorporating Neuroendocrine Markers and Clinical Parameters [PDF]

Cancer Med
This study creates a nomogram model to predict risk probability of lymph node metastasis in NECC based on neuroendocrine biomarkers (CD56) and clinical factors. This model is superior to other existing models through the comparison. And it enables clinicians to identify low‐risk patients (risk probability threshold: 0.20) to guide the individualized ...
Jia M, Zeng S, Zou J, Chen H, Lin C, Yang S, Pi J, Xiao X.   +7 more
europepmc   +2 more sources

Cancer‐associated fibroblasts are associated with CD8+ T cell depletion and poor prognosis in colorectal adenocarcinoma: a multi‐omics and machine learning analysis

The Journal of Pathology: Clinical Research, Volume 12, Issue 2, March 2026.
Abstract Fibroblastic proliferation in various tumor microenvironments influences cancer survival through complex interactions with diverse immune responses. This study investigated the impact of histologically unique activated cancer‐associated fibroblasts (aCAFs) on survival outcomes and immune responses and examined their association with various ...
Myungsun Shim, One‐Zoong Kim, Byoung Kwan Son, Jung Ki Jo, Seung Wook Lee, Hong Sang Moon, Hyung Suk Kim, Mi Jung Kwon, Sung Hak Lee, Yung‐Kyun Noh, Kyueng‐Whan Min   +10 more
wiley   +1 more source

Preoperative predictors of adverse pathology and recurrence‐free survival for patients with renal masses

BJUI Compass, Volume 7, Issue 3, March 2026.
Abstract Objectives Our objective was to develop algorithms to predict adverse pathology (AP) and recurrence‐free survival (RFS) for patients with renal tumours primarily based on multifaceted analysis of preoperative CT imaging. Patients/Methods Seven hundred forty‐eight patients with non‐metastatic renal tumours managed with definitive surgery at ...
Akira Kazama, Carlos Munoz‐Lopez, Worapat Attawettayanon, Eran Maina, Nityam Rathi, Kieran Lewis, Anne Wong, Angelica Bartholomew, Rebecca A. Campbell, Jihad Kaouk, Samuel Haywood, Nima Almassi, Christopher J. Weight, Nick Heller, Shetal Shah, Erick M. Remer, Ryan Ward, Amy S. Nowacki, Steven C. Campbell   +18 more
wiley   +1 more source

Identifying recurrent stone formers with machine learning: A single‐centre observational study

BJUI Compass, Volume 7, Issue 3, March 2026.
Abstract Objectives Kidney stones affect 12% of the population over their lifetime. Recurrent kidney stones lead to repeated interventions and excessive healthcare costs. Despite progress in imaging and metabolic evaluations, models to accurately identify patients at high risk are missing.
Pedro Amado, Daniel G. Fuster, Matteo Bargagli, Dominik Obrist, Fiona Burkhard, Beat Roth, Francesco Clavica, Shaokai Zheng   +7 more
wiley   +1 more source

The learning curve of single‐port extraperitoneal robotic radical prostatectomy: Initial experience and outcomes from a newly graduated fellowship‐trained robotic surgeon

BJUI Compass, Volume 7, Issue 3, March 2026.
Abstract Introduction and Objective This study aims to evaluate the learning curve and perioperative outcomes of single‐port extraperitoneal robotic radical prostatectomy (SP‐EP‐RARP) performed by a single surgeon at a high‐volume academic institution. Methods A retrospective review of a prospectively maintained database was conducted for patients who ...
Jacob S. Hershenhouse, Simon Kim, Rafael Gevorkyan, Brian Hom, Michael Eppler, Patrick Ford, Ram Pathak, Riccardo Autorino, Andre Abreu, Ketan K. Badani, Simone Crivellaro, Sij Hemal   +11 more
wiley   +1 more source

Prognosis Prediction and Surgical Benefit Subgroup Analysis in Anal Squamous Cell Carcinoma Patients Undergoing Concurrent Chemoradiotherapy

Cancer Medicine
Background This study aimed to develop a nomogram to predict overall survival in anal squamous cell carcinoma (ASCC) patients undergoing chemoradiotherapy and to identify patients who may benefit from surgery.
Quan Wang, Guangmin Wan, Lu Yang, Gang Xu   +3 more
doaj   +1 more source