Results 71 to 80 of about 98,059 (236)

A Systematic Comparison of Alpha‐Synuclein Seed Amplification Assays for Increasing Reproducibility

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Seed amplification assays (SAAs) enable ultrasensitive detection of misfolded α‐synuclein across biofluids and tissues. Yet, heterogeneity in protocols limits cross‐study comparability and clinical translation. Here, we review α‐synuclein SAA methods and their performance across various biological matrices.
Manuela Amaral‐do‐Nascimento, Daniela F. Santos, Tuane C. R. G. Vieira, Tiago F. Outeiro   +3 more
wiley   +1 more source

Investigation on Designing and Development of a Selective Laser Melting Manufactured Gas Turbine Blade—Proof-of-Concept

Inventions
In this study, a conceptual turbine blade model with internal cooling channels was designed and fabricated using the selective laser melting (SLM) process. The optimal manufacturing orientation was evaluated through simulations, and the results indicated
Mihaela Raluca Condruz, Tiberius Florian Frigioescu, Gheorghe Matache, Adina Cristina Toma, Teodor Adrian Badea   +4 more
doaj   +1 more source

Constant approximation algorithms for embedding graph metrics into trees and outerplanar graphs

, 2010
In this paper, we present a simple factor 6 algorithm for approximating the optimal multiplicative distortion of embedding a graph metric into a tree metric (thus improving and simplifying the factor 100 and 27 algorithms of B\v{a}doiu, Indyk, and ...
Chepoi, Victor, Dragan, Feodor, Newman, Ilan, Rabinovich, Yuri, Vaxes, Yann   +4 more
core   +3 more sources

Early Clinical, Imaging, and Pathological Characteristics of SRPK3/TTN‐Digenic Myopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SRPK3/TTN‐digenic myopathy was recently established as a skeletal muscle myopathy caused by digenic inheritance. This study characterizes the early clinical presentation of SRPK3/TTN‐digenic myopathy in one previously reported and seven newly identified pediatric patients.
Rotem Orbach, Sandra Donkervoort, Carola Hedberg‐Oldfors, Giovanni Baranello, Dimah Saade, Precilla D'Souza, Ruchee Patel, Eva Michael, A. Reghan Foley, Diana Bharucha‐Goebel, S. Jin Haugland, Meghan McAnally, Omer Abdul Hamid, Katherine Chao, Ellen F. Macnamara, Alan H. Beggs, Anna Sarkozy, Juliane Mueller, Steven A. Moore, Richard S. Finkel, Cynthia J. Tifft, Francesco Muntoni, Anders Oldfors, Carsten G. Bönnemann   +23 more
wiley   +1 more source

Additive manufacturing-by-design for support structures: a critical review

International Journal of Extreme Manufacturing
Support structure, a critical component in the design for additive manufacturing (DfAM), has been largely overlooked by additive manufacturing (AM) communities.
Jinlong Su, Yang Mo, Peijie Shangguan, Chinnapat Panwisawas, Fulin Jiang, Swee Leong Sing   +5 more
doaj   +1 more source

Near Optimal Online Distortion Minimization for Energy Harvesting Nodes

, 2017
We consider online scheduling for an energy harvesting communication system where a sensor node collects samples from a Gaussian source and sends them to a destination node over a Gaussian channel.
Arafa, Ahmed, Ulukus, Sennur
core   +1 more source

Clinical Impact of NOTCH3 Variant Location After First Stroke in CADASIL

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Despite its monogenic origin, Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy exhibits marked variability in clinical expression and severity. Variants in the NOTCH3 gene, within epidermal growth factor‐like repeat domains 1–6 or 7–34, are known to influence disease onset, but their impact ...
Léa Aguilhon, Hugues Chabriat, Dominique Hervé, Stéphanie Guey, Sophie Tezenas Du Montcel, Juliette Ortholand   +5 more
wiley   +1 more source

Sarilumab in Polyarticular‐Course Juvenile Idiopathic Arthritis: Dose‐Finding and 1‐Year Analysis of a Phase 2b, Open‐Label, Multicenter Study

Arthritis Care &Research, EarlyView.
Objective This study assessed sarilumab in treating patients with polyarticular‐course juvenile idiopathic arthritis (pcJIA). Methods This phase 2b, open‐label study (NCT02776735) consisted of three sequential parts (each with a core‐treatment and extension phase).
Fabrizio De Benedetti, Inmaculada C. Penadés, Irina Nikishina, Ivan Foeldvari, Alberto J. Spindler, Anna Kozlova, Nadina Rubio‐Pérez, Pierre Quartier, Zbigniew Żuber, Raul Barria, Daniel Clemente, Gabriel V. Cornejo, Katherine Marzan, Nancy Liu, Christine Xu, Stephen DiMartino, Angeliki Giannelou, Fei Cao‐Ghoul, Bolanle Akinlade, Lydie Baret‐Cormel   +19 more
wiley   +1 more source

Reduced-Dimension Linear Transform Coding of Correlated Signals in Networks

, 2012
A model, called the linear transform network (LTN), is proposed to analyze the compression and estimation of correlated signals transmitted over directed acyclic graphs (DAGs). An LTN is a DAG network with multiple source and receiver nodes. Source nodes
Gastpar, Michael, Goela, Naveen
core   +1 more source

Analysis of Noise Propagation Mechanisms in Wireless Optical Coherent Communication Systems

Applied Sciences
This paper systematically analyzes the propagation, transformation, and accumulation mechanisms of multi-source noise and device non-idealities within the complete signal chain from the transmitter through the channel to the receiver, focusing on ...
Fan Ji, Xizheng Ke
doaj   +1 more source