Results 181 to 190 of about 13,463,233 (298)

Nonlinear modeling of health checkup factors and future claims-based healthcare costs in Japan: a retrospective cohort study. [PDF]

Health Econ Rev
Nakamura H, Harada K, Hirako K, Sawamura T, Imamura K, Sagae M, Nambo H, Karashima S.   +7 more
europepmc   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Computing Additive Chained Volume Measures of GDP Subaggregates

This paper derives formulas for additive chained volume measures (CVMs) of GDP subaggregates depending on the underlying GDP quantity index. In turn, this paper explains why the formulas used in current practice yield non-additive CVMs.
Jesus C. Dumagan
core  

Is there evidence for additive neurocognitive deficits in adults with attention-deficit/hyperactivity disorder and co-occurring conditions? [PDF]

Arch Clin Neuropsychol
Harrison AG, Davin N, Kwan D.
europepmc   +1 more source

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

Refining methodological approaches for analysing higher-throughput locomotor behaviour, using generalized additive mixed models. [PDF]

Front Toxicol
Wasser-Bennett G, Dimitriadou S, Winter MJ, Brown AR, Hillman C, Miller M, Tyler CR.   +6 more
europepmc   +1 more source

Comparing the paths of Hedgehog release in artificial and natural settings

FEBS Letters, EarlyView.
Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley   +1 more source

Exploring Redox-Inflammation Interactions: Tanshinones from <i>Salvia miltiorrhiza</i> as Potential Modulators of Intestinal Health in Livestock. [PDF]

Antioxidants (Basel)
Soliman M, Du C, Liu X, Zhao L, Cheng L.
europepmc   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Balancing gain and diversity: Optimal contribution selection for sustainable genetic improvement in sugarcane. [PDF]

Plant Genome
Vo Van-Zivkovic N, Hayes BJ, Aitken K, Dinglasan E, Morgan T, Yadav S.   +5 more
europepmc   +1 more source